ACS Applied Bio Materials,
Год журнала:
2023,
Номер
7(1), С. 44 - 58
Опубликована: Дек. 18, 2023
Epithelial-mesenchymal
transition
(EMT)
is
a
fundamental
process
driving
cancer
metastasis,
transforming
non-motile
cells
into
motile
population
that
migrates
to
distant
organs
and
forms
secondary
tumors.
In
recent
years,
research
has
revealed
strong
connection
between
exosomes
the
EMT.
Exosomes,
subpopulation
of
extracellular
vesicles,
facilitate
cellular
communication
dynamically
regulate
various
aspects
including
immune
cell
suppression,
matrix
remodeling,
metastasis
initiation,
EMT
organ-specific
metastasis.
Tumor-derived
(TEXs)
their
molecular
cargo,
comprising
proteins,
lipids,
nucleic
acids,
carbohydrates,
are
essential
components
promote
in
cancer.
TEXs
miRNAs
play
crucial
role
reprogramming
tumor
microenvironment,
while
TEX
surface
integrins
contribute
Exosome-based
offers
deeper
understanding
about
an
effective
theranostic
platform
development.
Additionally,
therapeutic
sources
paving
way
for
innovative
treatment
this
Review,
we
spotlight
impact,
aiming
inspire
researchers
worldwide
explore
fascinating
field
more
ways.
Clinical and Translational Discovery,
Год журнала:
2023,
Номер
3(3)
Опубликована: Май 26, 2023
Abstract
Extracellular
vesicles
(EVs)
are
an
innovative
orientation
of
next‐generation
cancer
medicine.
In
EVs,
the
exosome
is
most
exciting
domain
associated
with
research
current
decade.Exosomes
have
both
progression
related
and
healing
capabilities
depending
on
source.
It
develops
a
new
platform
for
personalized
precision
medicine
visionary
project
to
come
reality.
The Journal of Liquid Biopsy,
Год журнала:
2024,
Номер
3, С. 100138 - 100138
Опубликована: Янв. 4, 2024
Extracellular
vesicles
(EVs)
are
the
cell's
secreted
component.
It
is
majorly
classified
into
microvesicles,
apoptotic
bodies,
and
exosomes.
Exosomes
play
a
significant
role
in
cancer
development
progression.
Its
molecular
signature
(DNA,
RNA,
Proteins,
lipids)
has
more
priority
profiling
current
decade.
In
prevention,
most
challenging
part
early
detection.
EVs-based
screening
develops
promising
platform.
Multi-Omics
exosomes
profiling-based
liquid
biopsy
support
detection
efficient
way.
This
approach
provides
detailed
expression
data
(it
may
be
inner
cargos
or
surface
express
molecules).
article
highlited
multi-omic
exosome
theranostics
applications
cancer,
technical
challenges,
improvisation
for
future
improvement.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(8), С. 8489 - 8506
Опубликована: Апрель 15, 2024
Cancer
is
the
most
challenging
health
complication
worldwide.
Scientific
society
has
tried
to
decode
its
complications
and
developing
a
smart
solution
for
mankind.
Extracellular
vesicles
(EVs)
are
an
emerging
frontier
in
cancer
research.
EVs
provide
fresh
insight
into
understanding
of
released
from
all
active
cells.
classified
some
major
classes,
such
as
apoptotic
bodies,
microvesicles,
exosomes.
Exosomes
among
exciting
tools
current
research
they
work
cellular
messengers
(which
reflects
cell's
healthy
or
pathological
conditional
status).
In
tumor
microenvironment,
regulate
several
complicated
events
uncontrolled
cell
growth,
immune
suppression,
angiogenesis,
extracellular
matrix
remodeling,
metastasis,
organ-specific
drug
therapeutic
resistance,
stem
development.
also
source
promising
biomarkers
involved
both
diagnosis
prognosis
performs
role.
Exosomes-based
nanomedicine
which
application
nanosize
theranostics
sensor
orientation,
supports
overcoming
management
limitations,
early
therapeutics
specific,
effective,
affordable.
this
review,
we
have
highlighted
integration
exosomes
nanotechnology
cutting-edge
approach
precision
oncology.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3657 - 3675
Опубликована: Апрель 1, 2024
Abstract:
Exosomes
are
extracellular
vesicles
that
originate
from
various
cells
and
mediate
intercellular
communication,
altering
the
behavior
or
fate
of
recipient
cells.
They
carry
diverse
macromolecules,
such
as
lipids,
proteins,
carbohydrates,
nucleic
acids.
Environmental
stressors
can
change
exosomal
contents
many
cells,
making
them
useful
for
diagnosing
chronic
disorders,
especially
neurodegenerative,
cardiovascular,
cancerous,
diabetic
diseases.
Moreover,
exosomes
be
engineered
therapeutic
agents
to
modulate
disease
processes.
State-of-art
techniques
employed
separate
including
ultracentrifugation,
size-exclusion
chromatography
immunoaffinity.
However,
modern
technologies
aqueous
two-phase
system
well
microfluidics
gaining
attention
in
recent
years.
The
article
highlighted
composition,
biogenesis,
implications
exosomes,
standard
novel
methods
isolating
applying
biomarkers
cargo
carriers.
Keywords:
Exosomes,
vesicles,
biomarkers,
carriers,
separation
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(4), С. 2128 - 2139
Опубликована: Апрель 3, 2024
Cancer
research
has
made
significant
progress
in
recent
years,
and
extracellular
vesicles
(EVs)
based
cancer
investigation
reveals
several
facts
about
cancer.
Exosomes
are
a
subpopulation
of
EVs.
In
the
present
decade,
exosomes
is
mostly
highlighted
for
theranostic
research.
Tumor
cell
derived
(TEXs)
promote
but
there
multiple
sources
that
can
be
used
as
therapeutic
agents
(plant
exosomes,
stem
cell-derived
modified
or
synthetic
exosomes).
Stem
cells
regenerative
medicine
faces
numerous
challenges,
such
tumor
development,
cellular
reprogramming
etc.,
therefore
addressing
these
complications
becomes
essential.
serves
an
answer
to
problems
offers
better
solution.
Global
indicates
also
play
dual
role
system
by
either
inhibiting
promoting
Modified
which
genetically
engineered
surface
increase
efficacy
properties
considered
target
above
concerns.
However,
difficulties
associated
with
include
variations
heterogenity,
isolation
protocols,
large
scale
production,
have
managed
effectively.
this
review,
we
explore
biogenesis,
exosome
sources,
drug
delivery,
clinical
trial
related
challenges
domain
future
orientation.
This
article
may
encourage
researchers
develop
effective
affordable
Biology,
Год журнала:
2025,
Номер
14(1), С. 27 - 27
Опубликована: Янв. 1, 2025
Exosomes
are
small
extracellular
vesicles
and
crucial
in
intercellular
communication.
Interestingly,
tumor-derived
exosomes
carry
oncogenic
molecules,
such
as
proteins
microRNAs,
which
can
reprogram
recipient
cells,
promote
angiogenesis,
stimulate
cancer
pre-metastatic
niche,
supporting
growth
metastasis.
On
the
other
hand,
their
biocompatibility,
stability,
ability
to
cross
biological
barriers
make
them
attractive
candidates
for
drug
delivery.
Recent
advances
have
shown
potential
be
used
early
disease
detection
targeted
therapy
by
delivering
therapeutic
agents
specifically
tumor
sites.
Despite
promising
applications,
a
number
of
challenges
remain,
including
exosome
isolation
characterization,
well
inherent
heterogeneity.
Thus,
current
review
aims
describe
roles
health
disease,
discuss
that
hinder
development
into
becoming
useful
medical
tools.
