Advanced Materials,
Год журнала:
2023,
Номер
36(13)
Опубликована: Ноя. 6, 2023
Abstract
Messenger
RNA
(mRNA)‐based
therapy
has
emerged
as
a
powerful,
safe,
and
rapidly
scalable
therapeutic
approach
that
involves
technologies
for
both
mRNA
itself
the
delivery
vehicle.
Although
there
are
some
unique
challenges
different
applications
of
therapy,
common
challenge
all
therapeutics
is
transport
into
target
cell
cytoplasm
sufficient
protein
expression.
This
review
focused
on
behaviors
at
cellular
level
nanotechnology‐mediated
systems,
which
have
not
been
comprehensively
reviewed
yet.
First,
four
main
introduced,
including
immunotherapy,
replacement
genome
editing,
reprogramming.
Second,
types
cargos
systems
summarized.
Third,
strategies
to
enhance
efficiency
during
trafficking
process
highlighted,
accumulation
cell,
internalization
endosomal
escape,
release
from
nanocarrier,
translation
protein.
Finally,
opportunities
development
presented.
can
provide
new
insights
future
fabrication
nanocarriers
with
desirable
performance.
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 25, 2023
Abstract
Renal
cell
carcinoma
(RCC)
is
a
common
urological
malignancy
and
represents
leading
threat
to
healthcare.
Recent
years
have
seen
series
of
progresses
in
the
early
diagnosis
management
RCC.
Theranostic
lipid
nanoparticles
(LNPs)
are
increasingly
becoming
one
focuses
this
field,
because
their
suitability
for
tumor
targeting
multimodal
therapy.
LNPs
can
be
precisely
fabricated
with
desirable
chemical
compositions
biomedical
properties,
which
closely
match
physiological
characteristics
clinical
needs
Herein,
comprehensive
review
theranostic
presented,
emphasizing
generic
tool
nature
developing
advanced
micro‐nano
biomaterials.
It
begins
brief
overview
formation
mechanism
LNPs,
followed
an
introduction
kidney‐targeting
approaches,
such
as
passive,
active,
stimulus
responsive
targeting.
With
examples
provided,
modification
strategies
enhancing
functionality
discussed.
Thereafter,
research
advances
on
applications
these
RCC
including
bioimaging,
liquid
biopsy,
drug
delivery,
physical
therapy,
gene
therapy
summarized
discussed
from
interdisciplinary
perspective.
The
final
part
highlights
milestone
achievements
translation
medicine,
current
challenges
well
future
development
directions
treatment
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Despite
their
potential,
the
adoption
of
nanotechnology
in
therapeutics
remains
limited,
with
only
around
eighty
nanomedicines
approved
past
30
years.
This
disparity
is
partly
due
to
"one-size-fits-all"
approach
medical
design,
which
often
overlooks
patient-specific
variables
such
as
biological
sex,
genetic
ancestry,
disease
state,
environment,
and
age
that
influence
nanoparticle
behavior.
Nanoparticles
(NPs)
must
be
transported
through
systemic,
microenvironmental,
cellular
barriers
vary
across
heterogeneous
patient
populations.
Key
patient-dependent
properties
impacting
NP
delivery
include
blood
flow
rates,
body
fat
distribution,
reproductive
organ
vascularization,
hormone
protein
levels,
immune
responses,
chromosomal
differences.
Understanding
these
crucial
for
developing
effective,
nanotechnologies.
The
formation
a
corona
NPs
upon
exposure
fluids
significantly
alters
properties,
affecting
biodistribution,
pharmacokinetics,
cytotoxicity,
targeting.
dynamics
corona,
time-dependent
composition
soft
hard
coronas,
depend
on
characteristics
serum
components.
review
highlights
importance
understanding
different
backgrounds
its
implications
including
age,
state.
By
exploring
variables,
we
aim
advance
development
personalized
nanomedicine,
improving
therapeutic
efficacy
outcomes.
