Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(4)
Опубликована: Март 31, 2025
ABSTRACT
3D
printing
technology
has
shown
significant
promise
in
bone
tissue
engineering,
enabling
the
fabrication
of
intricate
structures
while
controlling
porosity
and
mechanical
properties.
Integrating
into
provides
a
vital
benefit
by
allowing
implants
to
precisely
match
an
individual's
anatomy,
improving
outcomes
reducing
risk
rejection.
Additionally,
this
approach
supports
inclusion
bioactive
substances
growth
factors
enhance
regeneration.
This
study
examines
most
recent
advances
for
production,
stressing
their
potential
regenerative
medicine
personalized
healthcare.
It
also
addresses
challenges
associated
with
current
processes
engineering
explores
possible
avenues
future
research
development.
Furthermore,
article
investigates
how
biocompatibility
bioactivity
materials
used
facilitate
effective
Likewise,
it
evaluates
scaffold
design
architecture
can
promote
cell
attachment,
proliferation,
differentiation,
thereby
encouraging
successful
restoration.
In
conclusion,
thorough
assessment
offers
critical
insights
progress
obstacles
proposes
directions
inquiry
exciting
field.
By
leveraging
these
advancements,
clinicians
researchers
pioneer
new
therapies
that
address
defects
improve
outcomes.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 21, 2024
Abstract
Persistent
oxidative
stress
and
bacterial
infection
are
significant
challenges
that
impede
diabetic
wound
healing.
By
combining
diagnosis
treatment,
pH
variation
on
the
tissue
can
be
monitored
in
real
time,
precise
treatment
carried
out
promptly
to
promote
In
this
study,
a
lipoic
acid‐modified
chitosa
(LAMC)
hydrogel
is
constructed
via
an
amidation
reaction,
ceria
oxide‐molybdenum
disulfide
nanoparticles
with
polydopamine
layer
(C@M@P),
along
carbon
quantum
dots
(CDs)
synthesized
by
hydrothermal
method,
loaded
into
hydrogel,
thus
developing
diagnostic
therapeutic
(LAMC/CD‐C@M@P).
incorporating
CDs,
exhibits
high
sensitivity
reversibility
under
ultraviolet
light.
Furthermore,
images
of
hydrogels
collected
using
smartphones
converted
signals,
providing
means
for
early
detection
infection.
Notably,
LAMC/CD‐C@M@P
excellent
photothermal
antibacterial
capability
against
Staphylococcus
aureus
Escherichia
coli
remarkable
antioxidant
anti‐inflammatory
abilities
alleviate
reactive
oxygen
species
relieve
inflammation
response.
summary,
multifunctional
offers
great
potential
as
innovative
dressing
platform,
representing
advancement
chronic
management.
The
development
of
bioactive
scaffolds
by
mimicking
bone
tissue
extracellular
matrix
is
promising
for
regeneration.
Herein,
inspired
the
composition,
a
novel
pearl
powder
(PP)
hybrid
fish
gelatin
methacrylate
(GelMa)
hydrogel
scaffold
loaded
with
vascular
endothelial
growth
factor
(VEGF)
regeneration
presented.
With
help
microfluidic-assisted
3D
printing
technology,
composition
and
structure
can
be
accurately
controlled
to
meet
clinical
requirements.
combination
skin
GelMa
PP
also
endowed
good
biocompatibility,
cell
adhesion,
osteogenic
differentiation
ability.
Moreover,
release
VEGF
enables
promote
angiogenesis.
Thus,
in
proposed
could
accelerated
under
synergic
effect
osteogenesis
angiogenesis,
which
has
been
proved
rat
skull
defect
model.
These
features
indicate
that
will
an
ideal
candidate
applications.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 3, 2024
Abstract
The
reaction
system
of
hydrogen
peroxide
(H
2
O
)
catalyzed
by
nanozyme
has
a
broad
prospect
in
antibacterial
treatment.
However,
the
complex
catalytic
activities
nanozymes
lead
to
multiple
pathways
reacting
parallel,
causing
uncertain
results.
New
approach
effectively
regulate
is
urgent
need.
Herein,
Cu
single
site
modified
on
nanoceria
with
various
activities,
such
as
peroxidase-like
activity
(POD)
and
hydroxyl
radical
antioxidant
capacity
(HORAC).
Benefiting
from
interaction
between
coordinated
CeO
substrate,
POD
enhanced
while
HORAC
inhibited,
which
further
confirmed
density
functional
theory
(DFT)
calculations.
Cu-CeO
+
H
shows
good
properties
both
vitro
vivo.
In
this
work,
strategy
based
metal
carrier
provides
general
clue
for
optimizing
nanozymes.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(3), С. 1167 - 1315
Опубликована: Янв. 1, 2024
Silicon-based
biomaterials
have
been
extensively
developed
in
the
past
decades.
The
classification,
characteristics,
multi-dimensional
design,
and
biomedical
applications
of
silicon-containing
are
comprehensively
elaborated.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 4, 2025
Osteoporosis
results
from
a
disruption
in
skeletal
homeostasis
caused
by
an
imbalance
between
bone
resorption
and
formation.
Conventional
treatments,
such
as
pharmaceutical
drugs
hormone
replacement
therapy,
often
yield
suboptimal
are
frequently
associated
with
side
effects.
Recently,
biomaterial-based
approaches
have
gained
attention
promising
alternatives
for
managing
osteoporosis.
This
review
summarizes
the
current
advancements
3D-printed
biomaterials
designed
osteoporosis
treatment.
The
benefits
of
compared
to
traditional
systemic
drug
therapies
discussed.
These
materials
can
be
broadly
categorized
based
on
their
functionalities,
including
promoting
osteogenesis,
reducing
inflammation,
exhibiting
antioxidant
properties,
inhibiting
osteoclast
activity.
3D
printing
has
advantages
speed,
precision,
personalization,
etc.
It
is
able
satisfy
requirements
irregular
geometry,
differentiated
composition,
multilayered
structure
articular
osteochondral
scaffolds
boundary
layer
structure.
limitations
existing
critically
analyzed
future
directions
considered.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 1, 2024
Abstract
Infective
bone
defect
is
increasingly
threatening
human
health.
How
to
achieve
the
optimal
antibacterial
activity
and
regenerative
repair
of
infective
simultaneously
a
huge
challenge
in
clinic.
Herein,
this
work
reports
rational
integration
Mn
single‐atom
nanozyme
into
3D‐printed
bioceramic
scaffolds
(Mn/HSAE@BCP
scaffolds).
The
integrated
Mn/HSAE@BCP
can
catalyze
conversion
H
2
O
produce
hydroxyl
radical
(
•
OH)
superoxide
anion
(O
•−
)
through
cascade
reaction.
Besides,
prominent
thermal
efficiency
be
utilized
for
sonodynamic
therapy
(SDT).
synergetic
strategy
chemodynamic
(CDT)/SDT
enables
sufficient
generation
reactive
oxygen
species
(ROS)
kill
Staphylococcus
aureus
S.
or
Escherichia
coli
E.
).
Furthermore,
enhanced
efficacy
beneficial
upregulate
expression
osteogenesis‐related
markers
(such
as
collagen
1(COL1),
Runt‐related
transcription
factor
(Runx2),
osteocalcin
(OCN),
osteoprotegerin
(OPG))
vitro
further
promote
regeneration
vivo.
results
demonstrate
good
potential
regeneration,
which
provide
an
effective
method
treatment
clinical
defect.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 6, 2024
Myocardial
infarction
(MI)
has
a
5-year
mortality
rate
of
more
than
50%
due
to
the
lack
effective
treatments.
Interactions
between
cardiomyocytes
and
MI
microenvironment
(MIM)
can
determine
progression
fate
infarcted
myocardial
tissue.
Here,
specially
designed
Melanin-based
composite
nanomedicines
(MCN)
is
developed
effectively
treat
by
reprogramming
MIM.
MCN
nanocomposite
composed
polydopamine
(P),
Prussian
blue
(PB)
cerium
oxide
(CexOy)
with
Mayuan-like
structure,
which
MIM
efficient
conversion
detrimental
substances
(H+,
reactive
oxygen
species,
hypoxia)
into
beneficial
status
(O2
H2O).
In
coronary
artery
ligation
ischemia
reperfusion
models
male
mice,
intravenously
injecting
specifically
targets
damaged
area,
resulting
in
restoration
cardiac
function.
With
its
promising
therapeutic
effects,
constitutes
new
agent
for
treatment
demonstrates
potential
clinical
application.
most
common
emergent
manifestation
cardiovascular
diseases.
authors
nanomedicine
that
reprogram
converting
ROS
elements
H2O),
as
such
