Biomaterials Science, Год журнала: 2024, Номер 12(7), С. 1662 - 1692
Опубликована: Янв. 1, 2024
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, potential applications for cancer treatment and future development prospects are also prospected.
Язык: Английский
Small, Год журнала: 2024, Номер 20(26)
Опубликована: Янв. 12, 2024
Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application
Язык: Английский
Процитировано
19
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
8
Materials Today Bio, Год журнала: 2025, Номер 30, С. 101443 - 101443
Опубликована: Янв. 5, 2025
Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and poor prognosis. The blood-brain barrier (BBB) blood-tumor (BTB) present significant obstacles to efficacy of tumor-targeted pharmacotherapy, thereby impeding therapeutic potential numerous candidate drugs. Targeting delivery adequate doses drug across BBB treat GBM has become prominent research area in recent years. This emphasis driven exploration evaluation diverse technologies for with some already undergoing clinical trials. review provides thorough overview advancements challenges targeted treatment. It specifically emphasizes systemic administration strategies assess their limitations Furthermore, this highlights promising future directions development intelligent systems aimed at overcoming current enhancing against GBM. These not only support foundational on but also offer methodological approaches applications.
Язык: Английский
Процитировано
4
Biomaterials, Год журнала: 2025, Номер 318, С. 123138 - 123138
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
3
Small, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Glioblastoma (GBM), the most malignant brain tumor with high prevalence, remains highly resistant to existing immunotherapies due significant immunosuppression within microenvironment (TME), predominantly manipulated by M2‐phenotypic tumor‐associated macrophages (M2‐TAMs). Here in this work, an M2‐TAMs targeted nano‐reprogrammers, MG5‐S‐IMDQ, is established decorating mannose molecule as targeting moiety well toll‐like receptor (TLR) 7/8 agonist, imidazoquinoline (IMDQ) on dendrimeric nanoscaffold. MG5‐S‐IMDQ demonstrated excellent capacity of penetrating blood‐brain barrier (BBB) selectively GBM microenvironment, leading a phenotype transformation and function restoration TAMs shown heightened phagocytic activity toward cells, enhanced cytotoxic effects, improved antigen cross‐presentation capability. In meantime, induction function‐oriented “gear effect”, treatment extended its impact systemically enhancing infiltration type I conventional dendritic cells (cDC1s) into sites bolstering adaptive immune responses. sum, precisely working unique target situ, nano‐reprogrammers successfully robust network that worked synergistically combat tumors. This facile nanoplatform‐based immunomodulatory strategy, serving powerful convenient monotherapy or complementary alongside other therapies like surgery, provided deep insights for advancing translational study GBM.
Язык: Английский
Процитировано
2
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101606 - 101606
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2023, Номер 17(9), С. 8646 - 8662
Опубликована: Апрель 26, 2023
Apoptotic vesicles (ApoVs) hold great promise for inflammatory regulation and tissue repair. However, little effort has been dedicated to developing ApoV-based drug delivery platforms, while the insufficient targeting capability of ApoVs also limits their clinical applications. This work presents a platform architecture that integrates apoptosis induction, loading, functionalized proteome regulation, followed by modification, enabling creation an apoptotic vesicle system treat ischemic stroke. Briefly, α-mangostin (α-M) was utilized induce mesenchymal stem cell (MSC) being loaded onto MSC-derived as anti-oxidant anti-inflammatory agent cerebral ischemia/reperfusion injury. Matrix metalloproteinase activatable cell-penetrating peptide (MAP), microenvironment-responsive peptide, modified on surface obtain MAP-functionalized α-M-loaded ApoVs. Such engineered targeted injured brain after systemic injection achieved enhanced neuroprotective activity due synergistic effect α-M. The internal protein payloads ApoVs, upon α-M activation, were found engaged in regulating immunological response, angiogenesis, proliferation, all which contributed therapeutic effects findings provide universal framework creating systems amelioration diseases demonstrate potential neural
Язык: Английский
Процитировано
36
The Innovation, Год журнала: 2023, Номер 5(1), С. 100548 - 100548
Опубликована: Ноя. 27, 2023
•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.
Язык: Английский
Процитировано
35
International Journal of Pharmaceutics, Год журнала: 2023, Номер 636, С. 122759 - 122759
Опубликована: Фев. 20, 2023
The blood-brain barrier (BBB) limits the access of substances to central nervous system (CNS) which hinders treatment pathologies affecting brain and spinal cord. Nowadays, research is focus on new strategies overcome BBB can treat CNS are needed. In this review, different that allow increase analysed extended commented, not only invasive but also non-invasive ones. techniques include direct injection into parenchyma or CSF therapeutic opening BBB, while use alternative routes administration (nose-to-brain route), inhibition efflux transporters (as it important prevent drug from enhance efficiency), chemical modification molecules (prodrugs delivery systems (CDDS)) nanocarriers. future, knowledge about nanocarriers diseases will continue increase, other such as repurposing reprofiling, cheaper less time consuming, may limit its transfer society. main conclusion combination be most interesting approach CNS.
Язык: Английский
Процитировано
34
Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1439 - 1439
Опубликована: Май 8, 2023
Cancer is designated as one of the principal causes mortality universally. Among different types cancer, brain cancer remains most challenging due to its aggressiveness, ineffective permeation ability drugs through blood–brain barrier (BBB), and drug resistance. To overcome aforementioned issues in fighting there an imperative need for designing novel therapeutic approaches. Exosomes have been proposed prospective “Trojan horse” nanocarriers anticancer theranostics owing their biocompatibility, increased stability, permeability, negligible immunogenicity, prolonged circulation time, high loading capacity. This review provides a comprehensive discussion on biological properties, physicochemical characteristics, isolation methods, biogenesis internalization exosomes, while it emphasizes diagnostic potential vehicle systems highlighting recent advances research field. A comparison activity effectiveness several exosome-encapsulated cargo including biomacromolecules underlines great supremacy over non-exosomal encapsulated delivery, accumulation, potency. Various studies cell lines animals give prominence exosome-based nanoparticles (NPs) promising alternative approach management cancer.
Язык: Английский
Процитировано
30