Emerging nanoparticle platforms for CpG oligonucleotide delivery DOI
Mingqiang Li,

Haochen Yao,

Ke Yi

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(9), P. 2203 - 2228

Published: Jan. 1, 2024

Unmethylated cytosine-phosphate-guanine (CpG) oligodeoxynucleotides (ODNs), which were therapeutic DNA with high immunostimulatory activity, have been applied in widespread applications from basic research to clinics as agents for cancer immunotherapy, viral infection, allergic diseases and asthma since their discovery 1995. The major factors consider clinical translation using CpG motifs are the protection of ODNs DNase degradation delivery Toll-like receptor-9 expressed human B-cells plasmacytoid dendritic cells. Therefore, great efforts devoted advances efficient systems ODNs. In this review, we outline new horizons recent developments field, providing a comprehensive summary nanoparticle-based developed improve efficacy CpG-mediated immune responses, including nanostructures, inorganic nanoparticles, polymer metal-organic-frameworks, lipid-based nanosystems, proteins peptides, well exosomes cell membrane nanoparticles. Moreover, future challenges establishment immunotherapeutic discussed. We expect that continuously growing interest development CpG-based immunotherapy will certainly fuel excitement stimulation medicine research.

Language: Английский

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds DOI
Yafei Zhang, Yuning Zhang, Rui Ding

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Language: Английский

Citations

18
Recent advances in self-targeting natural product-based nanomedicines DOI Creative Commons

Haifan Liu,

Xingyue Jin, Suyi Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

Citations

4
Brain-Targeting Drug Delivery Systems: The State Of The Art In Treatment Of Glioblastoma DOI Creative Commons

Bo Sun,

Rong Li, Ning Ji

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101443 - 101443

Published: Jan. 5, 2025

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and poor prognosis. The blood-brain barrier (BBB) blood-tumor (BTB) present significant obstacles to efficacy of tumor-targeted pharmacotherapy, thereby impeding therapeutic potential numerous candidate drugs. Targeting delivery adequate doses drug across BBB treat GBM has become prominent research area in recent years. This emphasis driven exploration evaluation diverse technologies for with some already undergoing clinical trials. review provides thorough overview advancements challenges targeted treatment. It specifically emphasizes systemic administration strategies assess their limitations Furthermore, this highlights promising future directions development intelligent systems aimed at overcoming current enhancing against GBM. These not only support foundational on but also offer methodological approaches applications.

Language: Английский

Citations

3
Tumor‐Associated Macrophages Nano‐Reprogrammers Induce “Gear Effect” to Empower Glioblastoma Immunotherapy DOI Open Access
Yang Wang, Guangzhe Li,

Jianlong Su

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Glioblastoma (GBM), the most malignant brain tumor with high prevalence, remains highly resistant to existing immunotherapies due significant immunosuppression within microenvironment (TME), predominantly manipulated by M2‐phenotypic tumor‐associated macrophages (M2‐TAMs). Here in this work, an M2‐TAMs targeted nano‐reprogrammers, MG5‐S‐IMDQ, is established decorating mannose molecule as targeting moiety well toll‐like receptor (TLR) 7/8 agonist, imidazoquinoline (IMDQ) on dendrimeric nanoscaffold. MG5‐S‐IMDQ demonstrated excellent capacity of penetrating blood‐brain barrier (BBB) selectively GBM microenvironment, leading a phenotype transformation and function restoration TAMs shown heightened phagocytic activity toward cells, enhanced cytotoxic effects, improved antigen cross‐presentation capability. In meantime, induction function‐oriented “gear effect”, treatment extended its impact systemically enhancing infiltration type I conventional dendritic cells (cDC1s) into sites bolstering adaptive immune responses. sum, precisely working unique target situ, nano‐reprogrammers successfully robust network that worked synergistically combat tumors. This facile nanoplatform‐based immunomodulatory strategy, serving powerful convenient monotherapy or complementary alongside other therapies like surgery, provided deep insights for advancing translational study GBM.

Language: Английский

Citations

2
Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases DOI
Muhammad Ismail, Jiayi Liu,

Ningyang Wang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138

Published: Jan. 28, 2025

Language: Английский

Citations

2
Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9 DOI Creative Commons
Qingyu Zhao, Yong Li,

Qian Sun

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101606 - 101606

Published: Feb. 27, 2025

Language: Английский

Citations

2
Micro/nanosystems for controllable drug delivery to the brain DOI Creative Commons

Mingzhen Tian,

Zhichao Ma, Guang‐Zhong Yang

et al.

The Innovation, Journal Year: 2023, Volume and Issue: 5(1), P. 100548 - 100548

Published: Nov. 27, 2023

•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.

Language: Английский

Citations

34
Tailored Apoptotic Vesicle Delivery Platform for Inflammatory Regulation and Tissue Repair to Ameliorate Ischemic Stroke DOI
Yang You,

Jianpei Xu,

Yipu Liu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 8646 - 8662

Published: April 26, 2023

Apoptotic vesicles (ApoVs) hold great promise for inflammatory regulation and tissue repair. However, little effort has been dedicated to developing ApoV-based drug delivery platforms, while the insufficient targeting capability of ApoVs also limits their clinical applications. This work presents a platform architecture that integrates apoptosis induction, loading, functionalized proteome regulation, followed by modification, enabling creation an apoptotic vesicle system treat ischemic stroke. Briefly, α-mangostin (α-M) was utilized induce mesenchymal stem cell (MSC) being loaded onto MSC-derived as anti-oxidant anti-inflammatory agent cerebral ischemia/reperfusion injury. Matrix metalloproteinase activatable cell-penetrating peptide (MAP), microenvironment-responsive peptide, modified on surface obtain MAP-functionalized α-M-loaded ApoVs. Such engineered targeted injured brain after systemic injection achieved enhanced neuroprotective activity due synergistic effect α-M. The internal protein payloads ApoVs, upon α-M activation, were found engaged in regulating immunological response, angiogenesis, proliferation, all which contributed therapeutic effects findings provide universal framework creating systems amelioration diseases demonstrate potential neural

Language: Английский

Citations

33
Access to the CNS: Strategies to overcome the BBB DOI Creative Commons
Bárbara Sánchez-Dengra, Isabel González‐Álvarez, Marival Bermejo

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 636, P. 122759 - 122759

Published: Feb. 20, 2023

The blood-brain barrier (BBB) limits the access of substances to central nervous system (CNS) which hinders treatment pathologies affecting brain and spinal cord. Nowadays, research is focus on new strategies overcome BBB can treat CNS are needed. In this review, different that allow increase analysed extended commented, not only invasive but also non-invasive ones. techniques include direct injection into parenchyma or CSF therapeutic opening BBB, while use alternative routes administration (nose-to-brain route), inhibition efflux transporters (as it important prevent drug from enhance efficiency), chemical modification molecules (prodrugs delivery systems (CDDS)) nanocarriers. future, knowledge about nanocarriers diseases will continue increase, other such as repurposing reprofiling, cheaper less time consuming, may limit its transfer society. main conclusion combination be most interesting approach CNS.

Language: Английский

Citations

32
Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer DOI Creative Commons
Dimitrios Ι. Avgoulas, Konstantinos S. Tasioulis, Rigini Papi

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1439 - 1439

Published: May 8, 2023

Cancer is designated as one of the principal causes mortality universally. Among different types cancer, brain cancer remains most challenging due to its aggressiveness, ineffective permeation ability drugs through blood–brain barrier (BBB), and drug resistance. To overcome aforementioned issues in fighting there an imperative need for designing novel therapeutic approaches. Exosomes have been proposed prospective “Trojan horse” nanocarriers anticancer theranostics owing their biocompatibility, increased stability, permeability, negligible immunogenicity, prolonged circulation time, high loading capacity. This review provides a comprehensive discussion on biological properties, physicochemical characteristics, isolation methods, biogenesis internalization exosomes, while it emphasizes diagnostic potential vehicle systems highlighting recent advances research field. A comparison activity effectiveness several exosome-encapsulated cargo including biomacromolecules underlines great supremacy over non-exosomal encapsulated delivery, accumulation, potency. Various studies cell lines animals give prominence exosome-based nanoparticles (NPs) promising alternative approach management cancer.

Language: Английский

Citations

28