Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Авг. 29, 2024
The
balance
of
programmed
cell
death
(PCD)
mechanisms,
including
apoptosis,
autophagy,
necroptosis
and
others,
is
pivotal
in
cancer
progression
treatment.
Dysregulation
these
pathways
results
uncontrolled
growth
resistance
to
conventional
therapies.
Nanomedicine
offers
a
promising
solution
oncology
through
targeted
drug
delivery
enabling
precise
targeting
cells
while
preserving
healthy
tissues.
This
approach
reduces
the
side
effects
traditional
chemotherapy
enhances
treatment
efficacy
by
engaging
PCD
pathways.
We
details
each
pathway,
their
innovative
nanomedicine
strategies
activate
pathways,
thereby
enhancing
therapeutic
specificity
minimizing
harm
precision
nanotechnology
promises
significant
improvements
outcomes.
synergy
between
activation
could
lead
more
effective
less
toxic
therapies,
heralding
new
era
Chemical Reviews,
Год журнала:
2024,
Номер
124(3), С. 929 - 1033
Опубликована: Янв. 29, 2024
RNA-based
therapies
have
catalyzed
a
revolutionary
transformation
in
the
biomedical
landscape,
offering
unprecedented
potential
disease
prevention
and
treatment.
However,
despite
their
remarkable
achievements,
these
encounter
substantial
challenges
including
low
stability,
susceptibility
to
degradation
by
nucleases,
prominent
negative
charge,
thereby
hindering
further
development.
Chemically
modified
platforms
emerged
as
strategic
innovation,
focusing
on
precise
alterations
either
RNA
moieties
or
associated
delivery
vectors.
This
comprehensive
review
delves
into
platforms,
underscoring
significance
augmenting
performance
translational
prospects
of
therapeutics.
It
encompasses
an
in-depth
analysis
various
chemically
that
been
instrumental
propelling
therapeutics
toward
clinical
utility.
Moreover,
scrutinizes
rationale
behind
diverse
chemical
modification
techniques
aiming
at
optimizing
therapeutic
efficacy
molecules,
facilitating
robust
management.
Recent
empirical
studies
corroborating
enhancement
through
modifications
are
highlighted.
Conclusively,
we
offer
profound
insights
transformative
impact
drugs
delineates
prospective
trajectories
for
future
development
integration.
ACS Nano,
Год журнала:
2024,
Номер
18(3), С. 1846 - 1864
Опубликована: Янв. 5, 2024
Mutation
burden,
hypoxia,
and
immunoediting
contribute
to
altered
metabolic
profiles
in
tumor
cells,
resulting
a
microenvironment
(TME)
characterized
by
accumulation
of
toxic
metabolites
depletion
various
nutrients,
which
significantly
hinder
the
antitumor
immunity
via
multiple
mechanisms,
hindering
efficacy
immunotherapies.
In-depth
investigation
mechanisms
underlying
these
phenomena
are
vital
for
developing
effective
drugs
therapies,
while
therapeutic
effects
metabolism-targeting
restricted
off-target
toxicity
toward
effector
immune
cells
high
dosage-mediated
side
effects.
Nanotechnologies,
exhibit
versatility
plasticity
targeted
delivery
metabolism
modulation,
have
been
widely
applied
boost
immunometabolic
therapies
strategies,
including
targeting
pathways.
In
this
review,
recent
advances
understanding
roles
cell
both
immunoevasion
immunosuppression
reviewed,
nanotechnology-based
reprogramming
strategies
enhanced
immunotherapies
discussed.
Nanoscale,
Год журнала:
2024,
Номер
16(9), С. 4378 - 4391
Опубликована: Янв. 1, 2024
Schematic
illustration
of
the
combinational
strategy
nanotechnology
and
PROTACs
(Nano-PROTACs):
typical
shortcomings
traditional
nanotechnology-based
strategies
for
PROTAC
drugs
optimization.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(6), С. 2402 - 2427
Опубликована: Янв. 21, 2024
Targeted
protein
degradation
(TPD)
represented
by
proteolysis
targeting
chimeras
(PROTACs)
marks
a
significant
stride
in
drug
discovery.
A
plethora
of
innovative
technologies
inspired
PROTAC
have
not
only
revolutionized
the
landscape
TPD
but
potential
to
unlock
functionalities
beyond
degradation.
Non-small-molecule-based
approaches
play
an
irreplaceable
role
this
field.
wide
variety
agents
spanning
broad
chemical
spectrum,
including
peptides,
nucleic
acids,
antibodies,
and
even
vaccines,
which
prove
instrumental
overcoming
constraints
conventional
small
molecule
entities
also
provided
rapidly
renewing
paradigms.
Herein
we
summarize
burgeoning
non-small
technological
platforms
PROTACs,
three
major
trajectories,
provide
insights
for
design
strategies
based
on
novel
Abstract
Nucleic
acid
aptamers,
often
termed
“chemical
antibodies,”
are
short,
single‐stranded
DNA
or
RNA
molecules,
which
selected
by
SELEX.
In
addition
to
their
high
specificity
and
affinity
comparable
traditional
antibodies,
aptamers
have
numerous
unique
advantages
such
as
wider
identification
of
targets,
none
low
batch‐to‐batch
variations,
versatile
chemical
modifications,
rapid
mass
production,
lack
immunogenicity.
These
characteristics
make
a
promising
recognition
probe
for
scientific
research
even
clinical
application.
Aptamer‐functionalized
nanomaterials
now
emerged
drug
delivery
system
various
diseases
with
decreased
side‐effects
improved
efficacy.
this
review,
the
technological
strategies
generating
high‐affinity
biostable
introduced.
Moreover,
development
application
in
biomedicine
including
aptamer‐based
biosensors,
aptamer–drug
conjugates
aptamer
functionalized
is
comprehensively
summarized.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(13), С. 6830 - 6859
Опубликована: Янв. 1, 2024
This
review
presents
the
recent
progress
on
aptamers
that
have
been
explored
for
SARS-CoV-2
detection
and
therapeutics,
wherein
construction
principles
characteristics
of
aptamer-based
assembly
systems
are
systematically
summarized.
Acta Materia Medica,
Год журнала:
2024,
Номер
3(1)
Опубликована: Янв. 1, 2024
PROTAC,
as
a
novel
therapeutic
drug
model,
has
received
widespread
attention
from
the
academic
and
pharmaceutical
industries.
At
same
time,
PROTAC
technology
led
many
researchers
to
focus
on
developing
chemical
biology
tool
properties
due
its
unique
operating
mechanism
protein
dynamic
regulatory
properties.
In
recent
years,
rapid
development
of
gradually
made
it
an
essential
for
target
identification
validation.
To
further
promote
application
tools
in
discovery
basic
medical
sciences
research,
this
review
distinguished
between
validation
concepts.
It
summarized
research
progress
these
aspects.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
275, С. 133680 - 133680
Опубликована: Июль 4, 2024
Proteolysis
targeting
chimeras
(PROTACs)
can
use
the
intrinsic
protein
degradation
system
in
cells
to
degrade
pathogenic
target
proteins,
and
are
currently
a
revolutionary
frontier
of
development
strategy
for
tumor
treatment
with
small
molecules.
However,
poor
water
solubility,
low
cellular
permeability,
off-target
side
effects
most
PROTACs
have
prevented
them
from
passing
preclinical
research
stage
drug
development.
This
requires
appropriate
delivery
systems
overcome
these
challenging
hurdles
ensure
precise
towards
site.
Therefore,
combination
multifunctional
will
open
up
new
directions
targeted
proteins.
In
this
review,
we
systematically
reviewed
design
principles
recent
advances
various
systems.
Moreover,
constructive
strategies
developing
were
proposed
comprehensively.
review
aims
deepen
understanding
drugs
promote
further
system.
