Heliyon,
Год журнала:
2023,
Номер
9(9), С. e19799 - e19799
Опубликована: Сен. 1, 2023
Ferroptosis
was
first
proposed
in
2012,
a
new
form
of
cell
death.
Autophagy
plays
crucial
role
clearance
and
maintaining
homeostasis.
is
involved
the
initial
step
ferroptosis
under
action
histone
elements
such
as
NCOA4,
RAB7A,
BECN1.
autophagy
are
tumor
progression,
treatment,
drug
resistance
microenvironment.
In
this
review,
we
described
mechanisms
ferroptosis,
autophagy,
immunotherapy,
respectively,
emphasized
relationship
between
autophagy-related
tumor.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Апрель 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 12, 2023
Abstract
Natural
living
materials
serving
as
biotherapeutics
exhibit
great
potential
for
treating
various
diseases
owing
to
their
immunoactivity,
tissue
targeting,
and
other
biological
activities.
In
this
review,
the
recent
developments
in
engineered
materials,
including
mammalian
cells,
bacteria,
viruses,
fungi,
microalgae,
plants,
active
derivatives
that
are
used
summarized.
Further,
future
perspectives
challenges
of
such
material‐based
discussed
provide
considerations
advances
biomedical
applications.
Advanced Materials,
Год журнала:
2024,
Номер
36(25)
Опубликована: Март 16, 2024
The
immunosuppressive
tumor
microenvironment
(TME)
is
a
huge
hurdle
in
immunotherapy.
Sono-immunotherapy
new
treatment
modality
that
can
reverse
TME,
but
the
sonodynamic
effects
are
compromised
by
overexpressed
glutathione
(GSH)
and
hypoxia
TME.
Herein,
this
work
reports
sono-immunotherapy
strategy
using
Pd
Advanced Materials,
Год журнала:
2023,
Номер
35(51)
Опубликована: Май 5, 2023
Abstract
Recently,
2D
transition
metal
carbide,
nitride,
and
carbonitrides
(MXenes)
materials
stand
out
in
the
field
of
tumor
therapy,
particularly
construction
functional
platforms
for
optimal
antitumor
therapy
due
to
their
high
specific
surface
area,
tunable
performance,
strong
absorption
near‐infrared
light
as
well
preferable
plasmon
resonance
effect.
In
this
review,
progress
MXene‐mediated
is
summarized
after
appropriate
modifications
or
integration
procedures.
The
enhanced
treatments
directly
performed
by
MXenes,
significant
improving
effect
MXenes
on
different
therapies,
imaging‐guided
strategies
are
discussed
detail.
Moreover,
existing
challenges
future
development
directions
presented.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(15), С. 10217 - 10233
Опубликована: Апрель 2, 2024
Although
immunotherapy
is
relatively
effective
in
treating
hematological
malignancies,
their
efficacy
against
solid
tumors
still
suboptimal
or
even
noneffective
presently.
Compared
to
cancers,
exhibit
strikingly
different
immunosuppressive
microenvironment,
severely
deteriorating
the
of
immunotherapy:
(1)
chemical
features
such
as
hypoxia
and
mild
acidity
suppress
activity
immune
cells,
(2)
pro-tumorigenic
domestication
cells
microenvironment
within
further
undermines
effectiveness
immunotherapy,
(3)
dense
physical
barrier
tumor
tissues
prevents
intratumoral
infiltration
contact
killing
active
cells.
Therefore,
we
believe
that
reversing
are
critical
priority
for
tumors.
Due
unique
morphologies,
structures,
compositions,
nanomedicines
have
become
powerful
tools
achieving
this
goal.
In
Perspective,
will
first
briefly
introduce
then
summarize
most
recent
progresses
nanomedicine-based
by
remodeling
immune-microenvironment
a
comprehensive
manner.
It
highly
expected
Perspective
aid
advancing
tumors,
optimistic
on
future
development
burgeoning
field.
Abstract
Cell
membrane‐coated
nanoparticles
(CMNPs)
have
recently
emerged
as
a
promising
platform
for
cancer
therapy.
By
encapsulating
therapeutic
agents
within
cell
membrane‐derived
coating,
these
combine
the
advantages
of
synthetic
and
natural
membranes.
This
review
provides
comprehensive
overview
recent
advancements
in
utilizing
CMNPs
effective
drug
delivery
vehicles
The
synthesis
fabrication
methods
are
comprehensively
discussed.
Various
techniques,
such
extrusion,
sonication,
self‐assembly,
employed
to
coat
with
membranes
derived
from
different
types.
membrane
coating
enables
biocompatibility,
reducing
risk
an
immune
response
enhancing
stability
bloodstream.
Moreover,
functionalization
strategies
CMNPs,
primarily
chemical
modification,
genetic
engineering,
external
stimuli,
highlighted.
presence
specific
surface
markers
on
coated
allows
targeted
cells
maximizes
efficacy.
Preclinical
studies
therapy
demonstrated
successful
various
agents,
chemotherapeutic
drugs,
nucleic
acids,
immunotherapeutic
using
CMNPs.
Furthermore,
article
explores
future
directions
challenges
this
technology
while
offering
insights
into
its
clinical
potential.
ACS Nano,
Год журнала:
2024,
Номер
18(3), С. 1846 - 1864
Опубликована: Янв. 5, 2024
Mutation
burden,
hypoxia,
and
immunoediting
contribute
to
altered
metabolic
profiles
in
tumor
cells,
resulting
a
microenvironment
(TME)
characterized
by
accumulation
of
toxic
metabolites
depletion
various
nutrients,
which
significantly
hinder
the
antitumor
immunity
via
multiple
mechanisms,
hindering
efficacy
immunotherapies.
In-depth
investigation
mechanisms
underlying
these
phenomena
are
vital
for
developing
effective
drugs
therapies,
while
therapeutic
effects
metabolism-targeting
restricted
off-target
toxicity
toward
effector
immune
cells
high
dosage-mediated
side
effects.
Nanotechnologies,
exhibit
versatility
plasticity
targeted
delivery
metabolism
modulation,
have
been
widely
applied
boost
immunometabolic
therapies
strategies,
including
targeting
pathways.
In
this
review,
recent
advances
understanding
roles
cell
both
immunoevasion
immunosuppression
reviewed,
nanotechnology-based
reprogramming
strategies
enhanced
immunotherapies
discussed.
Advanced Materials,
Год журнала:
2024,
Номер
36(23)
Опубликована: Март 4, 2024
Abstract
Dendritic
cell
(DC)
maturation
is
a
crucial
process
for
antigen
presentation
and
the
initiation
of
T
cell‐mediated
immune
responses.
Toll‐like
receptors
play
pivotal
roles
in
stimulating
DC
promoting
presentation.
Here,
novel
message
RNA
(mRNA)
cancer
vaccine
reported
that
boosts
antitumor
efficacy
by
codelivering
an
mRNA
encoding
tumor
TLR7/8
agonist
(R848)
to
using
supramolecular
lipid
nanoparticles
(SMLNP)
as
delivery
platform,
which
new
ionizable
(N2‐3L)
remarkably
enhances
translation
efficiency
β‐cyclodextrin
(β‐CD)‐modified
(Lip‐CD)
encapsulates
R848.
The
incorporation
R848
adjuvant
into
through
noncovalent
host–guest
complexation
significantly
promotes
after
vaccination,
thus
resulting
superior
vivo.
Moreover,
further
boosted
synergized
with
checkpoint
blockade
potentiating
anticancer
capability
cytotoxic
lymphocytes
infiltrated
sites.
This
work
indicates
SMLNP
shows
brilliant
potential
next‐generation
system
development
vaccines
high
efficacy.
Abstract
Oxygen
(O
2
),
nitric
oxide
(NO),
carbon
monoxide
(CO),
hydrogen
sulfide
(H
S),
and
)
with
direct
effects,
dioxide
(CO
complementary
effects
on
the
condition
of
various
diseases
are
known
as
therapeutic
gases.
The
targeted
delivery
in
situ
generation
these
gases
controllable
release
at
site
disease
has
attracted
attention
to
avoid
risk
gas
poisoning
improve
their
performance
treating
such
cancer
therapy,
cardiovascular
bone
tissue
engineering,
wound
healing.
Stimuli‐responsive
gas‐generating
sources
systems
based
biomaterials
that
enable
on‐demand
promising
approaches
for
precise
therapy.
This
work
highlights
current
advances
design
development
new
generate
deliver
behavior.
delivered
biomedical
applications
is
then
discussed.
