Swarming magnetic nanorobots bio-interfaced by heparinoid-polymer brushes for in vivo safe synergistic thrombolysis

Science Advances, Год журнала: 2023, Номер 9(48)

Опубликована: Ноя. 29, 2023

Biocompatible swarming magnetic nanorobots that work in blood vessels for safe and efficient targeted thrombolytic therapy vivo are demonstrated. This is achieved by using beads elaborately grafted with heparinoid-polymer brushes (HPBs) upon the application of an alternating field B ( t ). Because dense surface charges bestowed HPBs, demonstrate reversible agglomeration-free reconfigurations, low hemolysis, anti-bioadhesion, self-anticoagulation high-ionic-strength environments. They confirmed vitro to perform synergistic thrombolysis efficiently “motile-targeting” drug delivery mechanical destruction. Moreover, completion removal ), disassemble into dispersed particles blood, allowing them safely participate circulation be phagocytized immune cells without apparent organ damage or inflammatory lesion. provides a rational multifaceted HPB biointerfacing design strategy biomedical general motile platform deliver drugs therapies.

Язык: Английский

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Stimuli-Responsive Functional Micro-/Nanorobots: A Review

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15254 - 15276

Опубликована: Авг. 3, 2023

Stimuli-responsive functional micro-/nanorobots (srFM/Ns) are a class of intelligent, efficient, and promising microrobots that can react to external stimuli (such as temperature, light, ultrasound, pH, ion, magnetic field) perform designated tasks. Through adaptive transformation into the corresponding forms, they perfectly match demands depending on different applications, which manifest extremely important roles in targeted therapy, biological detection, tissue engineering, other fields. Promising srFM/Ns be, few reviews have focused them. It is therefore necessary provide an overview current development these intelligent clear inspiration for further this field. Hence, review summarizes advances stimuli-responsive regarding their response mechanism, achieved functions, applications highlight pros cons stimuli. Finally, we emphasize existing challenges propose possible strategies help accelerate study field promote toward actual applications.

Язык: Английский

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Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2553 - 2582

Опубликована: Март 4, 2024

The intricate and complex features of enzymatic reaction networks (ERNs) play a key role in the emergence sustenance life. Constructing such vitro enables stepwise build up complexity introduces opportunity to control activity using physicochemical stimuli. Rational design modulation network motifs enable engineering artificial systems with emergent functionalities. Such functional are useful for variety reasons as creating new-to-nature dynamic materials, producing value-added chemicals, constructing metabolic modules synthetic cells, even enabling molecular computation. In this review, we offer insights into chemical characteristics ERNs while also delving their potential applications associated challenges.

Язык: Английский

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Polyoxometalate‐Nanozyme‐Integrated Nanomotors (POMotors) for Self‐Propulsion‐Promoted Synergistic Photothermal‐Catalytic Tumor Therapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(6)

Опубликована: Дек. 20, 2023

Enzyme-powered nanomotors have demonstrated promising potential in biomedical applications, especially for catalytic tumor therapy, owing to their ability of self-propulsion and bio-catalysis. However, the fragility natural enzymes limits environmental adaptability also therapeutic efficacy catalysis-enabled therapy. Herein, polyoxometalate-nanozyme-based light-driven were designed synthesized targeted synergistic photothermal-catalytic In this construct, peroxidase-like activity P

Язык: Английский

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Open Questions of Chemically Powered Nano- and Micromotors

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(50), С. 27185 - 27197

Опубликована: Дек. 8, 2023

Chemically powered nano- and micromotors are microscopic devices that convert chemical energy into motion. Interest in these motors has grown over the past 20 years because they exhibit interesting collective behaviors have found potential uses biomedical environmental applications. Understanding how operate both individually collectively environments affect their operation is of fundamental applied significance. However, there still significant gaps our knowledge. This Perspective highlights several open questions regarding propulsion mechanisms of, interactions among, impact confinements on driven by self-generated gradients. These based my own experience as an experimentalist. For each question, I describe problem its significance, analyze status-quo, identify bottleneck problem, propose solutions. An underlying theme for interplay among reaction kinetics, physicochemical distributions, fluid flows. Unraveling this requires careful measurements well a close collaboration between experimentalists theoreticians/numerical experts. The interdisciplinary nature challenges suggests solutions could bring new revelations opportunities across disciplines such colloidal sciences, material soft matter physics, robotics, beyond.

Язык: Английский

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Covalent Organic Framework‐Based Nanomotor for Multimodal Cancer Photo‐Theranostics

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(30)

Опубликована: Авг. 9, 2023

Developing efficient integrated diagnosis and treatment agents based on fuel-free self-movement nanomotors remains challenging in antitumor therapy. In this study, a covalent organic framework (COF)-based biomimetic nanomotor composed of polypyrrole (PPy) core, porphyrin-COF shell, HCT116 cancer cell membrane coating is reported. Under near-infrared (NIR) light irradiation, the obtained mPPy@COF-Por can overcome Brownian motion achieves directional through self-thermophoretic force generated from PPy core. The enables to selectively recognize source lines reduces bio-adhesion biological medium, endowing with NIR light-powered good mobility. More importantly, such multifunctional integration allows COF-based be powerful nanoagent for treatment, high infrared thermal imaging/photoacoustic imaging/fluorescence trimodal imaging-guided combined photothermal/photodynamic therapeutic effect tumor successfully achieved. results offer considerable promise development COF imaging/therapy modalities biomedical applications.

Язык: Английский

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Nitric Oxide‐Actuated Titanium Dioxide Janus Nanoparticles for Enhanced Multimodal Disruption of Infectious Biofilms

Advanced Functional Materials, Год журнала: 2024, Номер 34(45)

Опубликована: Июнь 28, 2024

Abstract Sonodynamic therapy (SDT) is promising for combating deep‐seated infectious diseases by generating substantial reactive oxygen species (ROS) through the profound tissue penetration capabilities of ultrasound. However, compact protective structures bacterial biofilms present a formidable challenge, impeding ROS efficacy. Given that have limited diffusion range and current sonosensitizers struggle to infiltrate biofilms, complete eradication pathogenic bacteria often remains unachieved. In this study, mesoporous titanium dioxide (TiO 2 ) nanoparticles are engineered asymmetrically coated with thin layer Ag loaded L‐arginine (LA) construct ultrasound‐propelled nanomotors. These Ag‐TiO ‐LA Janus demonstrate robust self‐propulsion upon ultrasonic activation, allowing deeper into biofilm matrices enhancing localized disruption improved SDT outcomes. Additionally, incorporation not only broadens TiO ’s absorption spectrum but also confers photothermal NIR laser excitation at 808 nm. The nanomotor amalgamates sonodynamic potential Ag's properties, forging versatile antimicrobial agent capable efficient synergistic antibacterial effect when subjected dual ultrasound stimuli. This innovative, singularly‐structured nanoparticle stands out as an effective combatant against accelerates healing process infected wounds, showcasing multifaceted clinical applications.

Язык: Английский

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Hyperglycemia Targeting Nanomotors for Accelerated Healing of Diabetic Wounds by Efficient Microenvironment Remodeling

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Abstract Multifunctional nanoagents are robust to remodel environments for managing chronic diabetic wounds. However, their delivery primarily relies on Brownian motion and randomly enhanced diffusion. Here, taking advantage of wound heterogeneity, such as the uneven distribution glucose, hyperglycemia targeting nanomotors proposed. They capable efficiently hyperglycemic interfaces in wounds significantly accelerating healing by employing endogenous glucose‐activated cascade reactions responding local glucose gradients. Compared previous counterparts, they show a four‐fold enhancement effective coverage within 60 s multiplied accumulation at interfaces, facilitating deep penetration. Correspondingly, downregulation levels is apparently enhanced, while pH‐lowering oxygen‐supplying both improved. In comparison counterparts delivered passive diffusion diffusion, nanomotor‐based spray accelerates upon mice approximately 30% 23%, resulting from restricted inflammatory response, reactive oxygen species (ROS) scavenging elevated vascular endothelial growth factor (VEGF). This study presents generally efficient approach targeted management utilizing which can be extended other therapeutic systems.

Язык: Английский

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Photothermal‐Driven α‐Amylase‐Modified Polydopamine Pot‐Like Nanomotors for Enhancing Penetration and Elimination of Drug‐Resistant Biofilms

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Biological enzyme‐functionalized antibacterial nanoparticles, which can degrade biofilm and kill bacteria under mild reaction conditions, have attracted much attention for the elimination of deep‐seated bacterial infections. However, poor diffusion penetration capabilities recently developed biological nanoparticles in severely impair eradication efficacy bacteria. Herein, a photothermal‐driven nanomotor (denoted as APPNM) is enhancing drug‐resistant biofilms The contained pot‐like polydopamine (PDA) nanostructure its outer surface chemically immobilized with layer α‐amylases. Under exposure to 808 nm near‐infrared (NIR) laser irradiation, self‐propelled nanomotors, integrating α‐amylases destroy compact structure biofilms, penetrate deeply into effectively eliminate them. Subsequently, they accumulate on using inherent bio‐adhesion property PDA, thereby completely eradicating by photothermal effect. These synergistic effects enable them exhibit superior antibiofilm produce remarkable therapeutic accelerated wound healing vivo. With excellent biocompatibility, as‐developed nanomotors great potential be applied treating biofilm‐related

Язык: Английский

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Gout management using uricase and sodium citrate hollow mesoporous nanomotors

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 8, 2025

Uricase (UOx)-based gout treatments are generally limited due in part to the accumulation of H2O2 an arthrosis environment characterized by a sluggish metabolism. Here we develop self-cascade nanomotor with high efficiency toward simultaneous uric acid (UA) degradation and elimination on basis UOx sodium citrate loading amine functionalized hollow mesoporous silica nanoparticles (AHMSNs). Due inherent asymmetry AHMSNs, developed nanomotors can be actuated ionic diffusiophoresis induced enzymatic UA degradation, thus enlarging diffusion range within joint cavity. generated during decomposition simultaneously eliminated loaded citrate, resulting considerable improvement mammalian cell viability. In vivo studies display powerful therapeutic effect gouty models using this system. These results present potential as active agents for gout, providing perspective application enzyme-driven micro/nanomotors. Uricase-based microenvironment. authors nanomotor-based strategy that degrades eliminate efficient therapy.

Язык: Английский

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