Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis

The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170962 - 170962

Опубликована: Фев. 13, 2024

Язык: Английский

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Co-exposure with cadmium elevates the toxicity of microplastics: Trojan horse effect from the perspective of intestinal barrier

Journal of Hazardous Materials, Год журнала: 2024, Номер 466, С. 133587 - 133587

Опубликована: Янв. 22, 2024

Язык: Английский

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Sesamin Alleviates Allergen-Induced Diarrhea by Restoring Gut Microbiota Composition and Intestinal Barrier Function

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Food allergens are the key triggers of allergic diarrhea, causing damage to immune-rich ileum. This weakens mucosal barrier and tight junctions, increases intestinal permeability, exacerbates allergen exposure, thereby worsening condition. Sesamin, a natural lignan isolated from sesame seed, has shown potential in regulating immune responses, but its effects on health remain unclear. In this study, we constructed an ovalbumin (OVA)-induced diarrhea mouse model, which demonstrated increased mast cell degranulation, reduced junction integrity, impaired function. Pro-inflammatory cytokines were significantly ileum, along with unbalanced cluster differentiation 4 (CD4

Язык: Английский

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Toxic vascular effects of polystyrene microplastic exposure

The Science of The Total Environment, Год журнала: 2023, Номер 905, С. 167215 - 167215

Опубликована: Сен. 19, 2023

Язык: Английский

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Association of specific gut microbiota with polyethylene microplastics caused gut dysbiosis and increased susceptibility to opportunistic pathogens in honeybees

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170642 - 170642

Опубликована: Фев. 5, 2024

Язык: Английский

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Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skin

Environment International, Год журнала: 2024, Номер 186, С. 108638 - 108638

Опубликована: Апрель 1, 2024

Microplastics (MPs) are pervasive pollutants in the natural environment and contribute to increased levels of illness both animals humans. However, specific impacts MPs on skin damage alopecia not yet well understood. In this study, we have examined effects two types polystyrene (pristine aged) hair follicle mice. UV irradiation changed chemical physical properties aged MPs, including functional groups, surface roughness, contact angles. vivo vitro experiments, cell injuries related oxidative stress, apoptosis, tight junctions (TJs), alopecia, mitochondrial dysfunction, other damages were observed. Mechanistically, can induce TJs via stress pathway inhibition antioxidant-related proteins, lead alopecia. The regulation apoptosis was also observed, is involved ROS-mediated signaling pathway. Importantly, showed exacerbated toxicity, which may be due their elevated irregularities altered compositions. Collectively, study suggests a potential therapeutic approach for caused by pollution.

Язык: Английский

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Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 279, С. 116455 - 116455

Опубликована: Май 20, 2024

Microplastics (MPs) pose a clear threat to aquatic organisms affecting their health. Their impact on liver homeostasis, as well the potential onset of nonalcoholic fatty disease (NAFLD), is still poorly investigated and remains almost unknown. The aim this study was evaluate outcomes subchronic exposure polystyrene MPs (PS-MPs; 1–20 μm; 0, 25, or 250 mg/kg b.w./day) lipid metabolism, inflammation, oxidative balance in gilthead seabreams (Sparus aurata Linnaeus, 1758) exposed for 21 days via contaminated food. PS-MPs induced an up-regulation mRNA levels crucial genes associated with synthesis storage (i.e., PPARy, Srebp1, Fasn) without modifications involved catabolism PPARα, HL, Pla2) transport metabolism (Fabp1) liver. increase CSF1R pro-inflammatory cytokines gene expression TNF-α IL-1β) also observed fish dose-dependent manner. These findings were confirmed by hepatic histological evaluations reporting evidence accumulation, necrosis. Moreover, caused impairment antioxidant defense system through alteration its enzymatic (catalase, superoxide dismutase, glutathione reductase) non-enzymatic (glutathione) components, resulting increased production reactive oxygen species (ROS) malondialdehyde (MDA), biomarkers damage. detoxifying enzymes inferred decreased Ethoxyresorufin-O-deethylase (EROD) activity glutathione-S-transferase (GST) at highest PS-MP dose. suggests that affect health seabream. dysfunction damage result from detrimental interplay damage, systems modifications, altering gut-liver axis homeostasis. This scenario suggestive involvement MP-induced effects progression

Язык: Английский

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Co-exposure of polystyrene nanoplastics and copper induces development toxicity and intestinal mitochondrial dysfunction in vivo and in vitro

The Science of The Total Environment, Год журнала: 2024, Номер 930, С. 172681 - 172681

Опубликована: Апрель 24, 2024

Язык: Английский

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Mesenchymal stem cell-derived exosomes promote tissue repair injury in rats with liver trauma by regulating gut microbiota and metabolism

Molecular and Cellular Probes, Год журнала: 2024, Номер 75, С. 101958 - 101958

Опубликована: Март 27, 2024

The effects of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-exos) on serum metabolites intestinal microbiota in rats after liver trauma were discussed. Adult Wistar Albino assigned into control, model (liver trauma), MSCs, MSC-exos groups (n = 6). study examined changes the inflammatory environment tissues analyzed by histological examination analysis macrophage phenotypes. Alterations determined untargeted metabonomics, gut composition was characterized 16S rDNA sequencing. Correlations between specific microbiota, metabolites, response calculated using Spearman correlation analysis. Rats with MSCs treatment exhibited attenuated infiltration necrosis tissues. reduced proportion M1 macrophages, accompanied a decrease inducible nitric oxide synthase (iNOS) tumor factor-alpha (TNF-α) levels. Furthermore, expanded M2 an increase arginase-1 (Arg-1) interleukin-10 (IL-10) beneficial MSC-exo superior to those MSC treatment. abundance altered pathological rats, whereas intervention partially restored metabolite alterations. At phylum level, alterations Bacteroidota, Proteobacteria, Verrucomicrobiota observed intervention. genus Intestinimonas, Alistipes, Aerococcus, Faecalibaculum, Lachnospiraceae_ND3007_group main differential microbiota. 6-Methylnicotinamide, N-Methylnicotinamide, Glutathione, oxidized, ISOBUTYRATE, ASCORBATE, EICOSAPENTAENOATE, GLYCEROL 3-PHOSPHATE, Ascorbate radical selected as important metabolites. There clear Ascorbate, Intestinimonas/Faecalibaculum cytokines. promoted repair tissue damage regulating providing new insights how inflammation trauma.

Язык: Английский

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Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet–Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis

Environmental Health Perspectives, Год журнала: 2024, Номер 132(9)

Опубликована: Сен. 1, 2024

Microplastics (MPs) have become a global environmental problem, emerging as contaminants with potentially alarming consequences. However, long-term exposure to polystyrene microspheres (PS-MS) and its effects on diet-induced obesity are not yet fully understood.

Язык: Английский

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