Environment International,
Journal Year:
2025,
Volume and Issue:
195, P. 109258 - 109258
Published: Jan. 1, 2025
Nanoplastics
(NPs)
have
attracted
widespread
attention
owing
to
their
presence
in
the
body.
Recent
studies
highlighted
detrimental
effects
of
NPs
on
digestive
tract.
However,
no
reported
an
association
between
exposure
and
colitis-associated
cancer
(CAC).
An
azoxymethane/dextran
sodium
sulfate-induced
CAC
model
was
used,
polystyrene
nanoparticles
(PS-NPs)
were
selected
for
long-term
exposure.
Non-targeted
metabolomics
16S
rRNA
sequencing
used
detect
changes
colonic
metabolites
gut
microbes
following
PS-NPs
A
lipopolysaccharide
(LPS)-treated
cell
(Caco-2)
exposed
investigate
underlying
molecular
mechanism.
Compared
normal
control
group,
mice
group
exhibited
more
tumor
nodes
reactive
oxygen
species
(ROS),
higher
expression
pan-CK
Ki-67,
severe
DNA
damage.
revealed
that
altered
abundance
Allobaculum
Lactobacillus,
whereas
metabolic
analysis
showed
most
significant
enriched
mostly
fatty
acid
metabolism.
Experiments
LPS
intervened
Caco-2
cells
led
lipid
peroxidation,
oxidative
stress,
damage
Caco-2.
Exposure
activated
phosphatidylinositol
3-kinase
(PI3K)/AKT/mammalian
target
rapamycin
(mTOR)
signaling
pathway
both
AOM/DSS
mouse
cellular
model.
Key
proteins
involved
metabolism
downregulated
PS-NPs.
The
significantly
inhibited
by
activation
fenofibrate.
disturbed
induced
via
PI3K/AKT/mTOR
promote
progression.
Inhibition
is
a
therapeutic
controlling
PS-NP-induced
CAC.
Our
study
provides
important
reference
prevention
treatment
from
perspective
environment
enhances
awareness
necessity
plastic
control.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Food
allergens
are
the
key
triggers
of
allergic
diarrhea,
causing
damage
to
immune-rich
ileum.
This
weakens
mucosal
barrier
and
tight
junctions,
increases
intestinal
permeability,
exacerbates
allergen
exposure,
thereby
worsening
condition.
Sesamin,
a
natural
lignan
isolated
from
sesame
seed,
has
shown
potential
in
regulating
immune
responses,
but
its
effects
on
health
remain
unclear.
In
this
study,
we
constructed
an
ovalbumin
(OVA)-induced
diarrhea
mouse
model,
which
demonstrated
increased
mast
cell
degranulation,
reduced
junction
integrity,
impaired
function.
Pro-inflammatory
cytokines
were
significantly
ileum,
along
with
unbalanced
cluster
differentiation
4
(CD4
Environment International,
Journal Year:
2024,
Volume and Issue:
186, P. 108638 - 108638
Published: April 1, 2024
Microplastics
(MPs)
are
pervasive
pollutants
in
the
natural
environment
and
contribute
to
increased
levels
of
illness
both
animals
humans.
However,
specific
impacts
MPs
on
skin
damage
alopecia
not
yet
well
understood.
In
this
study,
we
have
examined
effects
two
types
polystyrene
(pristine
aged)
hair
follicle
mice.
UV
irradiation
changed
chemical
physical
properties
aged
MPs,
including
functional
groups,
surface
roughness,
contact
angles.
vivo
vitro
experiments,
cell
injuries
related
oxidative
stress,
apoptosis,
tight
junctions
(TJs),
alopecia,
mitochondrial
dysfunction,
other
damages
were
observed.
Mechanistically,
can
induce
TJs
via
stress
pathway
inhibition
antioxidant-related
proteins,
lead
alopecia.
The
regulation
apoptosis
was
also
observed,
is
involved
ROS-mediated
signaling
pathway.
Importantly,
showed
exacerbated
toxicity,
which
may
be
due
their
elevated
irregularities
altered
compositions.
Collectively,
study
suggests
a
potential
therapeutic
approach
for
caused
by
pollution.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
279, P. 116455 - 116455
Published: May 20, 2024
Microplastics
(MPs)
pose
a
clear
threat
to
aquatic
organisms
affecting
their
health.
Their
impact
on
liver
homeostasis,
as
well
the
potential
onset
of
nonalcoholic
fatty
disease
(NAFLD),
is
still
poorly
investigated
and
remains
almost
unknown.
The
aim
this
study
was
evaluate
outcomes
subchronic
exposure
polystyrene
MPs
(PS-MPs;
1–20
μm;
0,
25,
or
250
mg/kg
b.w./day)
lipid
metabolism,
inflammation,
oxidative
balance
in
gilthead
seabreams
(Sparus
aurata
Linnaeus,
1758)
exposed
for
21
days
via
contaminated
food.
PS-MPs
induced
an
up-regulation
mRNA
levels
crucial
genes
associated
with
synthesis
storage
(i.e.,
PPARy,
Srebp1,
Fasn)
without
modifications
involved
catabolism
PPARα,
HL,
Pla2)
transport
metabolism
(Fabp1)
liver.
increase
CSF1R
pro-inflammatory
cytokines
gene
expression
TNF-α
IL-1β)
also
observed
fish
dose-dependent
manner.
These
findings
were
confirmed
by
hepatic
histological
evaluations
reporting
evidence
accumulation,
necrosis.
Moreover,
caused
impairment
antioxidant
defense
system
through
alteration
its
enzymatic
(catalase,
superoxide
dismutase,
glutathione
reductase)
non-enzymatic
(glutathione)
components,
resulting
increased
production
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
biomarkers
damage.
detoxifying
enzymes
inferred
decreased
Ethoxyresorufin-O-deethylase
(EROD)
activity
glutathione-S-transferase
(GST)
at
highest
PS-MP
dose.
suggests
that
affect
health
seabream.
dysfunction
damage
result
from
detrimental
interplay
damage,
systems
modifications,
altering
gut-liver
axis
homeostasis.
This
scenario
suggestive
involvement
MP-induced
effects
progression
Environmental Health Perspectives,
Journal Year:
2024,
Volume and Issue:
132(9)
Published: Sept. 1, 2024
Microplastics
(MPs)
have
become
a
global
environmental
problem,
emerging
as
contaminants
with
potentially
alarming
consequences.
However,
long-term
exposure
to
polystyrene
microspheres
(PS-MS)
and
its
effects
on
diet-induced
obesity
are
not
yet
fully
understood.
