Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 27, 2024
Abstract
By
integrating
magnetic
resonance-visible
components
with
scaffold
materials,
hydrogel
microspheres
(HMs)
become
visible
under
resonance
imaging(MRI),
allowing
for
non-invasive,
continuous,
and
dynamic
monitoring
of
the
distribution,
degradation,
relationship
HMs
local
tissues.
However,
when
these
visualization
are
physically
blended
into
HMs,
it
reduces
their
relaxation
rate
specificity
MRI,
weakening
efficacy
real-time
monitoring.
To
achieve
MRI-guided
in
vivo
tissue
repair
functionality,
we
utilized
airflow
control
photo-crosslinking
methods
to
prepare
alginate-gelatin-based
dual-network
(G-AlgMA
HMs)
using
gadolinium
ions
(Gd
(III)),
a
paramagnetic
MRI
contrast
agent,
as
crosslinker.
When
network
G-AlgMA
degrades,
cleavage
covalent
bonds
causes
release
Gd
(III),
continuously
altering
arrangement
movement
characteristics
surrounding
water
molecules.
This
change
transverse
longitudinal
times
results
variations
signal
values,
thus
enabling
HMs.
Additionally,
data
show
that
degradation
polypeptide
(K
2
(SL)
6
K
(KK))
from
promote
vascular
regeneration
soft
repair.
Overall,
enable
biomaterial
through
which
is
significant
understanding
material
mechanisms,
evaluating
biocompatibility,
optimizing
design.
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(11), С. 1623 - 1642
Опубликована: Ноя. 2, 2023
Tumors
pose
a
significant
global
economic
and
health
burden,
with
conventional
cancer
treatments
lacking
tumor
specificity,
leading
to
limited
efficiency
undesirable
side
effects.
Targeted
therapy
is
imminent.
Tumor
cells
produce
lactate
hydrogen
ions
(H
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(25), С. 6033 - 6062
Опубликована: Янв. 1, 2024
Gene-activated
matrices
are
versatile
and
novel
technologies
to
treat
skin
wounds.
This
approach
offers
a
promising
avenue
for
targeted
treatment
strategies
in
health
care.
BMB Reports,
Год журнала:
2024,
Номер
57(2), С. 71 - 78
Опубликована: Янв. 3, 2024
Melanoma
is
one
of
the
most
aggressive
skin
tumors,
and
conventional
treatment
modalities
are
not
effective
in
treating
advanced
melanoma.Although
immunotherapy
an
for
melanoma,
it
has
disadvantages,
such
as
a
poor
response
rate
serious
systemic
immune-related
toxic
side
effects.The
main
solution
to
this
problem
use
biological
materials
hydrogels
reduce
these
effects
amplify
immune
killing
effect
against
tumor
cells.Hydrogels
have
great
advantages
local
slow-release
drug
carriers,
including
ability
deliver
antitumor
drugs
directly
site,
enhance
concentration
tissue,
distribution
exhibit
good
degradability.Despite
advantages,
there
been
limited
research
on
application
melanoma
treatment.Therefore,
article
provides
comprehensive
review
potential
immunotherapy.Hydrogels
can
serve
carriers
sustained
delivery,
enabling
targeted
localized
delivery
with
minimal
effects.This
approach
improve
efficacy
melanoma.Thus,
vehicles
warrants
further
exploration.
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
As
Gastric
cancer
is
one
of
the
most
common
gastrointestinal
malignancies
in
China,
with
a
5‐year
relative
survival
rate
≈40%.
Therefore,
development
new
strategies
to
treat
gastric
becomes
urgent.
In
recent
years,
an
increasing
number
studies
have
found
that
all‐trans
retinoic
acid
(Tre)
can
induce
polarization
M2
macrophages
toward
M1
tumor
immune
microenvironment
(TIME),
and
therefore
play
due
role
this
treatment.
This
research
proposes
load
doxorubicin
(DOX)
Tre
mesoporous
silica,
which
then
loaded
into
sodium
alginate
slow‐release
Gel
obtain
final
product
(GEL‐MSDT).
Gel‐MSDT
sustained‐release
hydrogel
release
DOX
locally
tumor,
kill
cells,
immunogenic
death,
regulate
tumor‐associated
macrophage
phenotype,
promote
anti‐tumor
response.
coordinate
chemotherapy
immunotherapy,
delay
lasting
effect.
The
results
vitro
vivo
experiments
show
significantly
inhibit
growth,
providing
effective
strategy
for
treatment
cancer.
Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 512 - 512
Опубликована: Апрель 7, 2024
Disulfiram
(DSF)
degrades
to
diethyldithiocarbamate
(DTC)
in
vivo
and
coordinates
with
copper
ions
form
CuET,
which
has
higher
antitumor
activity.
In
this
study,
DSF@CuMSN-PDA
nanoparticles
were
prepared
using
mesoporous
silica
ions,
DSF
as
a
carrier,
polydopamine
(PDA)
gate
system.
The
selectively
released
CuET
into
tumor
tissue
by
taking
advantage
of
the
microenvironment,
where
PDA
could
be
degraded.
release
ratio
reached
79.17%
at
pH
5.0,
indicating
pH-responsive
drug
from
nanoparticles.
PDA-gated
system
provided
unique
photothermal
conversion
performance
significantly
improved
efficiency.
vivo,
experiments
showed
that
designed
combined
near-infrared
light
(808
nm,
1
W/cm2)
irradiation
effectively
inhibited
growth
HCT116
cells
harnessing
potential
chemotherapy
therapy;
synergistic
effect
was
achieved.
Taken
together,
these
results
suggest
construct
can
employed
promising
candidate
for
chemo-photothermal
therapy.
