ACS Materials Au,
Год журнала:
2025,
Номер
5(2), С. 377 - 384
Опубликована: Янв. 31, 2025
Single-atom
nanozymes
(SANs)
are
a
class
of
with
metal
centers
that
mimic
the
structure
metalloenzymes.
Herein,
we
report
synthesis
Zn–N–C
SAN,
which
mimics
action
natural
carbonic
anhydrase
enzyme.
The
two-step
annealing
technique
led
to
content
more
than
18
wt
%.
Since
act
as
active
sites,
this
high
loading
resulted
in
superior
catalytic
activity.
Zn-SAN
showed
CO2
uptake
2.3
mmol/g
and
final
conversion
bicarbonate
91%.
was
converted
via
biomimetic
process
by
allowing
its
adsorption
catalyst,
followed
addition
catalyst
HEPES
buffer
(pH
=
8)
start
into
HCO3–.
Afterward,
CaCl2
added
form
white
CaCO3
precipitate,
then
filtered,
dried,
weighed.
Active
carbon
MCM-41
were
used
controls
under
same
reaction
conditions.
According
findings,
sequestration
capacity
42
mg
CaCO3/mg
Zn-SAN.
Some
amino
acids
(AAs)
binding
affinity
for
Zn
able
suppress
enzymatic
activity
blocking
centers.
This
strategy
detection
His,
Cys,
Glu,
Asp
limits
0.011,
0.031,
0.029,
0.062
μM,
respectively,
hence
utilized
quantifying
these
AAs
commercial
dietary
supplements.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(33), С. 13663 - 13671
Опубликована: Авг. 10, 2024
Rapid
and
accurate
detection
of
human
epidermal
growth
factor
receptor
2
(HER2)
is
crucial
for
the
early
diagnosis
prognosis
breast
cancer.
In
this
study,
we
reported
an
iron-manganese
ion
N-doped
carbon
single-atom
catalyst
(FeMn-NC
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(13), С. 1515 - 1522
Опубликована: Март 9, 2024
Comprehensive
Summary
We
have
compiled
eight
promising
strategies
for
enhancing
the
specificity
and
selectivity
of
nanozymes,
as
depicted
in
comprehensive
summary
above.
Enzymes
exhibit
intricate
sophisticated
structures,
including
substrate
channels
active
sites,
which
can
inform
design
nanozymes.
Replication
these
structural
features
application
facet
engineering/doping
techniques
significantly
enhance
catalytic
Alternatively,
use
Molecularly
Imprinted
Polymers
(MIPs)
to
coat
nanozymes
represents
an
effective
approach
impart
specificity.
Furthermore,
several
straightforward
stopgap
been
devised
improve
nanozyme
analytical
applications,
such
integration
biorecognition
elements
sensor
arrays
through
surface
modification.
image
Key
Scientists
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
ACS Nano,
Год журнала:
2024,
Номер
18(37), С. 25865 - 25879
Опубликована: Сен. 2, 2024
Greatly
improving
the
sensitivity
and
detection
range
of
lateral
flow
immunoassays
(LFAs)
by
at
least
100
times
without
using
additional
instruments
remains
challenging.
Herein,
we
develop
a
three-dimensional
(3D)
film-like
nanozyme
(GO-Pt
Abstract
In
order
to
co‐immobilize
multiple
enzymes,
a
wide
range
of
nanomaterials
has
been
designed
achieve
synergistic
enzyme
activity
and
enhance
catalytic
efficiency.
Nanomaterials,
as
carriers
for
co‐immobilization,
possess
various
advantages
such
tunable
morphology
size,
high
specific
surface
area,
abundant
chemically
active
sites.
They
can
significantly
stability,
activity,
We
overview
the
commonly
used
methods
strategies
co‐immobilization.
This
review
further
summarizes
latest
research
advances
in
co‐immobilization
applications
over
past
5
years.
Meanwhile,
challenges
these
well
some
potential
future
directions
are
also
discussed.
