Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161853 - 161853
Опубликована: Март 1, 2025
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 11, 2024
Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.
Язык: Английский
Процитировано
22
Bioactive Materials, Год журнала: 2024, Номер 38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.
Язык: Английский
Процитировано
21
Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
16
Small, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Abstract The repair and reconstruction of large‐scale bone defects face enormous challenges because the failure to reconstruct osteo‐vascularization network. Herein, a near‐infrared (NIR) light‐responsive hydrogel system is reported achieve programmed tissue regeneration through synergetic effects on‐demand drug delivery mild heat stimulation. spatiotemporal (HG/MPa) composed polydopamine‐coated Ti 3 C 2 T x MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, potent angiogenic drug) hydroxypropyl chitosan/gelatin (HG) developed orchestrate network boost regeneration. Upon exposure NIR light irradiation, engineered HG/MPa can initial complete release aFGF induce rapid angiogenesis provide sufficient blood supply, maximizing its biofunction in defect area. This integrated demonstrated good therapeutic efficacy promoting cell adhesion, proliferation, migration, angiogenesis, osteogenic differentiation periodic irradiation. In vivo, animal experiments further revealed that spatiotemporalized platform synergized photothermal treatment significantly accelerated critical‐sized healing by increasing density, recruiting endogenous stem cells, facilitating production osteogenesis/angiogenesis‐related factors. Overall, smart‐responsive could enhance
Язык: Английский
Процитировано
12
Giant, Год журнала: 2024, Номер 18, С. 100251 - 100251
Опубликована: Март 6, 2024
The treatment of diabetic wounds is a major challenge faced by the medical system, and there growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential skin repair, regenerative properties primarily attributed paracrine effects secreted products, including exosomes. Compared cell-based approaches, using exosomes as cell-free therapy for chronic several advantages. Exosomes can regulate intercellular communication releasing their contents, mRNA, miRNA, lipids, proteins, which further promote are well explored biomedical application owing advantages such biocompatibility low immunogenicity. However, common method exosome administration through injection, but due rapid clearance rate body, maintaining necessary therapeutic concentration around challenging. Therefore, it develop new biocompatible scaffold carrier extracellular vesicles, allowing them sustain at non-healing sites continuously Engineered kinds modified internal treated molecules, surface decoration or delivered engineered platform. In addition, some researchers have processed exosomes, known decoration, delivery platforms. regular greater promoting this review, we summarize molecular mechanisms from different sources varying modifications Advantages limitations repair were also discussed. Finally, highlight challenges future development directions translating our knowledge into clinical practice.
Язык: Английский
Процитировано
11
Small, Год журнала: 2024, Номер 20(45)
Опубликована: Июль 25, 2024
Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.
Язык: Английский
Процитировано
11
Bioactive Materials, Год журнала: 2024, Номер 40, С. 212 - 226
Опубликована: Июнь 13, 2024
Язык: Английский
Процитировано
10
Deleted Journal, Год журнала: 2024, Номер 2(3)
Опубликована: Май 29, 2024
Abstract The skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. dynamic interactions between various cell types are essential for homeostasis function. Emerging research has unveiled significant role of extracellular vesicles (EVs) key mediators communication in regulating many aspects physiological pathological processes. In this review, we provide overview recent advances understanding roles EVs health, aging, diseases, discuss natural engineered disease treatment along potential challenges. burgeoning area may expand new therapeutic approaches disorders open avenues personalized skincare treatments.
Язык: Английский
Процитировано
8
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 672, С. 179 - 199
Опубликована: Май 29, 2024
Язык: Английский
Процитировано
8
Bioactive Materials, Год журнала: 2025, Номер 47, С. 266 - 282
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
1