Versatile Ce(III)‐Terephthalic Acid@Au Metal Organic Frameworks for ROS Elimination and Photothermal Sterilization DOI
Jing Wang,

Xue Wei,

Jian Chen

и другие.

ChemNanoMat, Год журнала: 2024, Номер 10(7)

Опубликована: Апрель 16, 2024

Abstract Nanozymes have been widely used for treating reactive oxygen species (ROS) caused diseases. However, the ROS‐dependent antibacterial property is inevitably damaged during process of scavenging ROS, which unfavorable treatment diseases related to both ROS accumulation and bacterial infections. To address issues, biomedical materials with ROS‐elimination ability ROS‐independent capacity are fabricated via in situ depositing spherical Au nanoparticles (Au NPs) on rough surface metal organic frameworks composed Ce(III) terephthalic acid (Ce‐BDC@Au MOFs). The synthesized Ce‐BDC@Au MOFs show multi‐enzymatic activities owing reversible conversion between Ce 3+ 4+ , can significantly scavenge cells. deposition NPs Ce‐BDC causes come close proximity forming plasmon resonance coupling, inducing wavelength red shifted NIR region. Based this, good photothermal efficiency under laser (808 nm) irradiation. Benefitting from ability, high against staphylococcus aureus through mechanically damaging destruction. This strategy biosafety effectiveness

Язык: Английский

Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment DOI
Shuyun Liu, Rui Xin, Xinyue Zhang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by thickening, severe pruritus, lesions, and emotional disturbances, including anxiety depression-like behavior. Current treatments primarily rely on localized therapies, which can lead to adverse effects such as hyperglycemia Cushing's syndrome with repeated use. To address these issues, we developed hyaluronic acid-based separable microneedle patch (Dic@pCu-HA MN), integrating polydopamine-coordinated copper-based metal-organic frameworks (pCu-MOFs) the anti-inflammatory agent dictamnine (Dic), for synergistic management of AD its neuropsychiatric comorbidities. pCu-MOFs exhibited dual functionality nanocargo hydrophobic Dic (encapsulation efficiency: 84.62 ± 2.14%) multienzyme mimics that efficiently scavenge reactive oxygen species (ROS) (superoxide radical scavenging: 63.85 0.34%). In vitro release studies demonstrated ROS-responsive 86.80 4.83% over 48 h under pathology-mimicking conditions. 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced mouse model, Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 7.8% decrease vs control), restored barrier integrity. By modulating HPA axis, system attenuated neuroinflammation alleviated itching (scratching frequency: 40.1 41.3% reduction) behavior (time in bright box: 96.6 156.2% increase). This combined therapeutic approach not only offers comprehensive strategy but also provides potential benefits addressing disorders their sequelae.

Язык: Английский

Процитировано

0

Bioinspired glycocalyx-mimetic hydrogel enabling photothermal-amplified therapeutic cascade for chronic wound healing DOI

Zongyan Quan,

Fangdie Ye,

Han Yu

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137669 - 137669

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects DOI Creative Commons
Zixuan Ou, Junyu Wei, Jie Lei

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 3, 2024

Critical-sized bone defects are usually accompanied by bacterial infection leading to inflammation and nonunion. However, existing biodegradable materials lack long-term therapeutical effect because of their gradual degradation. Here, a degradable material with continuous ROS modulation is proposed, defined as sonozyme due its functions sonosensitizer nanoenzyme. Before degradation, the can exert an effective sonodynamic antimicrobial through dual active sites MnN4 Cu2O8. Furthermore, it promote anti-inflammation superoxide dismutase- catalase-like activities. Following quercetin-metal chelation exhibits sustaining antioxidant ligand-metal charge transfer, while released ions quercetin also have great self-antimicrobial, osteogenic, angiogenic effects. A rat model infected cranial demonstrates rapidly eliminate bacteria regeneration. This work presents promising approach engineer long-time effects for infectious defects. Existing authors develop modulation, which eliminates promotes regeneration in

Язык: Английский

Процитировано

3

Metal-Phenolic Network Biointerface-mediated Cell Regulation for Bone Tissue Regeneration DOI Creative Commons

Ying Wang,

Zhi-Bang Li,

Ruiqing Yu

и другие.

Materials Today Bio, Год журнала: 2024, Номер 30, С. 101400 - 101400

Опубликована: Дек. 12, 2024

Язык: Английский

Процитировано

3

Versatile Ce(III)‐Terephthalic Acid@Au Metal Organic Frameworks for ROS Elimination and Photothermal Sterilization DOI
Jing Wang,

Xue Wei,

Jian Chen

и другие.

ChemNanoMat, Год журнала: 2024, Номер 10(7)

Опубликована: Апрель 16, 2024

Abstract Nanozymes have been widely used for treating reactive oxygen species (ROS) caused diseases. However, the ROS‐dependent antibacterial property is inevitably damaged during process of scavenging ROS, which unfavorable treatment diseases related to both ROS accumulation and bacterial infections. To address issues, biomedical materials with ROS‐elimination ability ROS‐independent capacity are fabricated via in situ depositing spherical Au nanoparticles (Au NPs) on rough surface metal organic frameworks composed Ce(III) terephthalic acid (Ce‐BDC@Au MOFs). The synthesized Ce‐BDC@Au MOFs show multi‐enzymatic activities owing reversible conversion between Ce 3+ 4+ , can significantly scavenge cells. deposition NPs Ce‐BDC causes come close proximity forming plasmon resonance coupling, inducing wavelength red shifted NIR region. Based this, good photothermal efficiency under laser (808 nm) irradiation. Benefitting from ability, high against staphylococcus aureus through mechanically damaging destruction. This strategy biosafety effectiveness

Язык: Английский

Процитировано

1