ChemNanoMat,
Journal Year:
2024,
Volume and Issue:
10(7)
Published: April 16, 2024
Abstract
Nanozymes
have
been
widely
used
for
treating
reactive
oxygen
species
(ROS)
caused
diseases.
However,
the
ROS‐dependent
antibacterial
property
is
inevitably
damaged
during
process
of
scavenging
ROS,
which
unfavorable
treatment
diseases
related
to
both
ROS
accumulation
and
bacterial
infections.
To
address
issues,
biomedical
materials
with
ROS‐elimination
ability
ROS‐independent
capacity
are
fabricated
via
in
situ
depositing
spherical
Au
nanoparticles
(Au
NPs)
on
rough
surface
metal
organic
frameworks
composed
Ce(III)
terephthalic
acid
(Ce‐BDC@Au
MOFs).
The
synthesized
Ce‐BDC@Au
MOFs
show
multi‐enzymatic
activities
owing
reversible
conversion
between
Ce
3+
4+
,
can
significantly
scavenge
cells.
deposition
NPs
Ce‐BDC
causes
come
close
proximity
forming
plasmon
resonance
coupling,
inducing
wavelength
red
shifted
NIR
region.
Based
this,
good
photothermal
efficiency
under
laser
(808
nm)
irradiation.
Benefitting
from
ability,
high
against
staphylococcus
aureus
through
mechanically
damaging
destruction.
This
strategy
biosafety
effectiveness
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disorder
marked
by
thickening,
severe
pruritus,
lesions,
and
emotional
disturbances,
including
anxiety
depression-like
behavior.
Current
treatments
primarily
rely
on
localized
therapies,
which
can
lead
to
adverse
effects
such
as
hyperglycemia
Cushing's
syndrome
with
repeated
use.
To
address
these
issues,
we
developed
hyaluronic
acid-based
separable
microneedle
patch
(Dic@pCu-HA
MN),
integrating
polydopamine-coordinated
copper-based
metal-organic
frameworks
(pCu-MOFs)
the
anti-inflammatory
agent
dictamnine
(Dic),
for
synergistic
management
of
AD
its
neuropsychiatric
comorbidities.
pCu-MOFs
exhibited
dual
functionality
nanocargo
hydrophobic
Dic
(encapsulation
efficiency:
84.62
±
2.14%)
multienzyme
mimics
that
efficiently
scavenge
reactive
oxygen
species
(ROS)
(superoxide
radical
scavenging:
63.85
0.34%).
In
vitro
release
studies
demonstrated
ROS-responsive
86.80
4.83%
over
48
h
under
pathology-mimicking
conditions.
1-Chloro-2,4-dinitrochlorobenzene
(DNCB)-induced
mouse
model,
Dic@pCu-HA
MN
significantly
reduced
oxidative
stress
(8-OHdG:
85.1
7.0%
decrease),
suppressed
pro-inflammatory
cytokines
(IL-4:
70.0
7.8%
decrease
vs
control),
restored
barrier
integrity.
By
modulating
HPA
axis,
system
attenuated
neuroinflammation
alleviated
itching
(scratching
frequency:
40.1
41.3%
reduction)
behavior
(time
in
bright
box:
96.6
156.2%
increase).
This
combined
therapeutic
approach
not
only
offers
comprehensive
strategy
but
also
provides
potential
benefits
addressing
disorders
their
sequelae.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 3, 2024
Critical-sized
bone
defects
are
usually
accompanied
by
bacterial
infection
leading
to
inflammation
and
nonunion.
However,
existing
biodegradable
materials
lack
long-term
therapeutical
effect
because
of
their
gradual
degradation.
Here,
a
degradable
material
with
continuous
ROS
modulation
is
proposed,
defined
as
sonozyme
due
its
functions
sonosensitizer
nanoenzyme.
Before
degradation,
the
can
exert
an
effective
sonodynamic
antimicrobial
through
dual
active
sites
MnN4
Cu2O8.
Furthermore,
it
promote
anti-inflammation
superoxide
dismutase-
catalase-like
activities.
Following
quercetin-metal
chelation
exhibits
sustaining
antioxidant
ligand-metal
charge
transfer,
while
released
ions
quercetin
also
have
great
self-antimicrobial,
osteogenic,
angiogenic
effects.
A
rat
model
infected
cranial
demonstrates
rapidly
eliminate
bacteria
regeneration.
This
work
presents
promising
approach
engineer
long-time
effects
for
infectious
defects.
Existing
authors
develop
modulation,
which
eliminates
promotes
regeneration
in
ChemNanoMat,
Journal Year:
2024,
Volume and Issue:
10(7)
Published: April 16, 2024
Abstract
Nanozymes
have
been
widely
used
for
treating
reactive
oxygen
species
(ROS)
caused
diseases.
However,
the
ROS‐dependent
antibacterial
property
is
inevitably
damaged
during
process
of
scavenging
ROS,
which
unfavorable
treatment
diseases
related
to
both
ROS
accumulation
and
bacterial
infections.
To
address
issues,
biomedical
materials
with
ROS‐elimination
ability
ROS‐independent
capacity
are
fabricated
via
in
situ
depositing
spherical
Au
nanoparticles
(Au
NPs)
on
rough
surface
metal
organic
frameworks
composed
Ce(III)
terephthalic
acid
(Ce‐BDC@Au
MOFs).
The
synthesized
Ce‐BDC@Au
MOFs
show
multi‐enzymatic
activities
owing
reversible
conversion
between
Ce
3+
4+
,
can
significantly
scavenge
cells.
deposition
NPs
Ce‐BDC
causes
come
close
proximity
forming
plasmon
resonance
coupling,
inducing
wavelength
red
shifted
NIR
region.
Based
this,
good
photothermal
efficiency
under
laser
(808
nm)
irradiation.
Benefitting
from
ability,
high
against
staphylococcus
aureus
through
mechanically
damaging
destruction.
This
strategy
biosafety
effectiveness
