Bioconjugate Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Currently,
pulmonary
complications
such
as
lung
infections
during
the
perioperative
period
are
still
main
cause
of
prolonged
hospitalization
and
death
in
patients
with
injury
due
to
lack
effective
drugs.
Clusterzyme,
a
kind
artificial
enzyme
high
enzyme-like
activity
safety
profile,
exhibits
good
effects
on
reducing
oxidative
stress
immunomodulation.
Here,
we
present
functionalized
patches
that
is
administered
airways
rescues
injured
organ
via
clusterzymes.
The
long-term
antioxidant
capacity
significantly
ameliorated
lipopolysaccharide-induced
function
impairment
significant
reduction
goblet
cell
metaplasia
stress.
inflammatory
factors
cytokines
interleukin-1β,
interleukin-6,
tumor
necrosis
factor-α
levels
decreased
by
50%,
while
mtDNA
copy
number
increased
50%
ATP
production
100%.
Mice
was
improved,
suggesting
can
rescue
modulating
immune
responses
well
protecting
mitochondria,
providing
an
avenue
for
intervention
injury.
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
The
clinical
treatment
of
central
nervous
system
(CNS)
injuries
presents
significant
challenges
due
to
the
inflammatory
microenvironment
(IME)
induced
by
CNS
injury,
which
inhibits
spontaneous
neuronal
regeneration.
Biomimetic
biomaterial‐based
IMEs
for
repair,
facilitate
reconstruction
neural
regeneration
circuits,
show
promise.
In
this
study,
development
novel
bioactive
peptide
nanofibers
(PNFs)/chitosan
(CS)/VD11
(VDELWPPWLPC)
hydrogels
(named
as
PCV)
is
reported,
created
reinforcing
composite
PNFs/CS
with
a
frog‐derived
neuroregenerative
(VD11).
exhibit
3D
porous
structure,
high
thermosensitivity,
good
injectability,
and
enhanced
neurotrophic
properties,
making
them
promising
candidates
repair.
in
vitro
tests
indicate
that
PCV
can
promote
proliferation,
migration,
differentiation
stem
cells
into
neurons,
well
guide
axonal
growth.
Additionally,
they
help
mitigate
responses
reducing
macrophage
activation
astrocyte
while
promoting
neovascularization.
vivo
animal
experimentsdemonstrate
enhance
blood
supply
damaged
area
migration
colonization
endogenous
support
Furthermore,
reduce
immune
limit
excessive
significantly
improving
motor
function
recovery
rats
spinal
cord
injuries.
these
findings,
it
suggested
provide
strategy
treating
regulating
IME.
Neural Regeneration Research,
Год журнала:
2025,
Номер
20(12), С. 3476 - 3500
Опубликована: Янв. 13, 2025
Enhancing
neurological
recovery
and
improving
the
prognosis
of
spinal
cord
injury
have
gained
research
attention
recently.
Spinal
is
associated
with
a
complex
molecular
cellular
microenvironment.
This
complexity
has
prompted
researchers
to
elucidate
underlying
pathophysiological
mechanisms
changes
identify
effective
treatment
strategies.
Traditional
approaches
for
repair
include
surgery,
oral
or
intravenous
medications,
administration
neurotrophic
factors;
however,
efficacy
these
remains
inconclusive,
serious
adverse
reactions
continue
be
concern.
With
advancements
in
tissue
engineering
regenerative
medicine,
emerging
strategies
now
involve
nanoparticle-based
nanodelivery
systems,
scaffolds,
functional
techniques
that
incorporate
biomaterials,
bioengineering,
stem
cell,
growth
factors
as
well
three-dimensional
bioprinting.
Ideal
biomaterial
scaffolds
should
not
only
provide
structural
support
neuron
migration,
adhesion,
proliferation,
differentiation
but
also
mimic
mechanical
properties
natural
tissue.
Additionally,
facilitate
axon
neurogenesis
by
offering
adjustable
topography
range
physical
biochemical
cues.
The
three-dimensionally
interconnected
porous
structure
appropriate
physicochemical
enabled
biomimetic
printing
technology
can
maximize
potential
biomaterials
used
treating
injury.
Therefore,
correct
selection
application
coupled
successful
clinical
translation,
represent
promising
objectives
enhance
review
elucidates
key
occurrence
regeneration
post-injury,
including
neuroinflammation,
oxidative
stress,
regeneration,
angiogenesis.
briefly
discusses
critical
role
systems
injured
cord,
highlighting
influence
nanoparticles
affect
delivery
efficiency.
Finally,
this
highlights
It
various
types
their
integrations
cells
factors,
optimization
scaffold
design.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Abstract
Remodeling
the
adaptive
microenvironment
with
biomaterials
presents
a
promising
avenue
for
addressing
chronic
inflammation
that
contributes
to
spinal
cord
injury
(SCI)
repair.
Hydrogels
have
been
widely
employed
enhance
tissue
regeneration
following
SCI.
Additionally,
zinc
(Zn)
ions
are
effective
in
immune
modulation
central
nervous
system.
However,
significant
challenges
remain
preparing
hydrogels
combining
bioactive
Zn
2+
biological
functionality
traumatic
SCI
In
this
study,
self‐healing
hydrogel
composed
of
an
alginate
network
based
on
dynamic
/bisphosphonate
(BP)
cross–linking,
and
silk
fibroin
interpenetrating
polymer
is
reported.
It
observed
neurite
outgrowth
promoted
by
shows
dependency
concentration.
Moreover,
‐releasing
enhances
neuronal
axon
growth
influences
neural
stem
cell
proliferation
differentiation.
addition,
regulates
microglial
fate
upregulating
anti‐inflammatory
signaling
molecule
A20
through
inhibition
NF‐κB
pathway.
Therefore,
effectively
improves
response
while
promoting
functional
recovery,
including
motor,
sensory,
bladder
function
completely
transected
These
results
indicate
/BP‐based
holds
potential
treatment.
Gels,
Год журнала:
2025,
Номер
11(4), С. 293 - 293
Опубликована: Апрель 15, 2025
As
an
intelligent
polymer
material,
pH-sensitive
hydrogels
exhibit
the
capability
to
dynamically
sense
alterations
in
ambient
pH
levels
and
subsequently
initiate
corresponding
physical
or
chemical
responses,
including
swelling,
contraction,
degradation,
ion
exchange.
Given
significant
variations
inherent
human
pathophysiological
microenvironments,
particularly
tumor
tissues,
inflammatory
lesions,
gastrointestinal
system,
these
smart
materials
demonstrate
remarkable
application
potential
across
diverse
domains
such
as
targeted
drug
delivery
systems,
regenerative
medicine
engineering,
biosensing,
disease
diagnostics.
Recent
breakthroughs
nanotechnology
precision
have
substantially
propelled
advancements
design
of
pH-responsive
hydrogels.
This
review
systematically
elaborates
on
current
research
progress
future
challenges
regarding
biomedical
applications,
with
particular
emphasis
their
stimulus–response
mechanisms,
fabrication
methodologies,
multifunctional
integration
strategies,
scenarios.
Spinal
cord
injury
(SCI)
is
a
severe
clinical
disease
usually
accompanied
by
activated
glial
scar,
neuronal
axon
rupture,
and
disabled
motor
function.
To
mimic
the
microenvironment
of
SCI
site,
hydrogel
system
with
comparable
mechanical
property
to
spinal
desirable.
Therefore,
novel
elastic
bovine
serum
albumin
(BSA)
fabricated
excellent
adhesive,
injectable,
biocompatible
properties.
The
used
deliver
paclitaxel
(PTX)
together
basic
fibroblast
growth
factor
(bFGF)
inhibit
scar
formation
as
well
promote
regeneration
function
for
repair.
Due
specific
interaction
BSA
both
drugs,
bFGF,
PTX
can
be
controllably
released
from
achieve
an
effective
concentration
at
wound
site
during
process.
Moreover,
benefiting
combination
this
bFGF/PTX@BSA
significantly
aided
repair
promoting
elongation
axons
across
reduced
reactive
astrocyte
secretion.
In
addition,
remarkable
anti-apoptosis
nerve
cells
evident
system.
Subsequently,
multi-functionalized
drug
improved
rats
after
SCI.
These
results
reveal
that
ideal
functionalized
material
in
