Nanoparticle-mediated immunogenic cell death for cancer immunotherapy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124045 - 124045

Опубликована: Март 30, 2024

Язык: Английский

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Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is great significance. Combinational modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against infections. Herein, red blood cell membrane fuses macrophage to develop hybrid shell, which further camouflages around drug-loaded liposome fabricate biomimetic (AB@LRM) precise therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) classical antibiotics amikacin (AM) are loaded in AB@LRM accurately target inflammatory sites through guidance long residence capability membrane, eventually exerting efficacious activities. Besides, due excellent photothermal photodynamic properties, BPQDs act as an efficient when exposed near-infrared laser irradiation, dramatically increasing sensitivity bacteria antibiotics. Consequently, synergistic sterilizing effect produced by restricts resistance. Upon shows superior anti-inflammatory properties models P. aeruginosa-infected pneumonia wounds. Hence, this light-activatable nanoplatform good biocompatibility presents advance clinical development

Язык: Английский

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Advances in and prospects of immunotherapy for prostate cancer

Cancer Letters, Год журнала: 2024, Номер 601, С. 217155 - 217155

Опубликована: Авг. 8, 2024

Immunotherapy has shown promising therapeutic effects in hematological malignancies and certain solid tumors emerged as a critical highly potential treatment modality for cancer. However, prostate cancer falls under the category of immune-resistant cold tumors, which immunotherapy exhibits limited efficacy patients with tumors. Thus, it is important to gain deeper understanding tumor microenvironment facilitate immune system activation overcome suppression advance In this review, we discuss immunosuppressive cancer, characterized by presence few tumor-infiltrating lymphocytes, abundant cells, low immunogenicity, noninflammatory phenotype, significantly influences mainly achieved activating host overcoming immunosuppression. regard, summarize advances checkpoint blockade, immunogenic cell death, reversal microenvironment, vaccines, adjuvants, chimeric antigen receptor T-cell therapy, penetration barriers aim providing novel research insights approaches enhance effectiveness

Язык: Английский

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Simple and Smart Metal–Phenolic Micelles for Optimizing Immunotherapy by Disrupting Tumor Stemness

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

cGAS-STING pathway activation has attracted considerable attention in antitumor immunotherapy, but clinical outcomes lag behind expectations due to overlooked negative feedback mechanisms. Here, we determine that STING promotes tumor stemness, which weakens the efficacy of STING-based therapies, presenting a double-edged sword. To address this therapeutic paradox, simple metal-phenolic polymeric micelle (HMQ) was developed, Mn2+ (a agonist) is coordinated with quercetin stemness inhibitor) and hyaluronic acid (HA), unlock full potential pathway. This unique coordination structure integrates active targeting rapid pH-responsive drug release. Importantly, released drugs remained their original form, avoiding changes bioactivity. HMQ effectively mitigates stemness-promoting effects activation, thus significantly amplifying potency cGAS-STING-based therapies. intelligent facile establishes new generation agonists promising translatability provides flexible platform for win–win strategy.

Язык: Английский

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One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor

Science Advances, Год журнала: 2025, Номер 11(5)

Опубликована: Янв. 29, 2025

Cancer immunotherapies rely on CD8 + cytolytic T lymphocytes (CTLs) in recognition and eradication of tumor cells via antigens presented major histocompatibility complex class I (MHC-I) molecules. However, we observe MHC-I deficiency human murine urologic tumors, posing daunting challenges for successful immunotherapy. We herein report an unprecedented nanosonosensitizer one-dimensional bamboo-like multisegmented manganese dioxide@manganese–bismuth vanadate (BMMBV) to boost multiple branches immune responses targeting MHC-I–deficient tumors. BMMBV markedly augments sonodynamic activity contributed by heteroatoms the lattice bismuth with narrowing bandgaps. Under sonoirradiation, enhances antigen spreading emission adjuvant signals, which potentiate dendritic cell maturation, thereby eliciting high aptitude CTLs. This therapy substantially up-regulates MHC expression cells, are reversely sensitive Alongside, extensive innate complement CTLs eliminating mouse study offers a reinforced strategy against antigen-loss immune-evasive tumor.

Язык: Английский

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DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28991 - 29002

Опубликована: Май 20, 2024

Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented of regulation TPP linkage modes remain challenges. Herein, we propose a free-radical-initiated random copolymerization in combination with hydrothermal carbonation regulate backbone for triphenylphosphine (TPPcopoly-CDs). The mechanism reactions is directional, straightforward, controllable. content IC50 hydroxyl radicals scavenging ability TPPcopoly-CDs are 53 wt % 0.52 mg/mL, respectively. serves as charge control agent elevate negatively charged CDs by 20 mV. negative can target mitochondria, corresponding moiety plays crucial role mitochondria. This discovery provides new perspective on controlled synthesis, modes, mitochondrial design TPP-CDs.

Язык: Английский

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Mito-Specific Nutri-Hijacker Synergizing Mitochondrial Metabolism and Glycolysis Intervention for Enhanced Antitumor Bioenergetic Therapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(23), С. 29902 - 29916

Опубликована: Май 29, 2024

Metabolic rewiring, a dynamic metabolic phenotype switch, confers that tumors exist and proliferate after fitness (or preadaptation) in harsh environmental conditions. Glycolysis deprivation was considered to be tumor's Achilles heel. However, configuration can flexibly retune the mitochondrial ability when glycolysis is scared, potentially resulting more aggressive clones. To address challenge of reprogramming, an antiglycolytic nanoparticle (GRPP NP) containing novel mitochondrial-targeted reactive oxygen species (ROS) generator (diIR780) prepared hijack glucose regulate mitochondria, thus completely eliminating tumorigenic energy sources. In this process, GRPP NPs@diIR780 catalyze endogenous glucose, leading significantly suppressed glycolysis. Moreover, diIR780 released selectively accumulated around mitochondria generate toxic ROS. These combined effects, turn, hamper metabolism pathways, which are crucial for driving tumor progression. This synchronous intervention strategy enables utter devastation providing promising regiment eradicate lesions without recurrence.

Язык: Английский

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A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(21), С. 19188 - 19199

Опубликована: Окт. 23, 2024

Mild mitochondrial uncoupling offers therapeutic benefits for various diseases like obesity by regulating cellular energy metabolism. However, effective chemical intervention tools inducing mild mitochondria-targeted are limited. Herein, we have developed a H2S prodrug M1 with unique property of on-demand photoactivated generation accompanied self-reporting fluorescence real-time tracking. Upon photoirradiation, decomposes in mitochondria to generate and turn-on fluorescent coumarin derivative the visualization quantification H2S. is confirmed induce reactive oxygen species (ROS)-dependent uncoupling, activating mitochondria-associated adenosine monophosphate-activated protein kinase (AMPK) suppress palmitic acid (PA)-induced lipid deposition hepatocytes. The functions induced strictly controlled mitochondria, representing fresh strategy prevent improve metabolic syndrome increasing expenditure.

Язык: Английский

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Targeting mitochondria in Cancer therapy: Machine learning analysis of hyaluronic acid-based drug delivery systems

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137840 - 137840

Опубликована: Ноя. 1, 2024

Язык: Английский

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