Platinum–Iron Nanoparticles for Oxygen-Enhanced Sonodynamic Tumor Cell Suppression

Inorganics, Год журнала: 2024, Номер 12(12), С. 331 - 331

Опубликована: Дек. 18, 2024

A type of nanoparticle has been developed to simultaneously alleviate tumor hypoxia and enhance the effectiveness sonodynamic therapy aimed at improving cancer treatment outcomes. Small-sized iron–platinum nanoparticles were prepared using a thermal reduction method, their particle size crystal structure characterized. The ability these decompose hydrogen peroxide produce oxygen generate singlet under ultrasound irradiation was further tested. effect on inhibition proliferation MCF-7 cells hypoxic conditions also evaluated. effectively decomposed oxygen, reversing environment tumors. Additionally, they generated irradiation, which killed inhibited proliferation. This study successfully small-sized that can by decomposing excess in oxygen. Under inhibiting growth. demonstrated good safety are potentially valuable enhancing oxygen-enhanced therapy.

Язык: Английский

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Construction of negative electrostatic sugared gourd pore within nickel-based metal-organic framework for one-step purification acetylene from ethylene and carbon dioxide mixture

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 154734 - 154734

Опубликована: Авг. 17, 2024

Язык: Английский

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Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics

Hybrid Advances, Год журнала: 2025, Номер unknown, С. 100406 - 100406

Опубликована: Фев. 1, 2025

Язык: Английский

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Exosomal ncRNAs in liquid biopsies for lung cancer

Clinica Chimica Acta, Год журнала: 2024, Номер 565, С. 119983 - 119983

Опубликована: Окт. 3, 2024

Язык: Английский

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Designing MOF-COF hybrid materials for energy, biomedical and environment applications

Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113262 - 113262

Опубликована: Окт. 1, 2024

Язык: Английский

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Biometallic ions and derivatives: a new direction for cancer immunotherapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Язык: Английский

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Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 678 - 695

Опубликована: Янв. 24, 2025

Язык: Английский

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Metal-organic frameworks for removing emerging organic pollutants: A review

Journal of Water Process Engineering, Год журнала: 2025, Номер 70, С. 107096 - 107096

Опубликована: Янв. 29, 2025

Язык: Английский

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Polyvalent Aptamer Nanodrug Conjugates Enable Efficient Tumor Cuproptosis Therapy Through Copper Overload and Glutathione Depletion

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(44), С. 30033 - 30045

Опубликована: Окт. 28, 2024

Cuproptosis, a recently identified form of copper-dependent cell death, shows promising tumor suppressive effects with minimal drug resistance. However, its therapeutic efficacy is hampered by dependence on copper ions and the glutathione (GSH)-rich microenvironment in tumors. Here, we have developed polyvalent aptamer nanodrug conjugates (termed CuPEs@PApt) nucleosome-like structure to improve cuproptosis therapy exploiting mitochondrial overload GSH depletion. Polyvalent (PApt), comprising epithelial adhesion molecule aptamers for targeting repetitive PolyT sequences chelation, facilitates efficient loading targeted delivery peroxide-Elesclomol nanodots (CuPEs). Upon internalization cells, Elesclomol released from CuPEs@PApt accumulates mitochondria initiate cuproptosis, while lysosomal degradation CuP generates exogenous Cu2+ H2O2, triggering Fenton-like reaction depletion enhance cuproptosis. In vitro vivo experiments confirm this strategy inducing immunogenic latter contributing activation antitumor immune response synergistic growth inhibition.

Язык: Английский

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Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, the tumor environment, dendritic often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function reduces ability to efficiently present antigens. Here, dual catalytic oxide nanosponge (DON) doubling as remotely boosted catalyst inducer of programming DCs program therapy is reported. Intravenous delivery DON enhances accumulation via marginated target. At site, incorporates cerium nanozyme (CeO

Язык: Английский

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