Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(7)

Опубликована: Янв. 4, 2021

Chemodynamic therapy (CDT) is an emerging method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of insufficient endogenous H2 and high concentration glutathione (GSH) in tumor cells, intelligent nanocatalytic theranostics (denoted as PGC-DOX) possesses both self-supply GSH-elimination properties for efficient presented. This nanoplatform constructed a facile one-step biomineralization using poly(ethylene glycol)-modified glucose oxidase (GOx) template to form biodegradable copper-doped calcium phosphate nanoparticles, followed loading doxorubicin (DOX). As enzyme catalyst, GOx can effectively catalyze generate , which not only starves but also supplies subsequent Fenton-like reaction. Meanwhile, redox reaction between released Cu2+ ions GSH will induce depletion reduce Fenton agent Cu+ ions, then trigger • OH -mediated reaction, resulting enhanced CDT efficacy. The integration GOx-mediated starvation therapy, CDT, DOX-induced chemotherapy, endow PGC-DOX with effective growth inhibition minimal side effects vivo.

Язык: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Год журнала: 2021, Номер 121(4), С. 1981 - 2019

Опубликована: Янв. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Язык: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Год журнала: 2021, Номер 18(6)

Опубликована: Ноя. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Язык: Английский

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Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

ACS Nano, Год журнала: 2019, Номер 13(12), С. 13985 - 13994

Опубликована: Дек. 13, 2019

Glucose oxidase (GOx) has been recognized as a "star" enzyme catalyst involved in cancer treatment the past few years. Herein, GOx is mineralized with manganese-doped calcium phosphate (MnCaP) to form spherical nanoparticles (GOx-MnCaP NPs) by an situ biomimetic mineralization method, followed loading of doxorubicin (DOX) construct biodegradable, biocompatible, and tumor acidity-responsive nanotheranostics for magnetic resonance imaging (MRI) cascade reaction-enhanced cooperative treatment. The GOx-driven oxidation reaction can effectively eliminate intratumoral glucose starvation therapy, elevated H2O2 then converted into highly toxic hydroxyl radicals via Mn2+-mediated Fenton-like chemodynamic therapy (CDT). Moreover, acidity amplification due gluconic acid generation will turn accelerate degradation nanoplatform promote Mn2+-H2O2 enhanced CDT. Meanwhile, released Mn2+ ions be used MRI monitor process. After carrying anticancer drug, DOX-loaded GOx-MnCaP integrate CDT, DOX-induced chemotherapy together, which showed greatly improved therapeutic efficacy than each monotherapy. Such orchestrated demonstrated high-efficiency suppression on 4T1 tumor-bearing mice minimal side effects. Our findings suggested that excellent biodegradability biocompatibility hold clinical translation potential management.

Язык: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Год журнала: 2021, Номер 33(48)

Опубликована: Сен. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Язык: Английский

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Mo₂C‐Derived Polyoxometalate for NIR‐II Photoacoustic Imaging‐Guided Chemodynamic/Photothermal Synergistic Therapy

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(51), С. 18641 - 18646

Опубликована: Окт. 12, 2019

To overcome the current limitations of chemodynamic therapy (CDT), a Mo2 C-derived polyoxometalate (POM) is readily synthesized as new CDT agent. It permits synergistic and photothermal operating in second near-infrared (NIR-II) biological transparent window for deep tissue penetration. POM aggregated an acidic tumor micro-environment (TME) whereby enables specific targeting. In addition to strong ability produce singlet oxygen (1 O2 ) presumably via Russell mechanism, its excellent conversion enhances effect, offers additional ablation modality, NIR-II photoacoustic imaging. Benefitting from reversible redox property molybdenum, theranostics based on can escape antioxidant defense system. Moreover, combining responsiveness TME localized laser irradiation, side-effects shall be largely avoided.

Язык: Английский

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Self‐Supply of O₂ and H₂O₂ by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy

Advanced Science, Год журнала: 2019, Номер 6(24)

Опубликована: Окт. 24, 2019

Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H

Язык: Английский

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Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy

Small, Год журнала: 2019, Номер 15(51)

Опубликована: Ноя. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Язык: Английский

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Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

Journal of the American Chemical Society, Год журнала: 2020, Номер 143(2), С. 538 - 559

Опубликована: Дек. 28, 2020

The past few decades have witnessed an evolution of nanomedicine from biologically inert entities to more smart systems, aimed at advancing in vivo functionality. However, we should recognize that most systems still rely on reasonable explanation-including some over-explanation-rather than definitive evidence, which is a watershed radically determining the speed and extent nanomedicine. Probing nano-bio interactions desirable functionality tissue, cellular, molecular levels frequently overlooked. Progress toward answering these questions will provide instructive insight guiding effective chemo-physical strategies. Thus, next generation, argue much effort be made evidence for proof-of-mechanism, lieu creating many new complicated similar proof-of-concept.

Язык: Английский

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