Abstract
This
study
presents
the
synthesis
and
characterization
of
a
new,
recyclable,
thermally
stable
heterogeneous
catalyst
for
efficient
polyhydroquinoline
chromene
derivatives.
The
was
characterized
using
various
techniques,
including
UV
spectroscopy,
FT‐IR,
TGA,
DTG,
SEM,
XRD,
ICP
Spectroscopy,
CHN
analysis.
successfully
designed
phthalocyanine
incorporates
both
Brønsted
Lewis
acid
functionality,
along
with
zwitterionic
properties.
It
effectively
utilized
in
methodology
offers
several
advantages,
such
as
simple
procedure,
excellent
yields,
short
reaction
time.
findings
from
this
research
provide
valuable
insights
into
formulating
advancing
new
catalysts
significant
organic
reactions.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Март 27, 2024
The
increasing
global
incidence
of
non-insulin-dependent
diabetes
mellitus
(NIDDM)
necessitates
innovative
therapeutic
solutions.
This
study
focuses
on
the
design,
synthesis
and
biological
evaluation
Schiff
base
derivatives
from
2-bromo-2-(2-chlorophenyl)
acetic
acid,
particularly
hydrazone
compounds
4a
4b.
Both
in-vitro
in-vivo
assays
demonstrate
these
derivatives'
strong
antidiabetic
anti-hyperlipidemic
properties.
In
a
15-d
experiment,
we
administered
4b
at
doses
2.5
5
mg/kg
body
weight,
which
effectively
improved
symptoms
alloxan-induced
in
mice.
These
included
weight
loss,
increased
water
consumption
high
blood
glucose
levels.
also
normalized
abnormal
levels
total
cholesterol
(TC),
triacylglycerol
(TG)
low-density
lipoprotein
(LDL-C),
while
raising
high-density
(HDLC).
Computational
analysis
showed
that
inhibited
α-glucosidase
enzyme
by
interacting
with
key
catalytic
residues,
specifically
Asp214
Asp349.
computational
results
were
confirmed
through
tests,
where
inhibitory
activity,
IC50
values
0.70
±
0.11
10.29
0.30
µM,
respectively.
more
effective
than
standard
drug,
acarbose,
had
an
value
873.34
1.67
µM.
Mechanistic
studies
further
indicated
competitive
inhibition,
reinforcing
potential
for
NIDDM
treatment.
Journal of Enzyme Inhibition and Medicinal Chemistry,
Год журнала:
2025,
Номер
40(1)
Опубликована: Фев. 6, 2025
Lespedeza
bicolour
Turcz.
is
a
traditional
medicinal
plant
with
wide
range
of
ethnomedicinal
values.
The
main
components
L.
essential
oil
(EO)
were
β-pinene
(15.41%),
β-phellandrene
(12.43%),
and
caryophyllene
(7.79%).
EO
showed
antioxidant
activity
against
ABTS
radical
DPPH
an
IC50
value
0.69
±
0.03
mg/mL
10.44
2.09
mg/mL,
respectively.
FRAP
was
81.96
6.17
μmol/g.
had
activities
acetylcholinesterase,
α-glucosidase,
β-lactamase
values
309.30
11.16
μg/mL,
360.47
35.67
27.54
1.21
Molecular
docking
methyl
dehydroabietate
docked
well
all
tested
enzymes.
Sclareol
(+)-borneol
acetate
the
strongest
binding
affinity
to
α-glucosidase
β-lactamase,
present
study
provides
direction
for
searching
enzyme
inhibitors
three
enzymes
shows
possesses
potential
treat
series
diseases.
