Alzheimer's
disease
(AD)
is
the
most
common
form
of
dementia
worldwide,
affecting
millions
people
around
globe.
AD
characterized
by
different
pathologies
being
beta-amyloid
(Aβ)
plaque
formation,
metal
ion
dysregulation,
and
oxidative
stress
(OS)
central
topics
under
investigation.
Copper-Aβ
complexes
have
been
shown
to
induce
catalytic
hydrogen
peroxide
formation
increase
OS
in
brain
leading
neuronal
death.
Pincer-type
compounds
are
tridentate
ligands
that
coordinate
metals
a
planar
fashion
whose
properties
can
be
tuned
via
group
substitutions,
giving
rise
many
possibilities
catalysis
drug
discovery.
In
this
work
we
evaluated
potential
pharmaceutical
activity
26
pincer
AD's
copper
ion-related
framework.
sense,
four
key
aspects
were
considered:
1)
Lipinski's
rule
five,
2)
blood-brain
barrier
permeation,
3)
standard
reduction
(SRP)
formed
complexes,
4)
ligand's
affinity
towards
cations.
The
evaluation
these
criteria
was
performed
means
bioinformatic
tools
electronic
structure
calculations
at
DFT
level
theory.
Our
results
suggest
two
from
set
antioxidant
agents,
whereas
five
them
promissory
distributor-like
context
AD.
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(2)
Опубликована: Фев. 18, 2025
Alzheimer’s
disease
(AD)
is
the
most
prevalent
cause
of
dementia
and
a
significant
contributor
to
health
issues
mortality
among
older
individuals.
This
condition
involves
progressive
deterioration
in
cognitive
function
onset
dementia.
Recent
advancements
suggest
that
development
AD
more
intricate
than
its
underlying
brain
abnormalities
alone.
In
addition,
disease,
metabolic
syndrome,
oxidative
stress
are
all
intricately
linked
one
another.
Increased
concentrations
circulating
lipids
disturbances
glucose
homeostasis
contribute
intensification
lipid
oxidation,
leading
gradual
depletion
body’s
antioxidant
defenses.
heightened
metabolism
adversely
impacts
cell
integrity,
resulting
neuronal
damage.
Pathways
commonly
acknowledged
as
contributors
pathogenesis
include
alterations
synaptic
plasticity,
disorganization
neurons,
death.
Abnormal
some
membrane
proteins
thought
creation
amyloid
(Aβ)
oligomers,
which
extremely
hazardous
neurotransmission
pathways,
especially
those
involving
acetylcholine.
The
interaction
between
Aβ
oligomers
these
neurotransmitter
systems
induce
cellular
dysfunction,
an
imbalance
signaling,
and,
ultimately,
manifestation
neurological
symptoms.
Antioxidants
have
impact
on
human
since
they
may
improve
aging
process
by
combating
free
radicals.
Neurodegenerative
diseases
currently
incurable;
however,
be
effectively
managed.
An
appealing
alternative
utilization
natural
antioxidants,
such
polyphenols,
through
diet
or
dietary
supplements,
offer
numerous
advantages.
Within
this
framework,
we
extensively
examined
importance
advancement
well
potential
influence
antioxidants
mitigating
effects.
Results in Engineering,
Год журнала:
2024,
Номер
22, С. 102216 - 102216
Опубликована: Май 3, 2024
This
study
investigated
the
suitability
of
moss
peat
and
compost
as
adsorbents
for
removing
copper
ions
from
aqueous
systems.
Kinetic
experiments
were
conducted
at
pH
4,
20
°C,
an
initial
ion
concentration
mM.
Under
these
experimental
conditions,
had
a
maximum
adsorption
capacity
45.8
41.9
mg/g,
respectively.
The
kinetic
data
was
assessed
using
several
models,
fitted
well
with
pseudo-second-order
model
both
adsorbents.
Moreover,
analysis
isotherm
showed
that
Langmuir
could
fit
data,
suggesting
are
chemically
adsorbed
onto
compost.
value
4.5
most
effective
At
this
value,
capacities
60.0
mg/g
56.9
characterization
before
after
interaction
indicated
surface
precipitation
dominant
mechanism
by
which
removed
Copper
on
higher
than
compost,
it
found
to
be
7.7
wt%
3.8
wt%,
Overall,
findings
highlight
potential
in
highly
contaminated
water,
particularly
industrial
mining
effluent.
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(2), С. 261 - 281
Опубликована: Май 25, 2024
A
big
problem
in
healthcare
around
the
world
is
neurological
illnesses.
There
a
huge
and
financial
burden
on
society
worldwide
due
to
dramatically
increased
risk
of
chronic
sickness
diseases
linked
with
posed
lifestyle
changes.
Fine
treatment
for
sick
illnesses
few
known
adverse
effects
goal
research.
number
functional
food
studies
have
been
launched
last
decades
an
effort
identify
meals
enhanced
therapeutic
activity
reduced
effects.
As
result,
research
into
nutraceutical
therapy
illness
prevention
various
extraction
procedures
disorders
has
underway.
Progressive
memory
loss
characterises
Alzheimer's
disease
(AD),
neurodegenerative
disorder.
The
pharmaceutical
options
available
today
are
expensive,
come
unwanted
side
effects,
short
supply.
Scientists
researchers
noticed
that
nutraceuticals
impact.
anti-Alzheimer's
efficacy
was
examined
clinical
preclinical
investigations.
study
new
targets,
such
as
pathophysiological
mechanisms
unique
cascades,
resulted
from
growing
understanding
AD
pathogenesis.
Therefore,
most
effective
well-known
will
be
showcased
present
development,
together
brief
involving
antioxidants,
autophagy
control,
anti-inflammatory,
mitochondrial
homeostasis,
more.
Nutraceuticals
real-world
impacts,
getting
your
hands
phytochemicals
other
vital
bioactive
ingredients
therapeutically
active
foods
top
priority.
Because
this,
term
"functional
foods"
muddied
replaced
similar
ones
"pharmafoods,"
"medifoods,"
"vita
foods,"
or
"medicinal
foods."
high
demand
counteract
interventions,
there
urgent
need
stick
healthy
options.
may
play
preventative
role
therapies
demonstrated
correlation
between
dietary
patterns
factors
neurodegeneration.
Examining
high-quality
trials
focus
study,
which
touches
several
important
topics.
In
light
nutraceuticals'
promise
multi-targeted
disease,
it
critical
assess
them
promising
lead
molecules
development
drugs.
Prospective
should,
according
authors'
understanding,
take
account
blood-brain
barrier
permeability
alteration,
bioavailability,
features
randomised
trials.
Journal of Coordination Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Янв. 3, 2025
The
4,5-diamine-2,6-dimercaptopyrimidine
(DAD)
molecule
contains
an
aromatic
N-heterocyclic
center
with
two
amino
and
thiol
groups,
providing
attractive
multifunctional
ligand
to
be
explored
in
coordination
chemistry
molecular
recognition
studies.
It
reacts
[Ru(bipy)2Cl2]
the
presence
of
air,
yielding
a
[Ru(bipy)2DAD]2+
complex,
which
converts
into
corresponding
Ru(II)-diimine
form,
leaving
pyrimidine
N-atoms
groups
available
for
participating
intermolecular
association
through
selective
hydrogen
bonding.
This
expectation
has
been
confirmed
by
resonance
Raman
spectroscopy
solution
solid
state
detailed
analysis
vibrational
peaks
Ru(II)-bipy
Ru(II)-DAD
chromophores
under
condition.
Accordingly,
it
was
observed
that
DAD
profiles
are
sensitive
interactions
species,
such
as
creatinine,
thus
expressing
typical
behavior.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(11), С. 1535 - 1535
Опубликована: Окт. 30, 2023
N-methyl-D-aspartate
receptors
(NMDARs)
are
ion
channels
that
respond
to
the
neurotransmitter
glutamate,
playing
a
crucial
role
in
permeability
of
calcium
ions
and
excitatory
neurotransmission
central
nervous
system
(CNS).
Composed
various
subunits,
NMDARs
predominantly
formed
by
two
obligatory
GluN1
subunits
(with
eight
splice
variants)
along
with
regulatory
GluN2
(GluN2A-2D)
GluN3
(GluN3A-B).
They
widely
distributed
throughout
CNS
involved
essential
functions
such
as
synaptic
transmission,
learning,
memory,
plasticity,
excitotoxicity.
The
presence
GluN2A
GluN2B
is
particularly
important
for
cognitive
processes
has
been
strongly
implicated
neurodegenerative
diseases
like
Parkinson’s
disease
Alzheimer’s
disease.
Understanding
roles
neuropathologies
provides
valuable
insights
into
underlying
causes
complexities
major
disorders.
This
knowledge
vital
development
selective
antagonists
targeting
using
pharmacological
molecular
methods.
Such
represent
promising
class
NMDA
receptor
inhibitors
have
potential
be
developed
neuroprotective
drugs
optimal
therapeutic
profiles.
