Pincer Ligands as Multifunctional Agents for Alzheimer's Copper Dysregulation and Oxidative Stress: A Computational Evaluation DOI
Nicolás Puentes‐Díaz, Diego Chaparro, David Morales‐Morales

et al.

ChemPlusChem, Journal Year: 2023, Volume and Issue: 88(12)

Published: Sept. 27, 2023

Alzheimer's disease (AD) is the most common form of dementia worldwide, affecting millions people around globe. AD characterized by different pathologies being beta-amyloid (Aβ) plaque formation, metal ion dysregulation, and oxidative stress (OS) central topics under investigation. Copper-Aβ complexes have been shown to induce catalytic hydrogen peroxide formation increase OS in brain leading neuronal death. Pincer-type compounds are tridentate ligands that coordinate metals a planar fashion whose properties can be tuned via group substitutions, giving rise many possibilities catalysis drug discovery. In this work we evaluated potential pharmaceutical activity 26 pincer AD's copper ion-related framework. sense, four key aspects were considered: 1) Lipinski's rule five, 2) blood-brain barrier permeation, 3) standard reduction (SRP) formed complexes, 4) ligand's affinity towards cations. The evaluation these criteria was performed means bioinformatic tools electronic structure calculations at DFT level theory. Our results suggest two from set antioxidant agents, whereas five them promissory distributor-like context AD.

Language: Английский

Injectable biocompatible RAFT mediated nitroxide nanogels: A robust ROS-reduction antioxidant approach DOI
Suman Basak, Ishita Mukherjee, Tushar Kanti Das

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 236, P. 113790 - 113790

Published: Feb. 7, 2024

Language: Английский

Citations

30
An overview on copper in industrial chemistry: From ancient pigment to modern catalysis DOI
Mohammad Soleiman‐Beigi, Masoud Mohammadi,

Homa Kohzadi

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216438 - 216438

Published: Jan. 17, 2025

Language: Английский

Citations

5
Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects DOI
Bushra Bashir, Monica Gulati, Sukriti Vishwas

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102689 - 102689

Published: Feb. 1, 2025

Language: Английский

Citations

3
The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease DOI Creative Commons
Rayees Ahmad Naik,

Mehak Naseer Mir,

Ishfaq Ahmad Malik

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 18, 2025

Alzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues mortality among older individuals. This condition involves progressive deterioration in cognitive function onset dementia. Recent advancements suggest that development AD more intricate than its underlying brain abnormalities alone. In addition, disease, metabolic syndrome, oxidative stress are all intricately linked one another. Increased concentrations circulating lipids disturbances glucose homeostasis contribute intensification lipid oxidation, leading gradual depletion body’s antioxidant defenses. heightened metabolism adversely impacts cell integrity, resulting neuronal damage. Pathways commonly acknowledged as contributors pathogenesis include alterations synaptic plasticity, disorganization neurons, death. Abnormal some membrane proteins thought creation amyloid (Aβ) oligomers, which extremely hazardous neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers these neurotransmitter systems induce cellular dysfunction, an imbalance signaling, and, ultimately, manifestation neurological symptoms. Antioxidants have impact on human since they may improve aging process by combating free radicals. Neurodegenerative diseases currently incurable; however, be effectively managed. An appealing alternative utilization natural antioxidants, such polyphenols, through diet or dietary supplements, offer numerous advantages. Within this framework, we extensively examined importance advancement well potential influence antioxidants mitigating effects.

Language: Английский

Citations

2
Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer’s Disease DOI

Raghuraj Singh,

Archna Panghal,

Krishna Jadhav

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10916 - 10940

Published: May 29, 2024

Language: Английский

Citations

12
Coordination chemistry and molecular recognition properties of a multifunctional-N-heterocyclic bis(bipyridine)ruthenium(II) complex DOI
Larissa K. A. da Silva, Hiago N. Silva, Marcelo Nakamura

et al.

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Jan. 3, 2025

The 4,5-diamine-2,6-dimercaptopyrimidine (DAD) molecule contains an aromatic N-heterocyclic center with two amino and thiol groups, providing attractive multifunctional ligand to be explored in coordination chemistry molecular recognition studies. It reacts [Ru(bipy)2Cl2] the presence of air, yielding a [Ru(bipy)2DAD]2+ complex, which converts into corresponding Ru(II)-diimine form, leaving pyrimidine N-atoms groups available for participating intermolecular association through selective hydrogen bonding. This expectation has been confirmed by resonance Raman spectroscopy solution solid state detailed analysis vibrational peaks Ru(II)-bipy Ru(II)-DAD chromophores under condition. Accordingly, it was observed that DAD profiles are sensitive interactions species, such as creatinine, thus expressing typical behavior.

Language: Английский

Citations

1
Utilization of organic-rich materials for the adsorption of copper ions from aqueous environments DOI Creative Commons
Suha T. Aldmour

Results in Engineering, Journal Year: 2024, Volume and Issue: 22, P. 102216 - 102216

Published: May 3, 2024

This study investigated the suitability of moss peat and compost as adsorbents for removing copper ions from aqueous systems. Kinetic experiments were conducted at pH 4, 20 °C, an initial ion concentration mM. Under these experimental conditions, had a maximum adsorption capacity 45.8 41.9 mg/g, respectively. The kinetic data was assessed using several models, fitted well with pseudo-second-order model both adsorbents. Moreover, analysis isotherm showed that Langmuir could fit data, suggesting are chemically adsorbed onto compost. value 4.5 most effective At this value, capacities 60.0 mg/g 56.9 characterization before after interaction indicated surface precipitation dominant mechanism by which removed Copper on higher than compost, it found to be 7.7 wt% 3.8 wt%, Overall, findings highlight potential in highly contaminated water, particularly industrial mining effluent.

Language: Английский

Citations

7
Therapeutic Approaches of Nutraceuticals in Neurological Disorders: A Review DOI Creative Commons

Vipul Kumar,

Harsh K. Gupta,

Anamika Anamika

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(2), P. 261 - 281

Published: May 25, 2024

A big problem in healthcare around the world is neurological illnesses. There a huge and financial burden on society worldwide due to dramatically increased risk of chronic sickness diseases linked with posed lifestyle changes. Fine treatment for sick illnesses few known adverse effects goal research. number functional food studies have been launched last decades an effort identify meals enhanced therapeutic activity reduced effects. As result, research into nutraceutical therapy illness prevention various extraction procedures disorders has underway. Progressive memory loss characterises Alzheimer's disease (AD), neurodegenerative disorder. The pharmaceutical options available today are expensive, come unwanted side effects, short supply. Scientists researchers noticed that nutraceuticals impact. anti-Alzheimer's efficacy was examined clinical preclinical investigations. study new targets, such as pathophysiological mechanisms unique cascades, resulted from growing understanding AD pathogenesis. Therefore, most effective well-known will be showcased present development, together brief involving antioxidants, autophagy control, anti-inflammatory, mitochondrial homeostasis, more. Nutraceuticals real-world impacts, getting your hands phytochemicals other vital bioactive ingredients therapeutically active foods top priority. Because this, term "functional foods" muddied replaced similar ones "pharmafoods," "medifoods," "vita foods," or "medicinal foods." high demand counteract interventions, there urgent need stick healthy options. may play preventative role therapies demonstrated correlation between dietary patterns factors neurodegeneration. Examining high-quality trials focus study, which touches several important topics. In light nutraceuticals' promise multi-targeted disease, it critical assess them promising lead molecules development drugs. Prospective should, according authors' understanding, take account blood-brain barrier permeability alteration, bioavailability, features randomised trials.

Language: Английский

Citations

7
GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases DOI Creative Commons

A. D. Ladagu,

Funmilayo Eniola Olopade, Adeboye Adejare

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1535 - 1535

Published: Oct. 30, 2023

N-methyl-D-aspartate receptors (NMDARs) are ion channels that respond to the neurotransmitter glutamate, playing a crucial role in permeability of calcium ions and excitatory neurotransmission central nervous system (CNS). Composed various subunits, NMDARs predominantly formed by two obligatory GluN1 subunits (with eight splice variants) along with regulatory GluN2 (GluN2A-2D) GluN3 (GluN3A-B). They widely distributed throughout CNS involved essential functions such as synaptic transmission, learning, memory, plasticity, excitotoxicity. The presence GluN2A GluN2B is particularly important for cognitive processes has been strongly implicated neurodegenerative diseases like Parkinson’s disease Alzheimer’s disease. Understanding roles neuropathologies provides valuable insights into underlying causes complexities major disorders. This knowledge vital development selective antagonists targeting using pharmacological molecular methods. Such represent promising class NMDA receptor inhibitors have potential be developed neuroprotective drugs optimal therapeutic profiles.

Language: Английский

Citations

16
Self-assembly of simple Schiff base ligand into unique saddle-type [4x4] tetranuclear architecture and its application as selective voltammetric dopamine sensor in aqueous conditions DOI Creative Commons
Daria Nowicka, Maciej Kubicki, Violetta Patroniak

et al.

Electrochimica Acta, Journal Year: 2024, Volume and Issue: 476, P. 143754 - 143754

Published: Jan. 1, 2024

Dopamine, a crucial catecholamine neurotransmitter, plays essential roles in the operation of central nervous system humans. Disrupted dopamine release is associated with neurological disorders and depression, therefore monitoring levels imperative for preliminary disease detection. Development sensitive selective sensors neurotransmitters that function under aqueous conditions however still challenging, mostly due to complexity hybrid nanomaterials are interacting electrode. Here we provide coordination compound constructed from simple substrates, where subcomponent self-assembly leads unique, discrete [4×4] saddle-type complex [Cu4(L-H)4(BF4)2(MeOH)2](BF4)2, which was characterized by ESI-MS FT-IR techniques, including single crystal X-ray diffraction. The Cu4L4 subsequently used modification bare Au electrode based on its accumulation surface. new voltammetric sensor (Au/complex) applied detection alone presence interfering ascorbic acid using Differential Pulse Voltammetry (DPV) techniques conditions. In linear dynamic range (LDR) 0.0001 mM 0.75 dependence peak current concentration satisfied following regression equation: ip [mA] = 17∙10−2 cDA [mM] + 8∙10−2 (R2 =0.998). Moreover, excellent limit (LOD) quantification (LOQ) were established at level 5.4 nM 18.0 accomplished high sensitivity 0.17 A M−1, repeatability as well reproducibility. Clear separation signal this one acid, even 100-fold excess ions found water, consequently proves prepared can be an analytical tool coexisting tested samples.

Language: Английский

Citations

6