Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Ноя. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
The
methodological
advancements
in
surface-enhanced
Raman
scattering
(SERS)
technique
with
nanoscale
materials
based
on
noble
metals,
Au,
Ag,
and
their
bimetallic
alloy
Au-Ag,
has
enabled
the
highly
efficient
sensing
of
chemical
biological
molecules
at
very
low
concentration
values.
By
employing
innovative
various
type
Ag
nanoparticles
especially,
high
efficiency
Au@Ag
nanomaterials
as
substrate
SERS
biosensors
have
revolutionized
detection
components
including;
proteins,
antigens
antibodies
complex,
circulating
tumor
cells,
DNA,
RNA
(miRNA),
etc.
This
review
is
about
SERS-based
Au/Ag
enhanced
activity
by
focusing
different
factors
related
to
them.
emphasis
this
research
describe
recent
developments
field
conceptual
behind
Furthermore,
article
we
apex
understanding
impact
variation
basic
features
like
effects
size,
shape
varying
lengths,
thickness
core-shell
influence
large-scale
magnitude
morphology.
Moreover,
detailed
information
applications
these
importantly
receptor
binding
domain
(RBD)
protein
COVID-19
provided.
Chemical Reviews,
Год журнала:
2023,
Номер
123(13), С. 8297 - 8346
Опубликована: Июнь 15, 2023
Omics
technologies
have
rapidly
evolved
with
the
unprecedented
potential
to
shape
precision
medicine.
Novel
omics
approaches
are
imperative
toallow
rapid
and
accurate
data
collection
integration
clinical
information
enable
a
new
era
of
healthcare.
In
this
comprehensive
review,
we
highlight
utility
Raman
spectroscopy
(RS)
as
an
emerging
technology
for
clinically
relevant
applications
using
significant
samples
models.
We
discuss
use
RS
both
label-free
approach
probing
intrinsic
metabolites
biological
materials,
labeled
where
signal
from
reporters
conjugated
nanoparticles
(NPs)
serve
indirect
measure
tracking
protein
biomarkers
Abstract
Infectious
diseases
caused
by
microbial
pathogens
remain
a
primary
contributor
to
global
health
burdens.
Prompt
control
and
effective
prevention
of
these
are
critical
for
public
medical
diagnostics.
Conventional
detection
methods
suffer
from
high
complexity,
low
sensitivity,
poor
selectivity.
Therefore,
developing
rapid
reliable
pathogen
has
become
imperative.
Surface‐enhanced
Raman
Spectroscopy
(SERS),
as
an
innovative
non‐invasive
diagnostic
technique,
holds
significant
promise
in
pathogenic
microorganism
due
its
rapid,
reliable,
cost‐effective
advantages.
This
review
comprehensively
outlines
the
fundamental
theories
(RS)
with
focus
on
label‐free
SERS
strategy,
reporting
latest
advancements
technique
detecting
bacteria,
viruses,
fungi
clinical
settings.
Furthermore,
we
emphasize
application
machine
learning
algorithms
spectral
analysis.
Finally,
challenges
faced
probed,
prospective
development
is
discussed.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(10), С. 5118 - 5148
Опубликована: Янв. 1, 2024
3D
cancer
models
recapitulate
the
tumor
microenvironment
and
serve
as
a
platform
to
study
cell
behavior,
drug
discovery
early
diagnosis,
which
can
be
monitored
chemically
with
subcellular
resolution
in
real
time,
via
SERS.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
The
year
2024
marks
the
50th
anniversary
of
discovery
surface-enhanced
Raman
spectroscopy
(SERS).
Over
recent
years,
SERS
has
experienced
rapid
development
and
became
a
critical
tool
in
biomedicine
with
its
unparalleled
sensitivity
molecular
specificity.
This
review
summarizes
advancements
challenges
substrates,
nanotags,
instrumentation,
spectral
analysis
for
biomedical
applications.
We
highlight
key
developments
colloidal
solid
an
emphasis
on
surface
chemistry,
hotspot
design,
3D
hydrogel
plasmonic
architectures.
Additionally,
we
introduce
innovations
including
those
interior
gaps,
orthogonal
reporters,
near-infrared-II-responsive
properties,
along
biomimetic
coatings.
Emerging
technologies
such
as
optical
tweezers,
nanopores,
wearable
sensors
have
expanded
capabilities
single-cell
single-molecule
analysis.
Advances
analysis,
signal
digitalization,
denoising,
deep
learning
algorithms,
improved
quantification
complex
biological
data.
Finally,
this
discusses
applications
nucleic
acid
detection,
protein
characterization,
metabolite
monitoring,
vivo
spectroscopy,
emphasizing
potential
liquid
biopsy,
metabolic
phenotyping,
extracellular
vesicle
diagnostics.
concludes
perspective
clinical
translation
SERS,
addressing
commercialization
potentials
tissue
sensing
imaging.
ACS Nano,
Год журнала:
2022,
Номер
16(7), С. 10341 - 10353
Опубликована: Июнь 8, 2022
Profiling
the
heterogeneous
landscape
of
cell
types
and
biomolecules
is
rapidly
being
adopted
to
address
current
imperative
research
questions.
Precision
medicine
seeks
advancements
in
molecular
spatial
profiling
techniques
with
highly
multiplexed
imaging
capabilities
subcellular
resolution,
which
remains
an
extremely
complex
task.
Surface-enhanced
Raman
spectroscopy
(SERS)
offers
promise
through
utilization
nanoparticle-based
contrast
agents
that
exhibit
narrow
spectral
features
specificity.
The
renaissance
gold
nanoparticle
technology
makes
scattering
intensities
competitive
traditional
fluorescence
methods
while
offering
added
benefit
unsurpassed
multiplexing
capabilities.
Here,
we
present
expanded
library
individually
distinct
SERS
nanoparticles
arm
researchers
clinicians.
Our
consist
a
∼60
nm
core,
reporter
molecule,
final
inert
silica
coating.
Using
density
functional
theory,
have
selected
reporters
meet
key
criterion
high
uniqueness
facilitate
unmixing
up
26
components
single
pixel
vitro
vivo.
We
also
demonstrated
utility
our
for
targeting
cultured
cells
cancerous
human
tissue
sections
optical
imaging.
This
study
showcases
far-reaching
SERS-based
improve
personalized
overcome
major
challenges
structural
diversity
proteomic
ACS Applied Nano Materials,
Год журнала:
2022,
Номер
5(9), С. 12276 - 12299
Опубликована: Авг. 22, 2022
Surface-Enhanced
Raman
Spectroscopy
(SERS)
is
a
powerful
analytical
technique
for
the
detection
of
small
analytes
with
great
potential
medical
diagnostic
applications.
Its
high
sensitivity
and
excellent
molecular
specificity,
which
stems
from
unique
fingerprint
species,
have
been
applied
toward
different
types
cancer.
The
noninvasive
rapid
offered
by
SERS
highlights
its
applicability
point-of-care
(PoC)
deployment
cancer
diagnosis,
screening,
staging,
as
well
predicting
tumor
recurrence
treatment
monitoring.
This
review
provides
an
overview
progress
in
label-free
(direct)
SERS-based
chemical
diagnosis
main
focus
on
advances
design
preparation
substrates
basis
metal
nanoparticle
structures
formed
via
bottom-up
strategies.
It
begins
introducing
synopsis
working
principles
SERS,
including
key
chemometric
approaches
spectroscopic
data
analysis.
Then
it
introduces
sensing
using
biofluids
(blood,
urine,
saliva,
sweat)
breath
media.
In
end,
outlook
challenges
provided.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(9), С. 3577 - 3599
Опубликована: Авг. 17, 2023
Nanozymes
are
nanoparticles
with
intrinsic
enzyme-mimicking
properties
that
have
become
more
prevalent
because
of
their
ability
to
outperform
conventional
enzymes
by
overcoming
drawbacks
related
stability,
cost,
and
storage.
the
potential
manipulate
active
sites
natural
enzymes,
which
is
why
they
considered
promising
candidates
function
as
enzyme
mimetics.
Several
microscopy-
spectroscopy-based
techniques
been
used
for
characterization
nanozymes.
To
date,
a
wide
range
nanozymes,
including
catalase,
oxidase,
peroxidase,
superoxide
dismutase,
designed
effectively
mimic
enzymes.
The
activity
nanozymes
can
be
controlled
regulating
structural
morphological
aspects
multifaceted
benefits,
exploited
on
large
scale
application
in
biomedical
sector.
versatility
aids
monitoring
treating
cancer,
other
neurodegenerative
diseases,
metabolic
disorders.
Due
compelling
advantages
significant
research
advancements
made
this
area.
Although
act
potent
mimetics
specificities
suboptimal,
there
still
room
diversification
analytical
purposes.
Designing
diverse
nanozyme
systems
sensitive
one
or
substrates
through
specialized
has
subject
an
in-depth
study.
Hence,
we
believe
stimuli-responsive
may
open
avenues
diagnosis
treatment
fusing
catalytic
nanomaterial
systems.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 6947 - 6947
Опубликована: Апрель 8, 2023
The
review
briefly
describes
various
types
of
infrared
(IR)
and
Raman
spectroscopy
methods.
At
the
beginning
review,
basic
concepts
biological
methods
environmental
monitoring,
namely
bioanalytical
biomonitoring
methods,
are
considered.
main
part
principles
vibration
microspectrophotometry,
in
particular
IR
spectroscopy,
mid-
near-IR
microspectroscopy,
resonance
Surface-enhanced
microscopy.
Examples
use
for
study
samples,
especially
context
given.
Based
on
described
results,
authors
conclude
that
spectroscopy-based
most
convenient
studies,
relevance
monitoring
will
increase
with
time.
