Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications DOI Creative Commons
Priyanka Singh, Santosh Pandit, Sri Renukadevi Balusamy

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Nov. 6, 2024

Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.

Language: Английский

Recent advances of Au@Ag core–shell SERS‐based biosensors DOI Creative Commons

Gul Awiaz,

Jie Lin, Aiguo Wu

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 1, 2023

The methodological advancements in surface-enhanced Raman scattering (SERS) technique with nanoscale materials based on noble metals, Au, Ag, and their bimetallic alloy Au-Ag, has enabled the highly efficient sensing of chemical biological molecules at very low concentration values. By employing innovative various type Ag nanoparticles especially, high efficiency Au@Ag nanomaterials as substrate SERS biosensors have revolutionized detection components including; proteins, antigens antibodies complex, circulating tumor cells, DNA, RNA (miRNA), etc. This review is about SERS-based Au/Ag enhanced activity by focusing different factors related to them. emphasis this research describe recent developments field conceptual behind Furthermore, article we apex understanding impact variation basic features like effects size, shape varying lengths, thickness core-shell influence large-scale magnitude morphology. Moreover, detailed information applications these importantly receptor binding domain (RBD) protein COVID-19 provided.

Language: Английский

Citations

85
The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine DOI
Gabriel Cutshaw, Saji Uthaman, Nora Hassan

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(13), P. 8297 - 8346

Published: June 15, 2023

Omics technologies have rapidly evolved with the unprecedented potential to shape precision medicine. Novel omics approaches are imperative toallow rapid and accurate data collection integration clinical information enable a new era of healthcare. In this comprehensive review, we highlight utility Raman spectroscopy (RS) as an emerging technology for clinically relevant applications using significant samples models. We discuss use RS both label-free approach probing intrinsic metabolites biological materials, labeled where signal from reporters conjugated nanoparticles (NPs) serve indirect measure tracking protein biomarkers

Language: Английский

Citations

73
Label‐free surface‐enhanced Raman spectroscopy coupled with machine learning algorithms in pathogenic microbial identification: Current trends, challenges, and perspectives DOI Creative Commons
Jia‐Wei Tang, Quan Yuan,

Xin‐Ru Wen

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3)

Published: March 5, 2024

Abstract Infectious diseases caused by microbial pathogens remain a primary contributor to global health burdens. Prompt control and effective prevention of these are critical for public medical diagnostics. Conventional detection methods suffer from high complexity, low sensitivity, poor selectivity. Therefore, developing rapid reliable pathogen has become imperative. Surface‐enhanced Raman Spectroscopy (SERS), as an innovative non‐invasive diagnostic technique, holds significant promise in pathogenic microorganism due its rapid, reliable, cost‐effective advantages. This review comprehensively outlines the fundamental theories (RS) with focus on label‐free SERS strategy, reporting latest advancements technique detecting bacteria, viruses, fungi clinical settings. Furthermore, we emphasize application machine learning algorithms spectral analysis. Finally, challenges faced probed, prospective development is discussed.

Language: Английский

Citations

19
SERS in 3D cell models: a powerful tool in cancer research DOI Creative Commons
Lara Troncoso-Afonso, Gail A. Vinnacombe‐Willson, Clara García‐Astrain

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(10), P. 5118 - 5148

Published: Jan. 1, 2024

3D cancer models recapitulate the tumor microenvironment and serve as a platform to study cell behavior, drug discovery early diagnosis, which can be monitored chemically with subcellular resolution in real time, via SERS.

Language: Английский

Citations

17
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges DOI Creative Commons
Li Lin, Ramón A. Álvarez‐Puebla, Luis M. Liz‐Marzán

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Language: Английский

Citations

3
FOXO3a in cancer drug resistance DOI
Ying Liu, Yu Wang, Xiaoge Li

et al.

Cancer Letters, Journal Year: 2022, Volume and Issue: 540, P. 215724 - 215724

Published: May 8, 2022

Language: Английский

Citations

54
Expanding the Multiplexing Capabilities of Raman Imaging to Reveal Highly Specific Molecular Expression and Enable Spatial Profiling DOI
Olga E. Eremina, Alexander Czaja,

Augusta Fernando

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 10341 - 10353

Published: June 8, 2022

Profiling the heterogeneous landscape of cell types and biomolecules is rapidly being adopted to address current imperative research questions. Precision medicine seeks advancements in molecular spatial profiling techniques with highly multiplexed imaging capabilities subcellular resolution, which remains an extremely complex task. Surface-enhanced Raman spectroscopy (SERS) offers promise through utilization nanoparticle-based contrast agents that exhibit narrow spectral features specificity. The renaissance gold nanoparticle technology makes scattering intensities competitive traditional fluorescence methods while offering added benefit unsurpassed multiplexing capabilities. Here, we present expanded library individually distinct SERS nanoparticles arm researchers clinicians. Our consist a ∼60 nm core, reporter molecule, final inert silica coating. Using density functional theory, have selected reporters meet key criterion high uniqueness facilitate unmixing up 26 components single pixel vitro vivo. We also demonstrated utility our for targeting cultured cells cancerous human tissue sections optical imaging. This study showcases far-reaching SERS-based improve personalized overcome major challenges structural diversity proteomic

Language: Английский

Citations

54
Label-Free Sensing with Metal Nanostructure-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis DOI Creative Commons
Marios Constantinou, Katerina Hadjigeorgiou, Sara Abalde‐Cela

et al.

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(9), P. 12276 - 12299

Published: Aug. 22, 2022

Surface-Enhanced Raman Spectroscopy (SERS) is a powerful analytical technique for the detection of small analytes with great potential medical diagnostic applications. Its high sensitivity and excellent molecular specificity, which stems from unique fingerprint species, have been applied toward different types cancer. The noninvasive rapid offered by SERS highlights its applicability point-of-care (PoC) deployment cancer diagnosis, screening, staging, as well predicting tumor recurrence treatment monitoring. This review provides an overview progress in label-free (direct) SERS-based chemical diagnosis main focus on advances design preparation substrates basis metal nanoparticle structures formed via bottom-up strategies. It begins introducing synopsis working principles SERS, including key chemometric approaches spectroscopic data analysis. Then it introduces sensing using biofluids (blood, urine, saliva, sweat) breath media. In end, outlook challenges provided.

Language: Английский

Citations

39
Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications DOI
Swati Singh, Nilesh Rai, Harshita Tiwari

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(9), P. 3577 - 3599

Published: Aug. 17, 2023

Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming drawbacks related stability, cost, and storage. the potential manipulate active sites natural enzymes, which is why they considered promising candidates function as enzyme mimetics. Several microscopy- spectroscopy-based techniques been used for characterization nanozymes. To date, a wide range nanozymes, including catalase, oxidase, peroxidase, superoxide dismutase, designed effectively mimic enzymes. The activity nanozymes can be controlled regulating structural morphological aspects multifaceted benefits, exploited on large scale application in biomedical sector. versatility aids monitoring treating cancer, other neurodegenerative diseases, metabolic disorders. Due compelling advantages significant research advancements made this area. Although act potent mimetics specificities suboptimal, there still room diversification analytical purposes. Designing diverse nanozyme systems sensitive one or substrates through specialized has subject an in-depth study. Hence, we believe stimuli-responsive may open avenues diagnosis treatment fusing catalytic nanomaterial systems.

Language: Английский

Citations

38
Vibrational Spectroscopy as a Tool for Bioanalytical and Biomonitoring Studies DOI Open Access
S. K. Pirutin, Shunchao Jia, A. I. Yusipovich

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6947 - 6947

Published: April 8, 2023

The review briefly describes various types of infrared (IR) and Raman spectroscopy methods. At the beginning review, basic concepts biological methods environmental monitoring, namely bioanalytical biomonitoring methods, are considered. main part principles vibration microspectrophotometry, in particular IR spectroscopy, mid- near-IR microspectroscopy, resonance Surface-enhanced microscopy. Examples use for study samples, especially context given. Based on described results, authors conclude that spectroscopy-based most convenient studies, relevance monitoring will increase with time.

Language: Английский

Citations

26