Advanced Materials Technologies,
Год журнала:
2022,
Номер
7(9)
Опубликована: Март 14, 2022
Abstract
The
traditional
way
of
disease
diagnosis
is
to
detect
biomarkers
in
serum,
blood,
urine,
and
saliva,
but
it
often
faces
wound
infection
pain,
usually
requires
professional
medical
personnel
operate,
which
unacceptable
for
most
people.
As
a
result,
minimally
invasive
detection
has
attracted
wide
attention
expected
become
new
method
patient
monitoring
diagnosis.
Interstitial
fluid
(ISF)
acts
as
medium
between
cells
the
circulatory
system,
serving
reservoir
biomolecules,
nutrients,
metabolic
products.
Microneedles
(MNs)
are
effective
carriers
delivering
drugs,
vaccines,
stem
cells.
What's
more,
MNs
provide
painless,
simple,
collect
skin
ISF.
In
summary,
structural
functional
characteristics
incomparable
advantages
open
door
future
monitoring.
techniques
invasive,
convenient,
compliant
individualized
long‐term
treatments,
up
areas
this
review,
various
ISF
sampling
reviewed,
their
challenges
development
prospects
discussed.
ACS Sensors,
Год журнала:
2022,
Номер
8(1), С. 158 - 166
Опубликована: Дек. 7, 2022
Microneedle
sensor
technology
offers
exciting
opportunities
for
decentralized
clinical
analyses.
A
novel
issue
puts
forward
herein
is
to
demonstrate
the
uniqueness
of
membrane-based
microneedles
accomplish
real-time,
on-body
monitoring
multiple
ions
simultaneously.
The
use
multi-ion
detection
clinically
relevant
since
it
expected
provide
a
more
complete
and
reliable
assessment
status
subject
concerning
electrolyte
disorders
others.
We
present
microneedle
system
transdermal
multiplexed
tracing
pH,
Na+,
K+,
Ca2+,
Li+,
Cl–.
device
consists
an
array
seven
solid
externally
modified
six
indicator
electrodes,
each
selective
different
ion,
common
reference
electrode,
all
integrated
into
wearable
patch
read
in
potentiometric
mode.
show
vitro
measurements
at
levels,
resulting
fast
response
time,
excellent
reversibility
repeatability,
adequate
selectivity.
Close-to-Nernstian
sensitivity,
sufficient
stability
resiliency
skin
penetration
guarantee
sensor's
success
measurements,
which
we
through
ex
vivo
(with
pieces
rat
skin)
(on-body
rats)
tests.
Accuracy
evaluated
by
comparison
with
gold
standard
techniques
characterize
collected
dermal
fluid,
blood,
serum.
In
past,
interstitial
fluid
(ISF)
analysis
has
been
challenging
due
difficult
sample
collection
analysis.
For
ions,
this
resulted
extrapolations
from
blood
concentrations
(invasive
tests)
rather
than
pure
ISF.
developed
analytical
tool
address
information
gap.
Biosensors and Bioelectronics,
Год журнала:
2023,
Номер
236, С. 115408 - 115408
Опубликована: Май 16, 2023
Microneedle
sensors
could
enable
minimally-invasive,
continuous
molecular
monitoring
-
informing
on
disease
status
and
treatment
in
real-time.
Wearable
for
pharmaceuticals,
example,
would
create
opportunities
treatments
personalized
to
individual
pharmacokinetics.
Here,
we
demonstrate
a
commercial-off-the-shelf
(COTS)
approach
microneedle
sensing
using
an
electrochemical
aptamer-based
sensor
that
detects
the
high-toxicity
antibiotic,
vancomycin.
of
vancomycin
improve
patient
care
by
allowing
targeted
drug
dosing
within
its
narrow
clinical
window
safety
efficacy.
To
produce
sensors,
miniaturize
microelectrode
format,
embed
them
stainless
steel
microneedles
(sourced
from
commercial
insulin
pen
needles).
The
achieve
quantitative
measurements
body-temperature
undiluted
blood.
Further,
effectively
maintain
signal
porcine
skin.
This
COTS
requires
no
cleanroom
fabrication
or
specialized
equipment,
produces
individually-addressable,
sterilizable
capable
easily
penetrating
In
future,
this
be
adapted
multiplexed
detection,
enabling
real-time
range
biomarkers.
Microneedles
(MNs)
have
drawn
rising
attention
owing
to
their
merits
of
convenience,
noninvasiveness,
flexible
applicability,
painless
microchannels
with
boosted
metabolism,
and
precisely
tailored
multifunction
control.
MNs
can
be
modified
serve
as
novel
transdermal
drug
delivery,
which
conventionally
confront
the
penetration
barrier
caused
by
skin
stratum
corneum.
The
micrometer-sized
needles
create
channels
through
corneum,
enabling
efficient
delivery
dermis
for
gratifying
efficacy.
Then,
incorporating
photosensitizer
or
photothermal
agents
into
conduct
photodynamic
therapy,
respectively.
Besides,
health
monitoring
medical
detection
MN
sensors
extract
information
from
interstitial
fluid
other
biochemical/electronic
signals.
Here,
this
review
discloses
a
monitoring,
diagnostic,
therapeutic
pattern
MNs,
elaborate
discussion
about
classified
formation
together
various
applications
inherent
mechanism.
Hereby,
development
outlook
biomedical/nanotechnology/photoelectric/devices/informatics
multidisciplinary
are
provided.
Programmable
intelligent
enable
logic
encoding
diverse
treatment
pathways
signals,
optimize
therapy
efficacy,
real-time
remote
control,
screening,
take
instant
treatment.
Biosensors,
Год журнала:
2023,
Номер
13(8), С. 823 - 823
Опубликована: Авг. 15, 2023
Hydrogel-based
wearable
electrochemical
biosensors
(HWEBs)
are
emerging
biomedical
devices
that
have
recently
received
immense
interest.
The
exceptional
properties
of
HWEBs
include
excellent
biocompatibility
with
hydrophilic
nature,
high
porosity,
tailorable
permeability,
the
capability
reliable
and
accurate
detection
disease
biomarkers,
suitable
device–human
interface,
facile
adjustability,
stimuli
responsive
to
nanofiller
materials.
Although
biomimetic
three-dimensional
hydrogels
can
immobilize
bioreceptors,
such
as
enzymes
aptamers,
without
any
loss
in
their
activities.
However,
most
suffer
from
low
mechanical
strength
electrical
conductivity.
Many
studies
been
performed
on
electroactive
nanofillers,
including
biomacromolecules,
carbon-based
materials,
inorganic
organic
nanomaterials,
tackle
these
issues.
Non-conductive
even
conductive
may
be
modified
by
well
redox
species.
All
modifications
led
design
development
efficient
nanocomposites
biosensors.
In
this
review,
both
conductive-based
non-conductive-based
derived
natural
synthetic
polymers
systematically
reviewed.
main
synthesis
methods
characterization
techniques
addressed.
behavior
discussed
detail.
Finally,
prospects
potential
applications
biosensing,
healthcare
monitoring,
clinical
diagnostics
highlighted.
Biomaterials Science,
Год журнала:
2023,
Номер
12(3), С. 530 - 563
Опубликована: Ноя. 7, 2023
Wearable
devices
have
become
prevalent
in
biomedical
studies
due
to
their
convenient
portability
and
potential
utility
biomarker
monitoring
for
healthcare.
Accessing
interstitial
fluid
(ISF)
across
the
skin
barrier,
microneedle
(MN)
is
a
promising
minimally
invasive
wearable
technology
transdermal
sensing
drug
delivery.
MN
has
overcome
limitations
of
conventional
administration,
making
it
another
prospective
mode
delivery
after
oral
injectable.
Subsequently,
combining
with
multiple
approaches
led
its
extensive
application
detect
biomarkers
ISF.
In
this
context,
employing
platforms
control
schemes
merge
diagnostic
therapeutic
capabilities
into
theranostic
systems
will
facilitate
on-demand
therapy
point-of-care
diagnostics,
paving
way
future
technologies.
A
comprehensive
analysis
growing
advances
microneedles
presented
review
summarize
latest
academics
field
offer
reference
issues
that
need
be
addressed
Covering
an
array
novel
studies,
we
discuss
following
main
topics:
classification
field,
considerations
design,
current
applications
diagnosis
therapy,
regulatory
landscape
prospects
applications.
This
sheds
light
on
significance
microneedle-based
innovations,
presenting
implications
contributions
community
healthcare
The
provides
understanding
field's
state
potential,
valuable
resource
clinicians
seeking
harness
full
Abstract
Microneedles
(MNs)
have
maintained
their
popularity
in
therapeutic
and
diagnostic
medical
applications
throughout
the
past
decade.
MNs
are
originally
designed
to
gently
puncture
stratum
corneum
layer
of
skin
lately
evolved
into
intelligent
devices
with
functions
including
bodily
fluid
extraction,
biosensing,
drug
administration.
offer
limited
invasiveness,
ease
application,
minimal
discomfort.
Initially
manufactured
solely
from
metals,
now
available
polymer‐based
varieties.
can
be
used
create
systems
that
deliver
drugs
chemicals
uniformly,
collect
fluids,
stimulus‐sensitive.
Although
these
advancements
favorable
terms
biocompatibility
production
costs,
they
insufficient
for
use
MNs.
This
is
first
comprehensive
review
discusses
individual
MN
toward
evolution
development
smart
multifunctional
a
variety
novel
impactful
future
applications.
The
study
examines
fabrication
techniques,
application
purposes,
experimental
details
constructs
perform
multiple
concurrently,
sensing,
drug‐molecule
release,
sampling,
remote
communication
capabilities.
It
highly
likely
near
future,
MN‐based
will
useful
important
component
standard
practice
different
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(3), С. 1682 - 1693
Опубликована: Фев. 9, 2024
Microneedle-based
drug
delivery
offers
an
attractive
and
minimally
invasive
administration
route
to
deliver
therapeutic
agents
through
the
skin
by
bypassing
stratum
corneum,
main
barrier.
Recently,
hydrogel-based
microneedles
have
gained
prominence
for
their
exceptional
ability
precisely
control
release
of
cargo.
In
this
study,
we
investigated
feasibility
fabricating
from
triblock
amphiphiles
with
linear
poly(ethylene
glycol)
(PEG)
as
hydrophilic
middle
block
two
dendritic
side-blocks
enzyme-cleavable
hydrophobic
end-groups.
Due
poor
formation
brittleness
made
neat
amphiphile,
added
a
sodium
alginate
base
layer
tested
different
polymeric
excipients
enhance
mechanical
strength
microneedles.
Following
optimization,
based
on
were
successfully
fabricated
exhibited
favorable
insertion
efficiency
low
height
reduction
percentage
when
in
Parafilm
skin-simulant
model.
When
against
static
forces
ranging
50
1000
g
(4.9–98
mN/needle),
showed
adequate
no
fractures
or
broken
segments.
buffer
solution,
solid
swelled
into
hydrogel
within
about
30
s,
followed
rapid
disintegration
small
particles.
These
particles
could
undergo
slow
enzymatic
degradation
soluble
polymers.
vitro
study
dexamethasone
(DEX),
steroid
model
drug,
first-order
release,
90%
released
6
days.
Eventually,
DEX-loaded
MNs
subjected
test
using
chicken
full
penetration.
This
demonstrates
programming
hydrogel-forming
several
mesophase
transitions
potential
application
system
self-administration,
increased
patient
compliance,
improved
efficacy,
sustained
release.
