Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences,
Год журнала:
2024,
Номер
480(2304)
Опубликована: Дек. 1, 2024
This
study
systematically
investigates,
both
analytically
and
numerically,
transdermal
drug
delivery
using
a
microneedle
(MN)
array.
The
released
from
the
MN
tip
disperses
through
viable
skin
before
being
absorbed
in
blood
compartment.
Reversible
uptake
kinetics
between
tissue
compartments,
together
with
reversible
specific
binding
of
its
receptors
tissue,
have
been
taken
into
account.
governing
equations
are
solved
numerically
an
explicit
manner.
Simulations
predict
that
metabolism
skin,
irreversible
stabilizing
effect
on
free
bound
verapamil
concentrations.
In
addition,
longer
larger
skin–blood
interface
area
contribute
to
higher
concentrations
all
forms
compartments.
results
suggest
lack
compartment
might
overestimate
verapamil.
A
thorough
sensitivity
analysis
has
performed
account
for
uncertainties
some
parameters
involved.
retention
relationship
length
MN,
time
application,
interface,
rate
compartments
constitute
novel
aspect
this
analytical
numerical
work.
Our
reduced
model
is
excellent
agreement
available
literature.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(9), С. 1439 - 1454
Опубликована: Апрель 8, 2024
Microneedles
offer
minimally
invasive,
user-friendly,
and
subcutaneously
accessible
transdermal
drug
delivery
have
been
widely
investigated
as
an
effective
system.
Ibuprofen
is
a
common
anti-inflammatory
to
treat
chronic
inflammation.
It
crucial
develop
microneedle
patches
capable
of
efficiently
delivering
ibuprofen
through
the
skin
for
treatment
arthritis
patients
requiring
repeated
medication.
In
this
study,
mechanical
properties
new
type
polymer
were
studied
by
finite
element
analysis,
experimental
results
showed
that
could
effectively
deliver
drugs
skin.
addition,
high
ibuprofen-loaded
patch
was
successfully
prepared
micromolding
subjected
evaluation
its
infrared
spectrum
morphology
dissolve
degree.
The
microneedles
characterized
scanning
electron
microscopy,
assessed
using
built
linear
stretching
in-vitro
diffusion
cell
release
test,
released
85.2
±
1.52%
(210
3.7
μg)
in
modified
Franz
within
4
h,
exhibiting
higher
compared
other
methods.
This
study
provides
portable,
safe
efficient
approach
daily
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Abstract
Transdermal
healthcare
systems
have
gained
significant
attention
for
their
painless
and
convenient
drug
administration,
as
well
ability
to
detect
biomarkers
promptly.
However,
the
skin
barrier
limits
candidates
of
biomolecules
that
can
be
transported,
reliance
on
simple
diffusion
poses
a
bottleneck
personalized
diagnosis
treatment.
Consequently,
recent
advancements
in
transdermal
transport
technologies
evolved
toward
active
methods
based
external
energy
sources.
Multiple
combinations
these
also
shown
promise
increasing
therapeutic
effectiveness
diagnostic
accuracy
delivery
efficiency
is
maximized.
Furthermore,
wearable
platforms
are
being
developed
diverse
aspects
patient
convenience,
safety,
on‐demand
Herein,
comprehensive
overview
provided,
highlighting
combination‐based
diagnostics,
therapeutics,
theragnostics,
along
with
latest
trends
platform
advancements.
This
offers
insights
into
potential
applications
next‐generation
medical
devices
autonomous
healthcare.
