Advanced Materials Technologies,
Год журнала:
2022,
Номер
7(9)
Опубликована: Март 14, 2022
Abstract
The
traditional
way
of
disease
diagnosis
is
to
detect
biomarkers
in
serum,
blood,
urine,
and
saliva,
but
it
often
faces
wound
infection
pain,
usually
requires
professional
medical
personnel
operate,
which
unacceptable
for
most
people.
As
a
result,
minimally
invasive
detection
has
attracted
wide
attention
expected
become
new
method
patient
monitoring
diagnosis.
Interstitial
fluid
(ISF)
acts
as
medium
between
cells
the
circulatory
system,
serving
reservoir
biomolecules,
nutrients,
metabolic
products.
Microneedles
(MNs)
are
effective
carriers
delivering
drugs,
vaccines,
stem
cells.
What's
more,
MNs
provide
painless,
simple,
collect
skin
ISF.
In
summary,
structural
functional
characteristics
incomparable
advantages
open
door
future
monitoring.
techniques
invasive,
convenient,
compliant
individualized
long‐term
treatments,
up
areas
this
review,
various
ISF
sampling
reviewed,
their
challenges
development
prospects
discussed.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(9), С. 13279 - 13301
Опубликована: Фев. 19, 2025
The
advancements
in
wearable
sensor
technology
have
revolutionized
noninvasive
body
fluid
monitoring,
offering
new
possibilities
for
continuous
and
real-time
health
assessment.
By
analyzing
fluids
such
as
sweat,
saliva,
tears,
interstitial
fluid,
these
technologies
provide
painless
diagnostic
alternatives
detecting
biomarkers
glucose,
electrolytes,
metabolites.
These
sensors
play
a
crucial
role
early
disease
detection,
chronic
condition
management,
personalized
healthcare.
Recent
innovations
flexible
electronics,
microfluidic
systems,
biosensing
materials
significantly
improved
the
accuracy,
reliability,
integration
of
into
everyday
textiles.
Moreover,
convergence
artificial
intelligence
big
data
analytics
has
enhanced
precision
personalization
monitoring
transforming
powerful
tools
holographic
inspection.
Despite
significant
progress,
challenges
remain,
including
improving
stability
dynamic
environments,
achieving
transmission,
covering
broader
range
biomarkers.
Future
research
directions
focus
on
enhancing
material
sustainability
through
green
synthesis,
optimizing
sampling
techniques,
leveraging
machine
learning
to
further
improve
performance.
This
Review
highlights
transformative
potential
medical
applications,
aiming
bridge
gaps
healthcare
accessibility
elevate
standards
patient
care
technologies.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Abstract
Driven
by
the
growing
burden
of
chronic
diseases
and
limited
public
healthcare
resources,
portable
health
monitoring
platforms
are
widely
developed
to
enable
continuous
timely
dissemination
provide
users
with
management
disease
prevention.
However,
it
is
still
a
challenge
for
precision
fully
bio‐integrated
electronic
devices
achieve
stable
physiological
signal
recording
over
long
periods
time.
Recently,
semi‐implantable
bioelectronics
(SI‐bioelectronics)
have
excelled
in
real‐time,
long‐term,
high‐sensitivity
pathological
signals
minimal
invasiveness,
enabled
precise
microneedle
sensing
probes.
In
this
review,
comprehensive
overview
recent
advancements
SI‐bioelectronics
provided,
focus
on
their
structures,
design
considerations,
performances
biochemical
indicators,
bioelectrical
signals,
biomechanical
signals.
Opportunities
research
such
as
smart
medicine
Internet
Things
also
discussed,
which
will
drive
toward
intelligence
efficiency.
Advanced Materials Technologies,
Год журнала:
2022,
Номер
7(9)
Опубликована: Март 14, 2022
Abstract
The
traditional
way
of
disease
diagnosis
is
to
detect
biomarkers
in
serum,
blood,
urine,
and
saliva,
but
it
often
faces
wound
infection
pain,
usually
requires
professional
medical
personnel
operate,
which
unacceptable
for
most
people.
As
a
result,
minimally
invasive
detection
has
attracted
wide
attention
expected
become
new
method
patient
monitoring
diagnosis.
Interstitial
fluid
(ISF)
acts
as
medium
between
cells
the
circulatory
system,
serving
reservoir
biomolecules,
nutrients,
metabolic
products.
Microneedles
(MNs)
are
effective
carriers
delivering
drugs,
vaccines,
stem
cells.
What's
more,
MNs
provide
painless,
simple,
collect
skin
ISF.
In
summary,
structural
functional
characteristics
incomparable
advantages
open
door
future
monitoring.
techniques
invasive,
convenient,
compliant
individualized
long‐term
treatments,
up
areas
this
review,
various
ISF
sampling
reviewed,
their
challenges
development
prospects
discussed.
