Microneedle‐Based Technology: Toward Minimally Invasive Disease Diagnostics DOI
Na Xu, Wenxin Xu,

Manyue Zhang

и другие.

Advanced Materials Technologies, Год журнала: 2022, Номер 7(9)

Опубликована: Март 14, 2022

Abstract The traditional way of disease diagnosis is to detect biomarkers in serum, blood, urine, and saliva, but it often faces wound infection pain, usually requires professional medical personnel operate, which unacceptable for most people. As a result, minimally invasive detection has attracted wide attention expected become new method patient monitoring diagnosis. Interstitial fluid (ISF) acts as medium between cells the circulatory system, serving reservoir biomolecules, nutrients, metabolic products. Microneedles (MNs) are effective carriers delivering drugs, vaccines, stem cells. What's more, MNs provide painless, simple, collect skin ISF. In summary, structural functional characteristics incomparable advantages open door future monitoring. techniques invasive, convenient, compliant individualized long‐term treatments, up areas this review, various ISF sampling reviewed, their challenges development prospects discussed.

Язык: Английский

Tailoring Design of Microneedles for Drug Delivery and Biosensing DOI

Yuexi Lin,

Muamer Dervisevic, Hao Zhe Yoh

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.

Язык: Английский

Процитировано

2

Smart Wearable Sensor Fuels Noninvasive Body Fluid Analysis DOI
Kang Wang, Wenjing Liu,

Jingzhi Wu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(9), С. 13279 - 13301

Опубликована: Фев. 19, 2025

The advancements in wearable sensor technology have revolutionized noninvasive body fluid monitoring, offering new possibilities for continuous and real-time health assessment. By analyzing fluids such as sweat, saliva, tears, interstitial fluid, these technologies provide painless diagnostic alternatives detecting biomarkers glucose, electrolytes, metabolites. These sensors play a crucial role early disease detection, chronic condition management, personalized healthcare. Recent innovations flexible electronics, microfluidic systems, biosensing materials significantly improved the accuracy, reliability, integration of into everyday textiles. Moreover, convergence artificial intelligence big data analytics has enhanced precision personalization monitoring transforming powerful tools holographic inspection. Despite significant progress, challenges remain, including improving stability dynamic environments, achieving transmission, covering broader range biomarkers. Future research directions focus on enhancing material sustainability through green synthesis, optimizing sampling techniques, leveraging machine learning to further improve performance. This Review highlights transformative potential medical applications, aiming bridge gaps healthcare accessibility elevate standards patient care technologies.

Язык: Английский

Процитировано

1

Recent Progress in Semi‐Implantable Bioelectronics for Precision Health Monitoring DOI

Wenting Chen,

Xinyu Zheng, Zhou Yue

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Driven by the growing burden of chronic diseases and limited public healthcare resources, portable health monitoring platforms are widely developed to enable continuous timely dissemination provide users with management disease prevention. However, it is still a challenge for precision fully bio‐integrated electronic devices achieve stable physiological signal recording over long periods time. Recently, semi‐implantable bioelectronics (SI‐bioelectronics) have excelled in real‐time, long‐term, high‐sensitivity pathological signals minimal invasiveness, enabled precise microneedle sensing probes. In this review, comprehensive overview recent advancements SI‐bioelectronics provided, focus on their structures, design considerations, performances biochemical indicators, bioelectrical signals, biomechanical signals. Opportunities research such as smart medicine Internet Things also discussed, which will drive toward intelligence efficiency.

Язык: Английский

Процитировано

1

Highly sensing and transducing materials for potentiometric ion sensors with versatile applicability DOI

Mei‐Rong Huang,

Xin‐Gui Li

Progress in Materials Science, Год журнала: 2021, Номер 125, С. 100885 - 100885

Опубликована: Окт. 22, 2021

Язык: Английский

Процитировано

56

Microneedle‐Based Technology: Toward Minimally Invasive Disease Diagnostics DOI
Na Xu, Wenxin Xu,

Manyue Zhang

и другие.

Advanced Materials Technologies, Год журнала: 2022, Номер 7(9)

Опубликована: Март 14, 2022

Abstract The traditional way of disease diagnosis is to detect biomarkers in serum, blood, urine, and saliva, but it often faces wound infection pain, usually requires professional medical personnel operate, which unacceptable for most people. As a result, minimally invasive detection has attracted wide attention expected become new method patient monitoring diagnosis. Interstitial fluid (ISF) acts as medium between cells the circulatory system, serving reservoir biomolecules, nutrients, metabolic products. Microneedles (MNs) are effective carriers delivering drugs, vaccines, stem cells. What's more, MNs provide painless, simple, collect skin ISF. In summary, structural functional characteristics incomparable advantages open door future monitoring. techniques invasive, convenient, compliant individualized long‐term treatments, up areas this review, various ISF sampling reviewed, their challenges development prospects discussed.

Язык: Английский

Процитировано

38