Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
12(3), P. 530 - 563
Published: Nov. 7, 2023
Wearable
devices
have
become
prevalent
in
biomedical
studies
due
to
their
convenient
portability
and
potential
utility
biomarker
monitoring
for
healthcare.
Accessing
interstitial
fluid
(ISF)
across
the
skin
barrier,
microneedle
(MN)
is
a
promising
minimally
invasive
wearable
technology
transdermal
sensing
drug
delivery.
MN
has
overcome
limitations
of
conventional
administration,
making
it
another
prospective
mode
delivery
after
oral
injectable.
Subsequently,
combining
with
multiple
approaches
led
its
extensive
application
detect
biomarkers
ISF.
In
this
context,
employing
platforms
control
schemes
merge
diagnostic
therapeutic
capabilities
into
theranostic
systems
will
facilitate
on-demand
therapy
point-of-care
diagnostics,
paving
way
future
technologies.
A
comprehensive
analysis
growing
advances
microneedles
presented
review
summarize
latest
academics
field
offer
reference
issues
that
need
be
addressed
Covering
an
array
novel
studies,
we
discuss
following
main
topics:
classification
field,
considerations
design,
current
applications
diagnosis
therapy,
regulatory
landscape
prospects
applications.
This
sheds
light
on
significance
microneedle-based
innovations,
presenting
implications
contributions
community
healthcare
The
provides
understanding
field's
state
potential,
valuable
resource
clinicians
seeking
harness
full
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(17)
Published: Feb. 11, 2024
Abstract
Wearable
epidermal
electronics
with
non‐
or
minimally‐invasive
characteristics
can
collect,
transduce,
communicate,
and
interact
accessible
physicochemical
health
indicators
on
the
skin.
However,
due
to
stratum
corneum
layer,
rich
information
about
body
is
buried
under
skin
for
example,
in
interstitial
fluid.
Microneedle
patches
are
typically
designed
arrays
of
special
microsized
needles
length
within
1000
µm.
Such
potentially
enable
access
sample
biomolecules
give
therapeutical
treatment
painlessly
transdermally.
Integrating
microneedle
various
allows
highly
efficient
transdermal
bioelectronics,
showing
their
great
promise
biomedical
healthcare
applications.
This
comprehensive
review
summarizes
highlights
recent
progress
integrated
bioelectronics
based
patches.
The
design
criteria
state‐of‐the‐art
fabrication
techniques
such
devices
initially
discussed.
Next,
different
functions,
including
but
not
limited
monitoring,
drug
delivery,
treatment,
highlighted
detail.
Finally,
key
issues
associated
current
technologies
future
opportunities
elaborated
sort
out
state
research,
point
potential
bottlenecks,
provide
research
directions.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Abstract
Driven
by
the
growing
burden
of
chronic
diseases
and
limited
public
healthcare
resources,
portable
health
monitoring
platforms
are
widely
developed
to
enable
continuous
timely
dissemination
provide
users
with
management
disease
prevention.
However,
it
is
still
a
challenge
for
precision
fully
bio‐integrated
electronic
devices
achieve
stable
physiological
signal
recording
over
long
periods
time.
Recently,
semi‐implantable
bioelectronics
(SI‐bioelectronics)
have
excelled
in
real‐time,
long‐term,
high‐sensitivity
pathological
signals
minimal
invasiveness,
enabled
precise
microneedle
sensing
probes.
In
this
review,
comprehensive
overview
recent
advancements
SI‐bioelectronics
provided,
focus
on
their
structures,
design
considerations,
performances
biochemical
indicators,
bioelectrical
signals,
biomechanical
signals.
Opportunities
research
such
as
smart
medicine
Internet
Things
also
discussed,
which
will
drive
toward
intelligence
efficiency.
Advanced Materials Technologies,
Journal Year:
2022,
Volume and Issue:
7(9)
Published: March 14, 2022
Abstract
The
traditional
way
of
disease
diagnosis
is
to
detect
biomarkers
in
serum,
blood,
urine,
and
saliva,
but
it
often
faces
wound
infection
pain,
usually
requires
professional
medical
personnel
operate,
which
unacceptable
for
most
people.
As
a
result,
minimally
invasive
detection
has
attracted
wide
attention
expected
become
new
method
patient
monitoring
diagnosis.
Interstitial
fluid
(ISF)
acts
as
medium
between
cells
the
circulatory
system,
serving
reservoir
biomolecules,
nutrients,
metabolic
products.
Microneedles
(MNs)
are
effective
carriers
delivering
drugs,
vaccines,
stem
cells.
What's
more,
MNs
provide
painless,
simple,
collect
skin
ISF.
In
summary,
structural
functional
characteristics
incomparable
advantages
open
door
future
monitoring.
techniques
invasive,
convenient,
compliant
individualized
long‐term
treatments,
up
areas
this
review,
various
ISF
sampling
reviewed,
their
challenges
development
prospects
discussed.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
12(3), P. 530 - 563
Published: Nov. 7, 2023
Wearable
devices
have
become
prevalent
in
biomedical
studies
due
to
their
convenient
portability
and
potential
utility
biomarker
monitoring
for
healthcare.
Accessing
interstitial
fluid
(ISF)
across
the
skin
barrier,
microneedle
(MN)
is
a
promising
minimally
invasive
wearable
technology
transdermal
sensing
drug
delivery.
MN
has
overcome
limitations
of
conventional
administration,
making
it
another
prospective
mode
delivery
after
oral
injectable.
Subsequently,
combining
with
multiple
approaches
led
its
extensive
application
detect
biomarkers
ISF.
In
this
context,
employing
platforms
control
schemes
merge
diagnostic
therapeutic
capabilities
into
theranostic
systems
will
facilitate
on-demand
therapy
point-of-care
diagnostics,
paving
way
future
technologies.
A
comprehensive
analysis
growing
advances
microneedles
presented
review
summarize
latest
academics
field
offer
reference
issues
that
need
be
addressed
Covering
an
array
novel
studies,
we
discuss
following
main
topics:
classification
field,
considerations
design,
current
applications
diagnosis
therapy,
regulatory
landscape
prospects
applications.
This
sheds
light
on
significance
microneedle-based
innovations,
presenting
implications
contributions
community
healthcare
The
provides
understanding
field's
state
potential,
valuable
resource
clinicians
seeking
harness
full
