The Analyst, Год журнала: 2024, Номер 150(2), С. 378 - 385
Опубликована: Дек. 3, 2024
A dual gas donor of nitric oxide and hydrogen sulfide is employed for photocontrolled release in cells can be utilized to investigate the synergistic effect two gases on inflammation cells.
Язык: Английский
ACS Bio & Med Chem Au, Год журнала: 2025, Номер 5(1), С. 175 - 183
Опубликована: Янв. 3, 2025
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that regulates various physiological functions, and its abnormal levels have been closely linked to the onset progression of numerous diseases including renal cell carcinoma (RCC). RCC most common malignant tumor kidney, accounting for 85-90% all kidney cancer cases. However, studies using H2S as a biomarker monitoring at molecular level remain relatively limited. Most current luminescent probes suffer from low sensitivity often need external stimuli, such cysteine, artificially elevate levels, thereby reducing their effectiveness in detecting cells or vivo. Although bioluminescent imaging are gaining attention specificity high signal-to-noise ratio, no existing specifically designed RCC. Additionally, many face challenges short emission wavelengths dependence on complex conditions adenosine triphosphate (ATP). Herein, through "caging" luciferin substrate QTZ with recognition groups, H2S-sensitive probe QTZ-N3 good (∼0.19 μM) selectivity was prepared. can effectively detect 786-O-Nluc sensitively monitor xenograft nude mouse model without requiring stimuli like cysteine. Furthermore, allows real-time during progression. This work lays solid foundation future understanding biological functions
Язык: Английский
Процитировано
1
JACS Au, Год журнала: 2024, Номер 4(7), С. 2687 - 2694
Опубликована: Июль 5, 2024
Hydrogen sulfide (H2S) is a gaseous signaling molecule, exerting crucial regulatory functions in organelles and cellular environments. H2S exhibits high therapeutic potential synergistic effects with other drugs, its potency notably enhanced through organelle-specific targeting. Yet, the navigation of light-activated donors to specific remains absent. Here, we report first photocage that simultaneously delivers payload subcellular precision mitochondria live human cells using tissue-penetrating near-infrared light as trigger. The fluorogenic enables real-time monitoring process, demonstrate concurrent uncaging combination fluorescence microscopy mitochondria-specific fluorescent probes. We anticipate these photocages will permit precise delivery H2S-drug combinations exceptional spatiotemporal control, thereby driving harnessing known discovery novel strategies.
Язык: Английский
Процитировано
4
Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
A comprehensive overview of recent advancements in fluorescence imaging techniques for situ sensing various biomarkers, emphasizing the transformative potential artificial intelligence shaping future bioimaging.
Язык: Английский
Процитировано
4
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157086 - 157086
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1
The Analyst, Год журнала: 2024, Номер 150(2), С. 378 - 385
Опубликована: Дек. 3, 2024
A dual gas donor of nitric oxide and hydrogen sulfide is employed for photocontrolled release in cells can be utilized to investigate the synergistic effect two gases on inflammation cells.
Язык: Английский
Процитировано
0