A Photo-triggered Dual-gas Donor of Nitric Oxide and Hydrogen Sulfide with Fluorescence to Real-time Monitor Its Release DOI
Anfu Hou,

Zhenmei Lin,

Yongfang Cheng

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 150(2), P. 378 - 385

Published: Dec. 3, 2024

A dual gas donor of nitric oxide and hydrogen sulfide is employed for photocontrolled release in cells can be utilized to investigate the synergistic effect two gases on inflammation cells.

Language: Английский

A Bioluminescent Probe for H2S Detection in Tumor Microenvironment DOI Creative Commons
Lu Kang, Yixian Wang, Chenhang Wang

et al.

ACS Bio & Med Chem Au, Journal Year: 2025, Volume and Issue: 5(1), P. 175 - 183

Published: Jan. 3, 2025

Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that regulates various physiological functions, and its abnormal levels have been closely linked to the onset progression of numerous diseases including renal cell carcinoma (RCC). RCC most common malignant tumor kidney, accounting for 85-90% all kidney cancer cases. However, studies using H2S as a biomarker monitoring at molecular level remain relatively limited. Most current luminescent probes suffer from low sensitivity often need external stimuli, such cysteine, artificially elevate levels, thereby reducing their effectiveness in detecting cells or vivo. Although bioluminescent imaging are gaining attention specificity high signal-to-noise ratio, no existing specifically designed RCC. Additionally, many face challenges short emission wavelengths dependence on complex conditions adenosine triphosphate (ATP). Herein, through "caging" luciferin substrate QTZ with recognition groups, H2S-sensitive probe QTZ-N3 good (∼0.19 μM) selectivity was prepared. can effectively detect 786-O-Nluc sensitively monitor xenograft nude mouse model without requiring stimuli like cysteine. Furthermore, allows real-time during progression. This work lays solid foundation future understanding biological functions

Language: Английский

Citations

1
Concurrent Subcellular Delivery of Hydrogen Sulfide and a Payload with Near-Infrared Light DOI Creative Commons

Katarzyna Hanc,

Hana Janeková, Peter Štacko

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(7), P. 2687 - 2694

Published: July 5, 2024

Hydrogen sulfide (H2S) is a gaseous signaling molecule, exerting crucial regulatory functions in organelles and cellular environments. H2S exhibits high therapeutic potential synergistic effects with other drugs, its potency notably enhanced through organelle-specific targeting. Yet, the navigation of light-activated donors to specific remains absent. Here, we report first photocage that simultaneously delivers payload subcellular precision mitochondria live human cells using tissue-penetrating near-infrared light as trigger. The fluorogenic enables real-time monitoring process, demonstrate concurrent uncaging combination fluorescence microscopy mitochondria-specific fluorescent probes. We anticipate these photocages will permit precise delivery H2S-drug combinations exceptional spatiotemporal control, thereby driving harnessing known discovery novel strategies.

Language: Английский

Citations

4
Frontiers in Fluorescence imaging: Tools for the In-Situ Sensing of Disease Biomarkers DOI
Lei Yang, Hongwei Hou, Jinghong Li

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

A comprehensive overview of recent advancements in fluorescence imaging techniques for situ sensing various biomarkers, emphasizing the transformative potential artificial intelligence shaping future bioimaging.

Language: Английский

Citations

4
An activatable Near-Infrared afterglow luminescent nanoprobe with ultralong Half-Life for in vivo H2S imaging DOI
Han Zhang,

Chengyuan Lv,

Wenkai Liu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157086 - 157086

Published: Oct. 1, 2024

Language: Английский

Citations

1
A Photo-triggered Dual-gas Donor of Nitric Oxide and Hydrogen Sulfide with Fluorescence to Real-time Monitor Its Release DOI
Anfu Hou,

Zhenmei Lin,

Yongfang Cheng

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 150(2), P. 378 - 385

Published: Dec. 3, 2024

A dual gas donor of nitric oxide and hydrogen sulfide is employed for photocontrolled release in cells can be utilized to investigate the synergistic effect two gases on inflammation cells.

Language: Английский

Citations

0