Targeting TGF-β signal transduction for fibrosis and cancer therapy

Molecular Cancer, Год журнала: 2022, Номер 21(1)

Опубликована: Апрель 23, 2022

Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, adult homeostasis. The role of TGF-β fibrosis cancer is complex sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage disease. Under pathological conditions, overexpressed causes epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) deposition, cancer-associated fibroblast (CAF) formation, which leads to fibrotic disease, cancer. Given critical downstream molecules progression cancers, therapeutics targeting signaling appears be a promising strategy. However, due potential systemic cytotoxicity, lagged. In this review, we summarized biological process TGF-β, dual tumorigenesis, clinical application TGF-β-targeting therapies.

Язык: Английский

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Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications

Frontiers in Chemistry, Год журнала: 2021, Номер 9

Опубликована: Июль 13, 2021

Diverse applications of nanoparticles (NPs) have revolutionized various sectors in society. In the recent decade, particularly magnetic (MNPs) gained enormous interest owing to their specialized areas such as medicine, cancer theranostics, biosensing, catalysis, agriculture, and environment. Controlled surface engineering for design multi-functional MNPs is vital achieving desired application. The demonstrated great efficacy thermoelectric materials, imaging agents, drug delivery vehicles, biosensors. present review, first we briefly discussed main synthetic methods MNPs, followed by characterizations composition. Then potential different with representative examples. At end, gave an overview on current challenges future prospects MNPs. This comprehensive review not only provides mechanistic insight into synthesis, functionalization, application but also outlines limits prospects.

Язык: Английский

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Magnetic nanoparticles in biomedical applications: A review

Applied Surface Science Advances, Год журнала: 2021, Номер 6, С. 100163 - 100163

Опубликована: Сен. 14, 2021

Biomedical applications with emphasis on the design of smart materials, specifically magnetic nanoparticles (MNPs) are considered to have technological benefits because they can be manipulated using fields. Magnetic NPs been widely used in hyperthermia, target drug delivery system, imaging, and extraction biomolecules, postulating them also as an important tool cancer treatment. Morphological structures materials drawn tremendous attention from diverse scientific fields due their unique surface chemistry, nontoxicity, biocompatibility, particularly inducible moment. This review features recent research accomplishments made biomedical field nanoparticles. The first part gives a comprehensive overview treatment chronic diseases targeting. second includes role electrochemical, optical-based immunoassays. outlines current challenges future perspectives for fostering advanced high-performance applications.

Язык: Английский

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Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management

ACS Nano, Год журнала: 2020, Номер 14(5), С. 5686 - 5699

Опубликована: Апрель 22, 2020

Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem, which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great potential in treatment biofilms, efficient penetration and retention still a big challenge. To address this issue, we herein fabricate size charge adaptive azithromycin (AZM)-conjugated clustered (denoted as AZM-DA NPs) therapeutic agents for treating biofilms. The NPs are prepared electrostatic complexation between AZM conjugated amino-ended poly(amidoamine) dendrimer (PAMAM) 2,3-dimethyl maleic anhydride (DA) modified poly(ethylene glycol)-block-polylysine (PEG-b-PLys). It noteworthy that disassemble acidic biofilm microenvironment (pH 6.0), leading release secondary AZM-conjugated PAMAM (PAMAM-AZM NPs). PAMAM-AZM with small positive beneficial improved inside enhanced permeabilization membrane, increased internalization AZM, thus exhibiting excellent antibiofilm activities. also favorable long-term antibacterial due reduced occurrence drug resistance. In vivo performance confirmed burden alleviated inflammation chronic model. This research not only develops innovative strategy delivery but provides effective way management biofilm-associated infections, including infection.

Язык: Английский

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Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Advanced Science, Год журнала: 2020, Номер 8(1)

Опубликована: Ноя. 27, 2020

The impermeable barrier of solid tumors due to the complexity their components limits treatment effect nanomedicine and hinders its clinical translation. Several methods are available increase penetrability nanomedicine, yet they too complex be effective, operational, or practical. Surface modification employs characteristics direct contact between multiphase surfaces achieve most efficient penetration tumors. Furthermore, simple operation makes use feasible. In this review, latest surface strategies for into summarized classified "bulldozer strategies" "mouse strategies." Additionally, evaluation methods, existing problems, development prospects these technologies discussed.

Язык: Английский

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Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 112951 - 112951

Опубликована: Апрель 18, 2022

The current advancements in nanotechnology are as an outcome of the development engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot attention field due to their significant inert nature, and nanoscale structures, with size similar many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle such size, shape, environment, aspect ratio, ease synthesis functionalization properties led numerous applications fields biomedicine. These targeted drug delivery, sensing, photothermal photodynamic therapy, imaging, well modulation two or three article also discusses about cancer imaging therapeutics. associated bottlenecks related clinical translation discussed.

Язык: Английский

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Advances of peptides for antibacterial applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2021, Номер 202, С. 111682 - 111682

Опубликована: Март 9, 2021

Язык: Английский

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Magnetic nanoparticles for cancer theranostics: Advances and prospects

Journal of Controlled Release, Год журнала: 2021, Номер 335, С. 437 - 448

Опубликована: Май 31, 2021

Язык: Английский

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3-Bromopyruvate-Conjugated Nanoplatform-Induced Pro-Death Autophagy for Enhanced Photodynamic Therapy against Hypoxic Tumor

ACS Nano, Год журнала: 2020, Номер 14(8), С. 9711 - 9727

Опубликована: Июль 27, 2020

Autophagy triggered by reactive oxygen species (ROS) in photodynamic therapy (PDT) generally exhibits an anti-apoptotic effect to promote cell survival. Herein, innovative supramolecular nanoplatform was fabricated for enhanced PDT converting the role of autophagy from pro-survival pro-death. The respiration inhibitor 3-bromopyruvate (3BP), which can act as promoter and hypoxia ameliorator, integrated into photosensitizer chlorin e6 (Ce6)-encapsulated nanoparticles combat hypoxic tumor. 3BP could inhibit down-regulating HK-II GAPDH expression significantly reduce intracellular consumption rate, relieve tumor cancer therapy. More importantly, level elevated combination determined Western blot, immunofluorescent imaging, transmission electron microscopy. It very surprising that excessively activated promoted apoptosis, leading changeover Therefore, combined with achieve efficient proliferation inhibition regression. Furthermore, hypoxia-inducible factor-1α (HIF-1α) be down-regulated after relieved 3BP. Tumor metastasis then effectively inhibited eliminating primary tumors HIF-1α expression. These results provide inspiration future approaches triggering pro-death autophagy.

Язык: Английский

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Understanding and targeting resistance mechanisms in cancer

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Май 22, 2023

Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes treatment failure and poor patient survival. The reduced responsiveness cells multifaceted that can arise from genetic, epigenetic, microenvironmental factors. Various mechanisms have discovered extensively studied, including drug inactivation, intracellular accumulation by uptake or increased efflux, target alteration, activation compensatory pathways for cell survival, regulation DNA repair death, tumor plasticity, microenvironments (TMEs). To overcome resistance, variety strategies proposed, are designed enhance effectiveness reduce resistance. These include identifying biomarkers predict response new targets, developing targeted drugs, combination targeting multiple signaling pathways, modulating TME. present article focuses on different resistance corresponding tackling approaches with recent updates. Perspectives polytherapy mechanisms, novel nanoparticle delivery systems, advanced design tools overcoming also reviewed.

Язык: Английский

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