Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442

Опубликована: Янв. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Язык: Английский

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Physicochemical properties and interactions of perfluoroalkyl substances (PFAS) - Challenges and opportunities in sensing and remediation

The Science of The Total Environment, Год журнала: 2023, Номер 905, С. 166764 - 166764

Опубликована: Сен. 1, 2023

Per- and polyfluoroalkyl substances (PFAS) is a class of persistent organic pollutants that presents health environmental risks. PFAS are ubiquitously present in the environment, but current remediation technologies ineffective degrading them into innocuous chemicals, especially high energy degradation processes often generate toxic short chain intermediates. Therefore, best strategy to first detect source pollution, followed by capturing mineralising or recycling compounds. The main objective this article summarise unique physicochemical properties critically review intermolecular intramolecular interactions PFAS, how these can become obstacles; at same time, they be applied sensing, capturing, process. chemicals being reviewed paper includes, (1) fluorophilic interactions, (2) hydrophobic (3) electrostatic cation bridging, (4) ionic exchange (5) hydrogen bond. Moreover, all different influential factors have also been reported. Finally, compared against one another, recommendations for future designs affinity materials given.

Язык: Английский

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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chemical Reviews, Год журнала: 2023, Номер 123(24), С. 13966 - 14037

Опубликована: Ноя. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Язык: Английский

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Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma

Biomaterials, Год журнала: 2023, Номер 301, С. 122212 - 122212

Опубликована: Июнь 24, 2023

Язык: Английский

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Coordination-Assembled Water-Soluble Anionic Lanthanide Organic Polyhedra for Luminescent Labeling and Magnetic Resonance Imaging

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(38), С. 16409 - 16419

Опубликована: Сен. 3, 2020

Lanthanide-containing functional complexes have found a variety of applications in materials science and biomedicine because their unique electroptical magnetic properties. However, the poor stability solubility water multicomponent lanthanide organic assemblies significantly limit practical applications. We report here series water-stable anionic Ln2nL3n-type (n = 2, 3, 4, 5) polyhedra (LOPs) constructed by deprotonation self-assembly three fully conjugated ligands (H4L1 H4L2a/b) featuring 2,6-pyridine bitetrazolate chelating moiety. The outcomes LOPs formation reactions were to be very sensitive toward reaction conditions including base, metal source, solvents, concentrations as characterized combination NMR, high-resolution ESI-MS X-ray crystallography. Ligands H4L2a/b manifested an excellent sensitization ions (Ln EuIII TbIII), with high luminescent quantum yields for Tb8L2a12 (Φ 11.2% water) Eu8L2b12 76.8% DMSO) measured polar solvents. Furthermore, due giant molecular weight rigidity polyhedral skeleton, Gd8L2b12 showed longitudinal relaxivity (r1) 400.53 mM-1S-1. performance potential resonance imaging contrast agents (CAs) vivo was evaluated much longer retention time tumor sites compared commercial GdIII-based CAs. Dual-modal has also been demonstrated mixed Eu/Gd LOPs. Our results not only provide new design route multinuclear but offer candidates supramolecular-edifices bioimaging drug delivery.

Язык: Английский

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Phosphorescent iridium(III) complexes as lifetime-based biological sensors for photoluminescence lifetime imaging microscopy

Coordination Chemistry Reviews, Год журнала: 2021, Номер 453, С. 214334 - 214334

Опубликована: Дек. 9, 2021

Язык: Английский

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Lanthanide-doped lead-free double perovskite La₂MgTiO₆ as ultra-bright multicolour LEDs and novel self-calibrating partition optical thermometer

Inorganic Chemistry Frontiers, Год журнала: 2023, Номер 10(11), С. 3383 - 3395

Опубликована: Янв. 1, 2023

Multicolour LEDs and a self-calibrating partition thermometer are designed based on the excellent lanthanide compatibility of double perovskite La 2 MgTiO 6 .

Язык: Английский

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Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Abstract The lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging biosensing applications. While most complexes emitting visible light are extensively studied cellular‐level detection bioimaging, near‐infrared‐emitted (700–1700 nm) compounds exhibit more favorable properties bioimaging biosensing, ascribed from deeper penetration reduced bleaching effects. Besides, the complex with higher resonance signals can enhance image resolution sensitivity, offering precise analysis. However, widespread use of high‐efficiency is currently impeded lack design approaches improving sensitization chromophores extended excitation wavelengths. In this review, some fundamental theories strategies summarized imaging, lifetime‐engineered dual‐modal now highlight a selection review addresses existing gap in literature proposing feasible fluorescent properties. Concurrently, future challenges opportunities field probes discussed.

Язык: Английский

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Luminescence, chiroptical, magnetic andab initiocrystal-field characterizations of an enantiopure helicoidal Yb(iii) complex

Inorganic Chemistry Frontiers, Год журнала: 2020, Номер 8(4), С. 914 - 926

Опубликована: Окт. 30, 2020

The electronic structure of a chiral Yb(iii)-based complex is fully determined by taking advantage experimental magnetic, luminescence, and chiroptical (NIR-ECD CPL) characterizations in combination withab initiowavefunction calculations.

Язык: Английский

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Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

Nanomaterials, Год журнала: 2020, Номер 10(10), С. 2015 - 2015

Опубликована: Окт. 13, 2020

The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application imaging systems; the afterglow emission grants background-free imaging, there is no need continuous excitation avoid tissue cell damage due light exposure, they also circumvent depth penetration issue caused by UV-Vis. This review aims provide a background systems, persistent luminescence, synthetic methods obtaining materials, discuss selected examples recent literature on applications photodynamic therapy. Finally, challenges future directions, pointing development compounds capable executing multiple functions regions where tissues cells low absorption, will be discussed.

Язык: Английский

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