Near‐Infrared Bioimaging Using Two‐photon Fluorescent Probes DOI

Pragti Pragti,

Bidyut Kumar Kundu, Rui Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Near‐infrared (NIR) bioimaging has emerged as a transformative technology in biomedical research. Among many fluorescent probes that are suitable for NIR imaging studies, two‐photon absorption (TPA) ones represent particularly promising category, because TPA can overcome the inherent limitations of one‐photon (OPA) counterparts. By leveraging unique properties absorption, achieve superior tissue penetration, significantly reduced photodamage, and enhanced spatial resolution. This perspective article delves into fundamental principles, design strategies, representative various applications. In particular, number molecular probes, ranging from organic, inorganic, COF/MOF‐based systems highlighted to showcase vast scope possible probe application scenarios. addition, employment stimulated responsive different external factors, including pH, redox species, enzymes, hypoxia, is also discussed. end, future perspectives continuous advancement field presented. For instance, it essential transition cellular vivo studies obtain more physiologically relevant insights. Additionally, development “dual‐function” both disease diagnosis therapeutic treatment promising.

Language: Английский

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications DOI

Chonglu Li,

Yida Pang,

Yuling Xu

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

Citations

93
Physicochemical properties and interactions of perfluoroalkyl substances (PFAS) - Challenges and opportunities in sensing and remediation DOI Creative Commons

Shui Cheung Edgar Leung,

Dushanthi Wanninayake, Dechao Chen

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 166764 - 166764

Published: Sept. 1, 2023

Per- and polyfluoroalkyl substances (PFAS) is a class of persistent organic pollutants that presents health environmental risks. PFAS are ubiquitously present in the environment, but current remediation technologies ineffective degrading them into innocuous chemicals, especially high energy degradation processes often generate toxic short chain intermediates. Therefore, best strategy to first detect source pollution, followed by capturing mineralising or recycling compounds. The main objective this article summarise unique physicochemical properties critically review intermolecular intramolecular interactions PFAS, how these can become obstacles; at same time, they be applied sensing, capturing, process. chemicals being reviewed paper includes, (1) fluorophilic interactions, (2) hydrophobic (3) electrostatic cation bridging, (4) ionic exchange (5) hydrogen bond. Moreover, all different influential factors have also been reported. Finally, compared against one another, recommendations for future designs affinity materials given.

Language: Английский

Citations

71
Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window DOI
Baisong Chang, Jie Chen,

Jiasheng Bao

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

Citations

50
Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma DOI
Tao Feng, Zixin Tang, Johannes Karges

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122212 - 122212

Published: June 24, 2023

Language: Английский

Citations

47
Coordination-Assembled Water-Soluble Anionic Lanthanide Organic Polyhedra for Luminescent Labeling and Magnetic Resonance Imaging DOI
Zhuo Wang, Lizhen He, Bingqing Liu

et al.

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(38), P. 16409 - 16419

Published: Sept. 3, 2020

Lanthanide-containing functional complexes have found a variety of applications in materials science and biomedicine because their unique electroptical magnetic properties. However, the poor stability solubility water multicomponent lanthanide organic assemblies significantly limit practical applications. We report here series water-stable anionic Ln2nL3n-type (n = 2, 3, 4, 5) polyhedra (LOPs) constructed by deprotonation self-assembly three fully conjugated ligands (H4L1 H4L2a/b) featuring 2,6-pyridine bitetrazolate chelating moiety. The outcomes LOPs formation reactions were to be very sensitive toward reaction conditions including base, metal source, solvents, concentrations as characterized combination NMR, high-resolution ESI-MS X-ray crystallography. Ligands H4L2a/b manifested an excellent sensitization ions (Ln EuIII TbIII), with high luminescent quantum yields for Tb8L2a12 (Φ 11.2% water) Eu8L2b12 76.8% DMSO) measured polar solvents. Furthermore, due giant molecular weight rigidity polyhedral skeleton, Gd8L2b12 showed longitudinal relaxivity (r1) 400.53 mM-1S-1. performance potential resonance imaging contrast agents (CAs) vivo was evaluated much longer retention time tumor sites compared commercial GdIII-based CAs. Dual-modal has also been demonstrated mixed Eu/Gd LOPs. Our results not only provide new design route multinuclear but offer candidates supramolecular-edifices bioimaging drug delivery.

Language: Английский

Citations

104
Phosphorescent iridium(III) complexes as lifetime-based biological sensors for photoluminescence lifetime imaging microscopy DOI
Jie Zhou, Jinlu Li, Kenneth Yin Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 453, P. 214334 - 214334

Published: Dec. 9, 2021

Language: Английский

Citations

71
Lanthanide-doped lead-free double perovskite La2MgTiO6 as ultra-bright multicolour LEDs and novel self-calibrating partition optical thermometer DOI

Keming Zhu,

Hanyu Xu,

Zhiying Wang

et al.

Inorganic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(11), P. 3383 - 3395

Published: Jan. 1, 2023

Multicolour LEDs and a self-calibrating partition thermometer are designed based on the excellent lanthanide compatibility of double perovskite La 2 MgTiO 6 .

Language: Английский

Citations

28
Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications DOI
Yanling Yang, Xiaoming Hu, Zhèn Yáng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Abstract The lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging biosensing applications. While most complexes emitting visible light are extensively studied cellular‐level detection bioimaging, near‐infrared‐emitted (700–1700 nm) compounds exhibit more favorable properties bioimaging biosensing, ascribed from deeper penetration reduced bleaching effects. Besides, the complex with higher resonance signals can enhance image resolution sensitivity, offering precise analysis. However, widespread use of high‐efficiency is currently impeded lack design approaches improving sensitization chromophores extended excitation wavelengths. In this review, some fundamental theories strategies summarized imaging, lifetime‐engineered dual‐modal now highlight a selection review addresses existing gap in literature proposing feasible fluorescent properties. Concurrently, future challenges opportunities field probes discussed.

Language: Английский

Citations

13
Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics DOI Creative Commons
Carlson Alexander, Zhilin Guo,

P.B. Glover

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Lanthanides are particularly effective in their clinical applications magnetic resonance imaging and diagnostic assays. They have open-shell 4f electrons that give rise to characteristic narrow, line-like emission which is unique from other fluorescent probes biological systems. Lanthanide luminescence signal offers selection of detection pathways based on the choice ion visible near-infrared with long lifetimes lend themselves time-resolved measurements for optical multiplexing schemes novel bioimaging applications. The delivery lanthanide agents cells allows localized bioresponsive activity therapies. Detection region spectrum coupled technological advances microscopies opens new avenues deep-tissue surgical interventions. This review focuses different ways can be exploited nucleic acid enzyme detection, anion recognition, cellular imaging, tissue photoinduced therapeutic We focused hierarchy designs include luminescent lanthanides as biology considering coordination complexes, multimetallic systems metal-organic frameworks nanoparticles highlighting strategies downshifting, upconversion revealing some opportunities challenges offer potential further development field.

Language: Английский

Citations

1
Luminescence, chiroptical, magnetic andab initiocrystal-field characterizations of an enantiopure helicoidal Yb(iii) complex DOI
Frédéric Gendron, Sebastiano Di Pietro, Laura Abad Galán

et al.

Inorganic Chemistry Frontiers, Journal Year: 2020, Volume and Issue: 8(4), P. 914 - 926

Published: Oct. 30, 2020

The electronic structure of a chiral Yb(iii)-based complex is fully determined by taking advantage experimental magnetic, luminescence, and chiroptical (NIR-ECD CPL) characterizations in combination withab initiowavefunction calculations.

Language: Английский

Citations

55