In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(5), С. 2360 - 2367

Опубликована: Янв. 20, 2022

Considering that hypoxia is closely associated with tumor proliferation, invasion, metastasis, and drug resistance, it of great significance to overcome in treatment. Herein, we report a hypoxia-induced specific photothermal therapy (PTT) based on the agent supramolecular perylene diimide radical anions. Hypoxic regions various tumors display strong reductive ability, such environments complex derivative cucurbit[7]uril could be reduced Benefiting from NIR absorption good conversion performance situ generated anions, PTT strategy exhibits excellent therapeutic efficiency as well specificity biological safety. Moreover, inducible factor expression decreases normal level after It anticipated opens new horizons for against hypoxic improved

Язык: Английский

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Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(25), С. 11326 - 11337

Опубликована: Июнь 16, 2022

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as promising approach to cancer immunotherapy. However, biocompatible strategies activate pyroptosis remain rare. Here, we show that photocatalytic superoxide radical (O2-•) generator, NI-TA, triggers in cells. NI-TA was designed take advantage an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed the triggered by under conditions photoexcitation proceeds through caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). found function partial-O2-recycling mode action and trigger provide for effective ablation even hypoxia (≤2% O2). In case T47D 3D multicellular spheroids, good antitumor efficiency stemness inhibition are achieved. This work highlights how chemistry may be leveraged develop pyroptosis-inducing agents.

Язык: Английский

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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 879 - 920

Опубликована: Янв. 1, 2023

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables development improved therapies.

Язык: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2699 - 2804

Опубликована: Фев. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Язык: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2022, Номер 476, С. 214908 - 214908

Опубликована: Ноя. 7, 2022

Язык: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Год журнала: 2023, Номер 36(21)

Опубликована: Июль 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Язык: Английский

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Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod

ACS Nano, Год журнала: 2022, Номер 16(7), С. 10979 - 10993

Опубликована: Июнь 19, 2022

Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 agonist, is commonly used in clinical settings immune adjuvant. We prepared activatable sonodynamic sensitizer platform (MR) based on glutathione-sensitive disulfide bonds linking Leu-MB, the reduced form of methylene blue (MB), and R837 to achieve efficient combinatory SDT immunotherapy tumors without harming normal tissues. also amphiphilic polymer C18PMH-PEG create self-assembled MB-R837-PEG (MRP) nanoparticles immunosonodynamic (iSDT). iSDT cancer that combines immunotherapy. Our demonstrated excellent effect only at tumor site, demonstrating high specificity killing cells when compared reported literature. The improves its tumor-killing by inducing response, which accomplished secreted adjuvants site. MRP was selectively activated glutathione microenvironment release MB R837, exhibiting antitumor responses. In addition, combined with α-PD-L1 antibody checkpoint blockade, this effectively inhibited metastasis. mice treated did not develop even after reinoculation, indicating long-term memory achieved. concept preparation next-generation synergistic therapeutic modality applicable near future presented study.

Язык: Английский

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Год журнала: 2023, Номер 33(29)

Опубликована: Июнь 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Язык: Английский

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3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(18)

Опубликована: Март 14, 2023

Abstract Decades of efforts in engineering vitro cancer models have advanced drug discovery and the insight into biology. However, establishment preclinical that enable fully recapitulating tumor microenvironment remains challenging owing to its intrinsic complexity. Recent progress techniques has allowed development a new generation can recreate complex vivo microenvironments accurately predict responses, including spheroids, organoids, tumor‐on‐a‐chip. These biomimetic 3D are particular interest as they pave way for better understanding biology accelerating anticancer therapeutics with reducing animal use. Here, recent advances developing these platforms modeling screening, focusing on incorporating hydrogels reviewed reconstitute physiologically relevant microenvironments. The combination spheroids/organoids microfluidic technologies is also highlighted mimic tumors discuss challenges future directions clinical translation such screening personalized medicine.

Язык: Английский

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Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment

Biomedicines, Год журнала: 2024, Номер 12(6), С. 1353 - 1353

Опубликована: Июнь 18, 2024

Apigenin is a powerful flavone compound found in numerous fruits and vegetables, it offers health-promoting benefits. Many studies have evidenced that this has potential role as an anti-inflammatory antioxidant compound, making promising candidate for reducing the risk of pathogenesis. It also been to positively affect various systems body, such respiratory, digestive, immune, reproductive systems. effective treating liver, lung, heart, kidney, neurological diseases, diabetes, maintaining good oral skin health. Multiple reported capable suppressing types cancer through induction apoptosis cell-cycle arrest, cell migration invasion, reduction inflammation, inhibiting angiogenesis. When used combination with other drugs, apigenin increases their efficacy, reduces side effects, improves response chemotherapy. This review broadly analyzes apigenin’s disease management by modulating biological activities. In addition, described interaction compounds or drugs nanoformulation different pathogeneses. Further extensive research needed explore mechanism action, safety, efficacy prevention treatment.

Язык: Английский

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