Glioblastoma
multiforme
(GBM)
is
the
most
aggressive
and
lethal
subtype
of
gliomas
central
nervous
system.
The
efficacy
sonodynamic
therapy
(SDT)
against
GBM
significantly
reduced
by
expression
apoptosis-inhibitory
proteins
in
cells.
In
this
study,
an
intelligent
nanoplatform
(denoted
as
Aza-BD@PC
NPs)
based
on
aza-boron-dipyrromethene
dye
phenyl
chlorothionocarbonate-modified
DSPE-PEG
molecules
developed
for
synergistic
ferroptosis-enabled
gas
(GT)
SDT
GBM.
Once
internalized
cells,
NPs
showed
effective
cysteine
(Cys)
consumption
Cys-triggered
hydrogen
sulfide
(H
Bioactive Materials,
Год журнала:
2023,
Номер
32, С. 66 - 97
Опубликована: Сен. 29, 2023
Ferroptosis
offers
a
novel
method
for
overcoming
therapeutic
resistance
of
cancers
to
conventional
cancer
treatment
regimens.
Its
effective
use
as
therapy
requires
precisely
targeted
approach,
which
can
be
facilitated
by
using
nanoparticles
and
nanomedicine,
their
enhance
ferroptosis
is
indeed
growing
area
research.
While
few
review
papers
have
been
published
on
iron-dependent
mechanism
inducers
that
partly
covers
nanoparticles,
there
need
comprehensive
focusing
the
design
magnetic
typically
supply
iron
ions
promote
simultaneously
enable
nanomedicine.
Furthermore,
locally
induce
combinational
with
diagnostic
resonance
imaging
(MRI).
The
remotely
controllable
nanocarriers
offer
highly
localized
image-guided
Here,
recent
developments
in
magnetically
manipulable
nanomedicine
medical
are
summarized.
This
also
highlights
advantages
current
state-of-the-art
Finally,
image
guided
apoptosis-based
enables
synergistic
tumor
discussed
clinical
translations.
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 185 - 202
Опубликована: Март 5, 2024
Wound
healing
in
cases
of
excessive
inflammation
poses
a
significant
challenge
due
to
compromised
neovascularization.
Here,
we
propose
multi-functional
composite
hydrogel
engineered
overcome
such
conditions
through
recruitment
and
activation
macrophages
with
adapted
degradation
the
hydrogel.
The
(G-TSrP)
is
created
by
combining
gelatin
methacryloyl
(GelMA)
nanoparticles
(TSrP)
composed
tannic
acid
(TA)
Sr2+.
These
are
prepared
using
one-step
mineralization
process
assisted
metal-phenolic
network
formation.
G-TSrP
exhibits
ability
eliminate
reactive
oxygen
species
direct
polarization
toward
M2
phenotype.
It
has
been
observed
that
liberation
TA
Sr2+
from
actively
facilitate
up-regulation
expression
extracellular
matrix
remodeling
genes
macrophages,
thereby,
coordinate
vivo
G-TSrP.
Most
significantly,
accelerates
angiogenesis
despite
TA's
inhibitory
properties,
which
counteracted
released
Moreover,
enhances
wound
closure
under
promotes
normal
tissue
formation
strong
vessel
growth.
Genetic
analysis
confirms
macrophage-mediated
Collectively,
these
findings
pave
way
for
development
biomaterials
promote
creating
regenerative
environment.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Март 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Native
tissues
exhibit
hierarchical
structures
of
anisotropically
arranged
extracellular
matrix
that
dynamically
regulate
stem
cells
and
tissue
function.
However,
neither
multiscale
nano‐anisotropy
nor
dynamic
anisotropy
control
have
been
reported.
In
this
study,
spherical
or
rod‐shaped
gold
small‐nanomaterials
(at
integrin
receptor‐scale;
tens
nanometers)
are
coupled
to
the
surface
magnetic
large‐nanomaterials
focal
adhesion
complex‐scale;
hundreds
nanometers),
with
both
showing
constant
areas
at
each
respective
scale.
Each
nanocomposite
is
flexibly
conjugated
substrate
material
densities,
resulting
in
dual‐scale
liganded
nano‐anisotropies.
Increasing
aspect
ratio
nanomaterials
nanometer‐scale
dominantly
promotes
recruitment,
adhesion,
mechanotransduction,
differentiation
over
nanometer‐scale.
Such
scale‐specific
effects
on
cell
regulation
temporally
regulated
vitro
vivo
by
physically
raising
lowering
nanocomposites
respectively
inhibit
stimulate
curved
surfaces
modulating
membrane
bending.
unprecedented
“dynamic
ligand
anisotropy”
can
be
independently
engineered
regarding
scales,
anisotropies,
ligands
elucidate
cell‐material
interactions
allow
for
multimodal
enhance
tissue‐regenerative
therapy.
Chemical Society Reviews,
Год журнала:
2022,
Номер
52(1), С. 30 - 46
Опубликована: Дек. 13, 2022
Mechanical
stimulation
utilizing
deep
tissue-penetrating
and
focusable
energy
sources,
such
as
ultrasound
magnetic
fields,
is
regarded
an
emerging
patient-friendly
effective
therapeutic
strategy
to
overcome
the
limitations
of
conventional
cancer
therapies
based
on
fundamental
external
stimuli
light,
heat,
electricity,
radiation,
or
microwaves.
Recent
efforts
have
suggested
that
mechanical
stimuli-driven
therapy
(henceforth
referred
"mechanical
therapy")
could
provide
a
direct
effect
intelligent
control
augment
other
anti-cancer
systems
synergistic
combinational
treatment.
This
review
article
highlights
latest
advances
in
present
novel
perspective
principles
ultrasound-
field-mediated
forces,
including
compression,
tension,
shear
force,
torque,
can
be
generated
cellular
microenvironment
using
stimuli-activated
functional
materials.
Additionally,
this
will
shed
light
inspire
future
research
pursue
development
magnetic-field-activated
materials
their
applications
field.
