Static and Dynamic Biomaterial Engineering for Cell Modulation DOI Creative Commons
Hyung-Joon Park, Hyunsik Hong, Ramar Thangam

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(8), P. 1377 - 1377

Published: April 17, 2022

In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various processes. Specifically, physical and chemical properties of ECM work cooperatively to influence behavior fate directly indirectly, invokes physiological responses in body. Hence, efficient strategies modulate cellular for a specific purpose have become important scientific fields such as biology, pharmacy, medicine. Among many approaches, utilization biomaterials has been studied most because can be meticulously engineered mimic modulatory behavior. For careful engineering, studies on modulation (e.g., topography, stiffness, wettability) manipulation composition soluble surface biosignals) actively conducted. At present, scope research is being shifted from static (considering only initial environment effects each element) biomimetic dynamic (including concepts time gradient) both manipulations. This review provides overall perspective how targeted while highlighting importance advance biomedical applications.

Language: Английский

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging DOI Creative Commons
Min Jun Ko, Sunhong Min, Hyunsik Hong

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

Citations

58

Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization DOI Creative Commons
Hayeon Byun, Yu‐Jin Han,

Eunhyung Kim

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 185 - 202

Published: March 5, 2024

Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose multi-functional composite hydrogel engineered overcome such conditions through recruitment and activation macrophages with adapted degradation the hydrogel. The (G-TSrP) is created by combining gelatin methacryloyl (GelMA) nanoparticles (TSrP) composed tannic acid (TA) Sr2+. These are prepared using one-step mineralization process assisted metal-phenolic network formation. G-TSrP exhibits ability eliminate reactive oxygen species direct polarization toward M2 phenotype. It has been observed that liberation TA Sr2+ from actively facilitate up-regulation expression extracellular matrix remodeling genes macrophages, thereby, coordinate vivo G-TSrP. Most significantly, accelerates angiogenesis despite TA's inhibitory properties, which counteracted released Moreover, enhances wound closure under promotes normal tissue formation strong vessel growth. Genetic analysis confirms macrophage-mediated Collectively, these findings pave way for development biomaterials promote creating regenerative environment.

Language: Английский

Citations

34

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

27

A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells DOI
Chen Xiao, Xing Wang, Shiyou Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763

Published: Aug. 17, 2024

Language: Английский

Citations

25

Advances in covalent organic frameworks for cancer phototherapy DOI
Nem Singh, Miae Won, Jusung An

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215720 - 215720

Published: Feb. 16, 2024

Language: Английский

Citations

20

Antimicrobial carbon materials-based quantum dots: From synthesis strategies to antibacterial properties for diagnostic and therapeutic applications in wound healing DOI
Iman Zare,

Shima Zahed Nasab,

Amid Rahi

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216211 - 216211

Published: Sept. 18, 2024

Language: Английский

Citations

20

Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine DOI
Marzieh Ramezani Farani, Iman Zare,

Mojdeh Mirshafiei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

Citations

4

Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

3

Mechanical stimuli-driven cancer therapeutics DOI
Jusung An, Hyunsik Hong, Miae Won

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 30 - 46

Published: Dec. 13, 2022

Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources, such as ultrasound magnetic fields, is regarded an emerging patient-friendly effective therapeutic strategy to overcome the limitations of conventional cancer therapies based on fundamental external stimuli light, heat, electricity, radiation, or microwaves. Recent efforts have suggested that mechanical stimuli-driven therapy (henceforth referred "mechanical therapy") could provide a direct effect intelligent control augment other anti-cancer systems synergistic combinational treatment. This review article highlights latest advances in present novel perspective principles ultrasound- field-mediated forces, including compression, tension, shear force, torque, can be generated cellular microenvironment using stimuli-activated functional materials. Additionally, this will shed light inspire future research pursue development magnetic-field-activated materials their applications field.

Language: Английский

Citations

67

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation DOI
Haonan Li, Qiang Luo, Hu Zhang

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 47 - 96

Published: Nov. 25, 2022

This review overviews the landscape of nanomedicine-aided cancer radio-immunotherapy in a “from bench to clinic” manner.

Language: Английский

Citations

53