Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(8), P. 1377 - 1377
Published: April 17, 2022
In
the
biological
microenvironment,
cells
are
surrounded
by
an
extracellular
matrix
(ECM),
with
which
they
dynamically
interact
during
various
processes.
Specifically,
physical
and
chemical
properties
of
ECM
work
cooperatively
to
influence
behavior
fate
directly
indirectly,
invokes
physiological
responses
in
body.
Hence,
efficient
strategies
modulate
cellular
for
a
specific
purpose
have
become
important
scientific
fields
such
as
biology,
pharmacy,
medicine.
Among
many
approaches,
utilization
biomaterials
has
been
studied
most
because
can
be
meticulously
engineered
mimic
modulatory
behavior.
For
careful
engineering,
studies
on
modulation
(e.g.,
topography,
stiffness,
wettability)
manipulation
composition
soluble
surface
biosignals)
actively
conducted.
At
present,
scope
research
is
being
shifted
from
static
(considering
only
initial
environment
effects
each
element)
biomimetic
dynamic
(including
concepts
time
gradient)
both
manipulations.
This
review
provides
overall
perspective
how
targeted
while
highlighting
importance
advance
biomedical
applications.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
32, P. 66 - 97
Published: Sept. 29, 2023
Ferroptosis
offers
a
novel
method
for
overcoming
therapeutic
resistance
of
cancers
to
conventional
cancer
treatment
regimens.
Its
effective
use
as
therapy
requires
precisely
targeted
approach,
which
can
be
facilitated
by
using
nanoparticles
and
nanomedicine,
their
enhance
ferroptosis
is
indeed
growing
area
research.
While
few
review
papers
have
been
published
on
iron-dependent
mechanism
inducers
that
partly
covers
nanoparticles,
there
need
comprehensive
focusing
the
design
magnetic
typically
supply
iron
ions
promote
simultaneously
enable
nanomedicine.
Furthermore,
locally
induce
combinational
with
diagnostic
resonance
imaging
(MRI).
The
remotely
controllable
nanocarriers
offer
highly
localized
image-guided
Here,
recent
developments
in
magnetically
manipulable
nanomedicine
medical
are
summarized.
This
also
highlights
advantages
current
state-of-the-art
Finally,
image
guided
apoptosis-based
enables
synergistic
tumor
discussed
clinical
translations.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
36, P. 185 - 202
Published: March 5, 2024
Wound
healing
in
cases
of
excessive
inflammation
poses
a
significant
challenge
due
to
compromised
neovascularization.
Here,
we
propose
multi-functional
composite
hydrogel
engineered
overcome
such
conditions
through
recruitment
and
activation
macrophages
with
adapted
degradation
the
hydrogel.
The
(G-TSrP)
is
created
by
combining
gelatin
methacryloyl
(GelMA)
nanoparticles
(TSrP)
composed
tannic
acid
(TA)
Sr2+.
These
are
prepared
using
one-step
mineralization
process
assisted
metal-phenolic
network
formation.
G-TSrP
exhibits
ability
eliminate
reactive
oxygen
species
direct
polarization
toward
M2
phenotype.
It
has
been
observed
that
liberation
TA
Sr2+
from
actively
facilitate
up-regulation
expression
extracellular
matrix
remodeling
genes
macrophages,
thereby,
coordinate
vivo
G-TSrP.
Most
significantly,
accelerates
angiogenesis
despite
TA's
inhibitory
properties,
which
counteracted
released
Moreover,
enhances
wound
closure
under
promotes
normal
tissue
formation
strong
vessel
growth.
Genetic
analysis
confirms
macrophage-mediated
Collectively,
these
findings
pave
way
for
development
biomaterials
promote
creating
regenerative
environment.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
52(1), P. 30 - 46
Published: Dec. 13, 2022
Mechanical
stimulation
utilizing
deep
tissue-penetrating
and
focusable
energy
sources,
such
as
ultrasound
magnetic
fields,
is
regarded
an
emerging
patient-friendly
effective
therapeutic
strategy
to
overcome
the
limitations
of
conventional
cancer
therapies
based
on
fundamental
external
stimuli
light,
heat,
electricity,
radiation,
or
microwaves.
Recent
efforts
have
suggested
that
mechanical
stimuli-driven
therapy
(henceforth
referred
"mechanical
therapy")
could
provide
a
direct
effect
intelligent
control
augment
other
anti-cancer
systems
synergistic
combinational
treatment.
This
review
article
highlights
latest
advances
in
present
novel
perspective
principles
ultrasound-
field-mediated
forces,
including
compression,
tension,
shear
force,
torque,
can
be
generated
cellular
microenvironment
using
stimuli-activated
functional
materials.
Additionally,
this
will
shed
light
inspire
future
research
pursue
development
magnetic-field-activated
materials
their
applications
field.
