Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H2S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies DOI Creative Commons
Jiajia Zhao, Erbao Bian, Renwu Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 13, 2024

Glioblastoma multiforme (GBM) is the most aggressive and lethal subtype of gliomas central nervous system. The efficacy sonodynamic therapy (SDT) against GBM significantly reduced by expression apoptosis-inhibitory proteins in cells. In this study, an intelligent nanoplatform (denoted as Aza-BD@PC NPs) based on aza-boron-dipyrromethene dye phenyl chlorothionocarbonate-modified DSPE-PEG molecules developed for synergistic ferroptosis-enabled gas (GT) SDT GBM. Once internalized cells, NPs showed effective cysteine (Cys) consumption Cys-triggered hydrogen sulfide (H

Language: Английский

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging DOI Creative Commons
Min Jun Ko, Sunhong Min, Hyunsik Hong

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

Citations

57

Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization DOI Creative Commons
Hayeon Byun, Yu‐Jin Han,

Eunhyung Kim

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 185 - 202

Published: March 5, 2024

Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose multi-functional composite hydrogel engineered overcome such conditions through recruitment and activation macrophages with adapted degradation the hydrogel. The (G-TSrP) is created by combining gelatin methacryloyl (GelMA) nanoparticles (TSrP) composed tannic acid (TA) Sr2+. These are prepared using one-step mineralization process assisted metal-phenolic network formation. G-TSrP exhibits ability eliminate reactive oxygen species direct polarization toward M2 phenotype. It has been observed that liberation TA Sr2+ from actively facilitate up-regulation expression extracellular matrix remodeling genes macrophages, thereby, coordinate vivo G-TSrP. Most significantly, accelerates angiogenesis despite TA's inhibitory properties, which counteracted released Moreover, enhances wound closure under promotes normal tissue formation strong vessel growth. Genetic analysis confirms macrophage-mediated Collectively, these findings pave way for development biomaterials promote creating regenerative environment.

Language: Английский

Citations

31

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

27

A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells DOI
Chen Xiao, Xing Wang, Shiyou Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763

Published: Aug. 17, 2024

Language: Английский

Citations

23

Advances in covalent organic frameworks for cancer phototherapy DOI
Nem Singh, Miae Won, Jusung An

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215720 - 215720

Published: Feb. 16, 2024

Language: Английский

Citations

20

Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

3

Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine DOI
Marzieh Ramezani Farani, Iman Zare,

Mojdeh Mirshafiei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

Citations

3

Mechanical stimuli-driven cancer therapeutics DOI
Jusung An, Hyunsik Hong, Miae Won

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 30 - 46

Published: Dec. 13, 2022

Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources, such as ultrasound magnetic fields, is regarded an emerging patient-friendly effective therapeutic strategy to overcome the limitations of conventional cancer therapies based on fundamental external stimuli light, heat, electricity, radiation, or microwaves. Recent efforts have suggested that mechanical stimuli-driven therapy (henceforth referred "mechanical therapy") could provide a direct effect intelligent control augment other anti-cancer systems synergistic combinational treatment. This review article highlights latest advances in present novel perspective principles ultrasound- field-mediated forces, including compression, tension, shear force, torque, can be generated cellular microenvironment using stimuli-activated functional materials. Additionally, this will shed light inspire future research pursue development magnetic-field-activated materials their applications field.

Language: Английский

Citations

67

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation DOI
Haonan Li, Qiang Luo, Hu Zhang

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 47 - 96

Published: Nov. 25, 2022

This review overviews the landscape of nanomedicine-aided cancer radio-immunotherapy in a “from bench to clinic” manner.

Language: Английский

Citations

51

A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair DOI Creative Commons
Bing Xia, Xue Gao,

Jiaqi Qian

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Sept. 1, 2023

Abstract Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in regenerative medicine because of their cargos abundant bioactive cues. Several strategies are proposed to tune EVs production vitro. However, it remains a challenge for manipulation vivo, which poses significant difficulties EVs‐based that aim promote tissue regeneration, particularly long‐term treatment diseases like peripheral neuropathy. Herein, superparamagnetic nanocomposite scaffold capable controlling on‐demand is constructed by incorporating polyethyleneglycol/polyethyleneimine modified nanoparticles into polyacrylamide/hyaluronic acid double‐network hydrogel (Mag‐gel). The Mag‐gel highly sensitive rotating magnetic field (RMF), and can act as mechano‐stimulative platform exert micro/nanoscale forces on encapsulated Schwann cells (SCs), an essential glial cell supporting nerve regeneration. By switching the ON/OFF state RMF, scale up local SCs‐derived (SCs‐EVs) both vitro vivo. Further transcriptome sequencing indicates enrichment transcripts favorable axon growth, angiogenesis, inflammatory regulation SCs‐EVs with ultimately results optimized repair Overall, this research provides noninvasive remotely time‐scheduled method fine‐tuning accelerate including nerves.

Language: Английский

Citations

39