Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

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Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 185 - 202

Published: March 5, 2024

Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose multi-functional composite hydrogel engineered overcome such conditions through recruitment and activation macrophages with adapted degradation the hydrogel. The (G-TSrP) is created by combining gelatin methacryloyl (GelMA) nanoparticles (TSrP) composed tannic acid (TA) Sr2+. These are prepared using one-step mineralization process assisted metal-phenolic network formation. G-TSrP exhibits ability eliminate reactive oxygen species direct polarization toward M2 phenotype. It has been observed that liberation TA Sr2+ from actively facilitate up-regulation expression extracellular matrix remodeling genes macrophages, thereby, coordinate vivo G-TSrP. Most significantly, accelerates angiogenesis despite TA's inhibitory properties, which counteracted released Moreover, enhances wound closure under promotes normal tissue formation strong vessel growth. Genetic analysis confirms macrophage-mediated Collectively, these findings pave way for development biomaterials promote creating regenerative environment.

Language: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763

Published: Aug. 17, 2024

Language: Английский

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Advances in covalent organic frameworks for cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215720 - 215720

Published: Feb. 16, 2024

Language: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

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Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

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Mechanical stimuli-driven cancer therapeutics

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 30 - 46

Published: Dec. 13, 2022

Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources, such as ultrasound magnetic fields, is regarded an emerging patient-friendly effective therapeutic strategy to overcome the limitations of conventional cancer therapies based on fundamental external stimuli light, heat, electricity, radiation, or microwaves. Recent efforts have suggested that mechanical stimuli-driven therapy (henceforth referred "mechanical therapy") could provide a direct effect intelligent control augment other anti-cancer systems synergistic combinational treatment. This review article highlights latest advances in present novel perspective principles ultrasound- field-mediated forces, including compression, tension, shear force, torque, can be generated cellular microenvironment using stimuli-activated functional materials. Additionally, this will shed light inspire future research pursue development magnetic-field-activated materials their applications field.

Language: Английский

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Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 47 - 96

Published: Nov. 25, 2022

This review overviews the landscape of nanomedicine-aided cancer radio-immunotherapy in a “from bench to clinic” manner.

Language: Английский

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A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Sept. 1, 2023

Abstract Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in regenerative medicine because of their cargos abundant bioactive cues. Several strategies are proposed to tune EVs production vitro. However, it remains a challenge for manipulation vivo, which poses significant difficulties EVs‐based that aim promote tissue regeneration, particularly long‐term treatment diseases like peripheral neuropathy. Herein, superparamagnetic nanocomposite scaffold capable controlling on‐demand is constructed by incorporating polyethyleneglycol/polyethyleneimine modified nanoparticles into polyacrylamide/hyaluronic acid double‐network hydrogel (Mag‐gel). The Mag‐gel highly sensitive rotating magnetic field (RMF), and can act as mechano‐stimulative platform exert micro/nanoscale forces on encapsulated Schwann cells (SCs), an essential glial cell supporting nerve regeneration. By switching the ON/OFF state RMF, scale up local SCs‐derived (SCs‐EVs) both vitro vivo. Further transcriptome sequencing indicates enrichment transcripts favorable axon growth, angiogenesis, inflammatory regulation SCs‐EVs with ultimately results optimized repair Overall, this research provides noninvasive remotely time‐scheduled method fine‐tuning accelerate including nerves.

Language: Английский

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