Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417

Опубликована: Янв. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Язык: Английский

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Stimuli-responsive ferroptosis for cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(12), С. 3955 - 3972

Опубликована: Янв. 1, 2023

This review highlights recent advances in the utilization of various endogenous and exogenous stimuli to activate nanocarrier-based ferroptosis cancer therapy that can be effective treating conventional drug-resistant tumors.

Язык: Английский

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 976 - 976

Опубликована: Март 17, 2023

Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation study medicine thanks to advancement field material science and nanomedicine. Improved drug delivery systems with proven efficacy fewer side effects made possible. Nanoformulations varied functions are being created using lipids, polymers, inorganic peptide-based nanomedicines. Therefore, thorough knowledge these intelligent nanomedicines is crucial for developing very promising systems. Polymeric micelles often simple make high solubilization characteristics; result, they seem be alternative other nanosystems. Even though recent studies provided an overview polymeric micelles, here we included discussion on “intelligent” from We also summarized state-of-the-art most micellar respect treatments. Additionally, gave significant attention clinical translation potential treatment various cancers.

Язык: Английский

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One-dimensional nanomaterials for cancer therapy and diagnosis

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4488 - 4514

Опубликована: Янв. 1, 2023

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D can be classified according to their shape, such nanorods, nanotubes, nanowires, self-assembled nanochains, etc., have been applied in electronics, photonics, catalysis. The biological characteristics of nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability capture cancer cells, cellular uptake mechanisms, efficient photothermal conversion, material tunability, aided extending potential biomedical applications, particularly therapy diagnosis. This review highlights a novel perspective on emerging diagnosis by introducing definition physicochemical properties, recent advances also proposes unexplored nanomaterial types therapeutic applications nanomaterials. In particular, most significant exciting years, ultrasound-enabled sonodynamic therapy, magnetic field-based bioresponsive intracellular self-assembly situ, discussed along with concepts, piezoelectric nanozyme-based nanomedicine, others.

Язык: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Год журнала: 2023, Номер 32, С. 66 - 97

Опубликована: Сен. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Язык: Английский

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Integrated Bilayer Microneedle Dressing and Triboelectric Nanogenerator for Intelligent Management of Infected Wounds

Advanced Functional Materials, Год журнала: 2024, Номер 34(28)

Опубликована: Фев. 7, 2024

Abstract The integration of real‐time monitoring and on‐demand treatment has substantial potential to accelerate wound healing processes. In this context, versatile bilayer microneedles (MNs) a triboelectric nanogenerator (TENG) are developed as theranostic platform for efficient management. This provides benefits including controlling infection, promoting cell migration proliferation, the capability biochemical sensing. MNs comprise solvable polyvinylpyrrolidone MN (pMN) affixed atop conductive stainless‐steel (sMN). robust sMN penetrates requisite skin depth, while pMN, infused with antibiotics, ensures sustained drug release upon dissolution in interstitial fluids. Concurrently, TENG generates electrical stimulation transmitted site through sMN, contributing accelerated closure. Furthermore, coated silver carbon nanotubes (CNT/Ag/sMN), functions transdermal electrochemical sensor assess state by detecting hydrogen peroxide uric acid. Notably, vivo animal studies have demonstrated that MN‐TENG device not only effectively inhibits bacterial growth expedites but also monitors biomarkers, thereby validating its utility improving infected recovery. Consequently, based strategy fosters advancements diagnostic therapeutic technologies within management related biomedical domains.

Язык: Английский

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2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca²⁺ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 19, 2024

Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.

Язык: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Язык: Английский

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MOF‐Derived Nanoparticles with Enhanced Acoustical Performance for Efficient Mechano‐Sonodynamic Therapy

Advanced Materials, Год журнала: 2024, Номер 36(33)

Опубликована: Июнь 19, 2024

Ultrasound (US) generates toxic reactive oxygen species (ROS) by acting on sonosensitizers for cancer treatment, and the mechanical damage induced cavitation effects under US is equally significant. Therefore, designing a novel sonosensitizer that simultaneously possesses efficient ROS generation enhanced promising. In this study, carbon-doped zinc oxide nanoparticles (C-ZnO) are constructed mechano-sonodynamic therapy. The presence of carbon (C) doping optimizes electronic structure, thereby enhancing triggered US, efficiently inducing tumor cell death. On other hand, high specific surface area porous structure brought about C enable C-ZnO to enhance stress bubbles irradiation, causing severe cells. Under dual sonodynamic therapy (SDT) mediated C-ZnO, excellent anti-tumor efficacy demonstrated both in vitro vivo, along with level biological safety. This first instance utilizing an inorganic nanomaterial achieve simultaneous enhancement production US-induced holds significant importance future development advancing applications treatment.

Язык: Английский

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Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Small, Год журнала: 2024, Номер 20(23)

Опубликована: Янв. 8, 2024

Abstract Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence FBR poses heavy burden on both medical and socioeconomic systems. This review seeks to elucidate protein “fingerprint” implant materials, which generated by physiochemical properties materials themselves. In this review, activity macrophages, formation foreign giant cells (FBGCs), development fibrosis capsules in context are introduced. Additionally, relationship between various elucidated detail, as an overview existing approaches technologies employed alleviate FBR. Finally, significance components (metallic non‐metallic materials), surface CHEMISTRY (charge wettability), physical characteristics (topography, roughness, stiffness) establishing also well documented. conclusion, aims emphasize importance provides current perspectives developing with anti‐FBR properties.

Язык: Английский

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