Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 255, С. 112523 - 112523
Опубликована: Март 11, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215711 - 215711
Опубликована: Фев. 18, 2024
Язык: Английский
Процитировано
17
Chemical Science, Год журнала: 2024, Номер 15(31), С. 12234 - 12257
Опубликована: Янв. 1, 2024
Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.
Язык: Английский
Процитировано
17
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 31, 2024
Язык: Английский
Процитировано
16
Coordination Chemistry Reviews, Год журнала: 2022, Номер 474, С. 214860 - 214860
Опубликована: Окт. 7, 2022
Язык: Английский
Процитировано
64
Nano Today, Год журнала: 2022, Номер 44, С. 101509 - 101509
Опубликована: Май 26, 2022
Язык: Английский
Процитировано
56
Journal of the American Chemical Society, Год журнала: 2022, Номер 144(18), С. 8317 - 8336
Опубликована: Апрель 28, 2022
Ru(II) complexes that undergo photosubstitution reactions from triplet metal-centered (
Язык: Английский
Процитировано
55
Small, Год журнала: 2022, Номер 18(37)
Опубликована: Авг. 15, 2022
Abstract Photodynamic therapy (PDT) of cancers is seriously restricted by tumor hypoxia. In addition to the intrinsic hypoxic microenvironment, continuous photoirradiation further aggravates intratumoral hypoxia, thereby reducing PDT effect significantly. Oxygen‐independent recognized as an efficient approach overcome this issue. Herein, singlet oxygen ( 1 O 2 )‐stored covalent organic framework (COF) nanoparticles loading near‐infrared (NIR) dye cypate, which realize oxygen‐independent production for concurrent photothermal (PTT) and under NIR irradiation, are presented. The cypate‐loading COF prepared using photosensitizers ‐stored molecules via formation Schiff base bonds, followed coverage poly(vinyl pyrrolidone). significantly improve photostability conversion efficiency cypate protecting them from photodegradation irradiation. Upon 660 nm laser produced photosensitizer motifs successfully stored moieties. After intravenous injection accumulation, can generate heat quickly upon 808 irradiation induces release ablate tumors ‐independent PTT/PDT. Accordingly, nanocarriers provide a paradigm develop PTT/PDT precise cancer treatment
Язык: Английский
Процитировано
41
Chemical Engineering Journal, Год журнала: 2022, Номер 448, С. 137604 - 137604
Опубликована: Июнь 23, 2022
Язык: Английский
Процитировано
39
Journal of the American Chemical Society, Год журнала: 2023, Номер 145(21), С. 11633 - 11642
Опубликована: Май 19, 2023
Development of highly efficient near-infrared (NIR)-excited photosensitizers is hampered by the fast nonradiative vibrational relaxation process regulated energy gap law. Here, from fundamental perspective we propose that intermolecular coupling well-designed has potential to facilitate exciton delocalization and hence reduce exciton-vibration coupling, thereby boosting their phototherapeutic efficacy via inhibition pathway. Such conceived NIR-excited metallo-photosensitizers (IrHA1 IrHA2) were prepared studied for experimental validation. The resulting iridium complexes exhibited a little singlet oxygen (1O2) production in monomeric state, but produced substantially enhanced 1O2 generation efficiency benefiting decoupling self-assembly state. Particularly, IrHA2 exhibits an unprecedented high quantum yield 54.9% (FDA-approved NIR dye indocyanine green: ΦΔ = 0.2%) under 808 nm laser irradiation with negligible heat generation, probably attributed suppression vibronic couplings stretching mode acceptor ligand. In phototherapy, IrHA2-NPs biocompatibility low dark toxicity can induce substantial tumor regression 92.9% volume reduction vivo. This self-assembly-induced strategy would offer effective approach design high-performance photosensitizers.
Язык: Английский
Процитировано
38
Asian Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 18(4), С. 100829 - 100829
Опубликована: Июль 1, 2023
Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.
Язык: Английский
Процитировано
37