Inorganic Chemistry,
Год журнала:
2024,
Номер
63(23), С. 10691 - 10704
Опубликована: Май 28, 2024
As
the
main
challenge
of
dental
healthcare,
oral
infectious
diseases
are
highly
associated
with
colonization
pathogenic
microbes.
However,
current
antibacterial
treatments
in
field
stomatology
still
lack
a
facile,
safe,
and
universal
approach.
Herein,
we
report
controllable
synthesis
copper
aluminum-layered
double
hydroxides
(CuAl-LDHs)
high
Fenton-like
catalytic
activity,
which
can
be
utilized
treatment
negligible
side
effects.
Our
strategy
efficiently
avoid
unwanted
doping
other
divalent
metal
ions
Cu-contained
LDHs
result
formation
binary
CuAl-LDHs
crystallinity
purity.
Evidenced
by
experimental
theoretical
results,
exhibit
excellent
ability
toward
·OH
generation
presence
H2O2
hold
strong
affinity
bacteria,
endowing
them
great
sterilization
against
both
Gram-positive
Gram-negative
bacteria.
expected,
these
provide
outstanding
for
mucosal
infection
periodontitis
promoting
wound
healing
remodeling
periodontal
microenvironment.
Moreover,
toxicity
investigation
demonstrates
overall
safety.
Accordingly,
study
not
only
provides
convenient
economic
treating
but
also
extends
development
novel
LDH-based
Fenton
or
reagents
further
biomedical
applications.
Journal of Materiomics,
Год журнала:
2023,
Номер
9(5), С. 930 - 958
Опубликована: Март 31, 2023
Over
the
last
decades,
bone
tissue
engineering
has
increasingly
become
a
research
focus
in
field
of
biomedical
engineering,
which
biomaterials
play
an
important
role
because
they
can
provide
both
biomechanical
support
and
osteogenic
microenvironment
process
regeneration.
Among
these
biomaterials,
two-dimensional
(2D)
nanomaterials
have
recently
attracted
considerable
interest
owing
to
their
fantastic
physicochemical
biological
properties
including
great
biocompatibility,
excellent
capability,
large
specific
surface
area,
outstanding
drug
loading
capacity.
In
this
review,
we
summarize
state-of-the-art
advances
2D
for
engineering.
Firstly,
introduce
most
explored
used
advantages.
We
then
highlight
cutting-edge
such
as
graphene
its
derivatives,
layered
double
hydroxides,
black
phosphorus,
transition
metal
dichalcogenides,
montmorillonite,
hexagonal
boron
nitride,
graphite
phase
carbon
carbonitrides
(MXenes)
Finally,
current
challenges
future
prospects
regeneration
clinical
translation
are
discussed.
National Science Review,
Год журнала:
2024,
Номер
11(5)
Опубликована: Фев. 27, 2024
China's
aging
demographic
poses
a
challenge
for
treating
prevalent
bone
diseases
impacting
life
quality.
As
regeneration
capacity
diminishes
with
age
due
to
cellular
dysfunction
and
inflammation,
advanced
biomaterials-based
approaches
offer
hope
aged
regeneration.
This
review
synthesizes
materiobiology
principles,
focusing
on
biomaterials
that
target
specific
biological
functions
restore
tissue
integrity.
It
covers
strategies
stem
cell
manipulation,
regulation
of
the
inflammatory
microenvironment,
blood
vessel
regeneration,
intervention
in
anabolism
catabolism,
nerve
regulation.
The
also
explores
molecular
mechanisms
underlying
proposes
database-driven
design
process
future
biomaterial
development.
These
insights
may
guide
therapies
other
age-related
conditions,
contributing
pursuit
'healthy
aging'.
National Science Review,
Год журнала:
2024,
Номер
11(9)
Опубликована: Авг. 10, 2024
ABSTRACT
Organ
injuries,
such
as
acute
kidney
injury,
ischemic
stroke,
and
spinal
cord
often
result
in
complications
that
can
be
life-threatening
or
even
fatal.
Recently,
many
nanomaterials
have
emerged
promising
agents
for
repairing
various
organ
injuries.
In
this
review,
we
present
the
important
developments
field
of
nanomaterial-based
repair
medicine,
herein
referred
to
‘nanorepair
medicine’.
We
first
introduce
disease
characteristics
associated
with
different
types
injuries
highlight
key
examples
relevant
nanorepair
medicine.
then
provide
a
summary
existing
strategies
including
organ-targeting
methodologies
potential
countermeasures
against
exogenous
endogenous
pathologic
risk
factors.
Finally,
offer
our
perspectives
on
current
challenges
future
expectations
advancement
nanomedicine
designed
injury
repair.
Abstract
Two‐dimensional
(2D)
nanomaterials,
known
for
their
unique
atomic
arrangements
and
exceptional
physicochemical
properties,
have
garnered
significant
attention
in
biomedical
applications,
particularly
the
realms
of
immunotherapy
tissue
engineering
tumor
therapy.
These
applications
necessitate
a
thorough
assessment
potential
influence
2D
nanomaterials
on
immune
cells.
Notably,
mononuclear
phagocyte
system
(MPS)
cells,
which
play
pivotal
roles
both
innate
adaptive
immunity,
are
essential
maintaining
organismal
homeostasis.
MPS
cells
with
phagocytic
capability
contribute
to
prevention
foreign
body
invasion
elimination
dead
or
senescent
Furthermore,
including
macrophages
dendritic
serve
as
vital
bridges
between
responses.
Therefore,
understanding
nano‐bio
interactions
is
imperative.
cellular
uptake,
cytocompatibility,
immunological
impact
invaluable
purposeful
design
nanomaterials.
Herein,
we
provide
an
overview
latest
advancements
discuss
current
challenges
future
prospects
employing
field
nanomedicine.
ACS Nano,
Год журнала:
2024,
Номер
18(11), С. 8143 - 8156
Опубликована: Март 4, 2024
The
complexity
and
heterogeneity
of
individual
tumors
have
hindered
the
efficacy
existing
therapeutic
cancer
vaccines,
sparking
intensive
interest
in
development
more
effective
situ
vaccines.
Herein,
we
introduce
a
nanovaccine
for
reactive
oxygen
species-augmented
metalloimmunotherapy
which
FeAl-layered
double
hydroxide
(LDH)
is
used
as
delivery
vehicle
with
dihydroartemisinin
(DHA)
cargo.
LDH
framework
acid-labile
can
be
degraded
tumor
microenvironment,
releasing
iron
ions,
aluminum
DHA.
ions
contribute
to
aggravated
intratumoral
oxidative
stress
injury
by
synergistic
Fenton
reaction
DHA
activation,
causing
apoptosis,
ferroptosis,
immunogenic
cell
death
cells.
subsequently
released
tumor-associated
antigens
adjuvant
form
generate
robust
long-term
immune
responses
against
recurrence
metastasis.
Moreover,
Fe
ion-enabled
T1-weighted
magnetic
resonance
imaging
facilitate
real-time
therapy
monitoring.
This
cancer-nanovaccine-mediated
strategy
has
potential
revolutionizing
precision
immunotherapy
landscape.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 3, 2022
The
discovery
of
a
potent
photosensitizer
with
desirable
immunogenic
cell
death
(ICD)
ability
can
prominently
enhance
antitumor
immunity
in
photodynamic
therapy
(PDT).
However,
majority
commercially-available
photosensitizers
suffer
from
serious
aggregation
and
fail
to
elicit
sufficient
ICD.
Pyroptosis
as
newly
identified
pattern
for
ICD
generation
is
rarely
disclosed
reported
photosensitizers.
In
addition,
the
excellent
mitochondria-anchored
evokes
prominent
mitochondria
oxidative
stress,
consequently
induces
ICD.Herein,
novel
supramolecular
LDH@ZnPc
reported,
without
complicated
preparation,
but
reveals
pyroptosis-triggered
anchoring
feature.
obtained
through
isolation
ZnPc
using
positive
charged
layered
double
hydroxides
(LDH),
achieved.
More
importantly,
LDH@ZnPc-mediated
PDT
effectively
initiate
gasdermin
D
(GSDMD)-dependent
pyroptosis
tumor
cells.
vitro
vivo
results
verify
robust
inhibition
efficacy,
towards
distant
inhibition.This
study
that
act
an
inducer
simultaneous
enhancing
boosting
immunity.
Abstract
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
featuring
an
abnormal
immune
microenvironment
and
resultant
accumulation
of
hydrogen
ions
(H
+
)
produced
by
activated
osteoclasts
(OCs).
Currently,
clinic
RA
therapy
can
hardly
achieve
sustained
or
efficient
therapeutic
outcomes
due
to
the
failures
in
generating
sufficient
modulation
manipulating
H
that
deteriorates
bone
damage.
Herein,
highly
effective
modulatory
nanocatalytic
platform,
nanoceria‐loaded
magnesium
aluminum
layered
double
hydroxide
(LDH‐CeO
2
),
proposed
for
enhanced
based
on
acid
neutralization
metal
ion
inherent
bioactivity.
Specifically,
mild
alkaline
LDH
initiates
significant
M2
repolarization
macrophages
triggered
elevated
antioxidation
effect
CeO
via
neutralizing
excessive
microenvironment,
thus
resulting
recruitment
regulatory
T
cell
(Treg)
suppressions
helper
17
(Th
17)
plasma
cells.
Moreover,
osteogenic
activity
stimulated
Mg
released
from
LDH,
thereby
promoting
damaged
healing.
The
encouraging
adjuvant‐induced
model
mice
demonstrate
high
feasibility
such
concept,
which
provides
novel
modality
bone‐repairing
effects
inorganic
material.
Advanced Materials,
Год журнала:
2023,
Номер
36(43)
Опубликована: Янв. 14, 2023
The
human
immune
system
is
an
interaction
network
of
biological
processes,
and
its
dysfunction
closely
associated
with
a
wide
array
diseases,
such
as
cancer,
infectious
tissue
damage,
autoimmune
diseases.
Manipulation
the
response
in
desired
controlled
fashion
has
been
regarded
promising
strategy
for
maximizing
immunotherapeutic
efficacy
minimizing
side
effects.
Integration
"smart"
bioresponsive
materials
immunoactive
agents
including
small
molecules,
biomacromolecules,
cells
can
achieve
on-demand
release
at
targeted
sites
to
reduce
overdose-related
toxicity
alleviate
off-target
This
review
highlights
design
principles
discusses
critical
roles
from
recruiting,
housing,
manipulating
evoking
responses.
Challenges
future
directions
perspective
clinical
translation
are
also
discussed.
