Acta Biomaterialia, Год журнала: 2024, Номер 179, С. 13 - 35
Опубликована: Март 16, 2024
Язык: Английский
Journal of Materiomics, Год журнала: 2023, Номер 9(5), С. 930 - 958
Опубликована: Март 31, 2023
Over the last decades, bone tissue engineering has increasingly become a research focus in field of biomedical engineering, which biomaterials play an important role because they can provide both biomechanical support and osteogenic microenvironment process regeneration. Among these biomaterials, two-dimensional (2D) nanomaterials have recently attracted considerable interest owing to their fantastic physicochemical biological properties including great biocompatibility, excellent capability, large specific surface area, outstanding drug loading capacity. In this review, we summarize state-of-the-art advances 2D for engineering. Firstly, introduce most explored used advantages. We then highlight cutting-edge such as graphene its derivatives, layered double hydroxides, black phosphorus, transition metal dichalcogenides, montmorillonite, hexagonal boron nitride, graphite phase carbon carbonitrides (MXenes) Finally, current challenges future prospects regeneration clinical translation are discussed.
Язык: Английский
Процитировано
26
National Science Review, Год журнала: 2024, Номер 11(5)
Опубликована: Фев. 27, 2024
China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope aged regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions restore tissue integrity. It covers strategies stem cell manipulation, regulation of the inflammatory microenvironment, blood vessel regeneration, intervention in anabolism catabolism, nerve regulation. The also explores molecular mechanisms underlying proposes database-driven design process future biomaterial development. These insights may guide therapies other age-related conditions, contributing pursuit 'healthy aging'.
Язык: Английский
Процитировано
18
National Science Review, Год журнала: 2024, Номер 11(9)
Опубликована: Авг. 10, 2024
ABSTRACT Organ injuries, such as acute kidney injury, ischemic stroke, and spinal cord often result in complications that can be life-threatening or even fatal. Recently, many nanomaterials have emerged promising agents for repairing various organ injuries. In this review, we present the important developments field of nanomaterial-based repair medicine, herein referred to ‘nanorepair medicine’. We first introduce disease characteristics associated with different types injuries highlight key examples relevant nanorepair medicine. then provide a summary existing strategies including organ-targeting methodologies potential countermeasures against exogenous endogenous pathologic risk factors. Finally, offer our perspectives on current challenges future expectations advancement nanomedicine designed injury repair.
Язык: Английский
Процитировано
15
BMEMat, Год журнала: 2024, Номер 2(2)
Опубликована: Янв. 10, 2024
Abstract Two‐dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly the realms of immunotherapy tissue engineering tumor therapy. These applications necessitate a thorough assessment potential influence 2D nanomaterials on immune cells. Notably, mononuclear phagocyte system (MPS) cells, which play pivotal roles both innate adaptive immunity, are essential maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to prevention foreign body invasion elimination dead or senescent Furthermore, including macrophages dendritic serve as vital bridges between responses. Therefore, understanding nano‐bio interactions is imperative. cellular uptake, cytocompatibility, immunological impact invaluable purposeful design nanomaterials. Herein, we provide an overview latest advancements discuss current challenges future prospects employing field nanomedicine.
Язык: Английский
Процитировано
14
Bone Research, Год журнала: 2024, Номер 12(1)
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
14
ACS Nano, Год журнала: 2024, Номер 18(11), С. 8143 - 8156
Опубликована: Март 4, 2024
The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA. ions contribute to aggravated intratumoral oxidative stress injury by synergistic Fenton reaction DHA activation, causing apoptosis, ferroptosis, immunogenic cell death cells. subsequently released tumor-associated antigens adjuvant form generate robust long-term immune responses against recurrence metastasis. Moreover, Fe ion-enabled T1-weighted magnetic resonance imaging facilitate real-time therapy monitoring. This cancer-nanovaccine-mediated strategy has potential revolutionizing precision immunotherapy landscape.
Язык: Английский
Процитировано
13
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160833 - 160833
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Дек. 3, 2022
The discovery of a potent photosensitizer with desirable immunogenic cell death (ICD) ability can prominently enhance antitumor immunity in photodynamic therapy (PDT). However, majority commercially-available photosensitizers suffer from serious aggregation and fail to elicit sufficient ICD. Pyroptosis as newly identified pattern for ICD generation is rarely disclosed reported photosensitizers. In addition, the excellent mitochondria-anchored evokes prominent mitochondria oxidative stress, consequently induces ICD.Herein, novel supramolecular LDH@ZnPc reported, without complicated preparation, but reveals pyroptosis-triggered anchoring feature. obtained through isolation ZnPc using positive charged layered double hydroxides (LDH), achieved. More importantly, LDH@ZnPc-mediated PDT effectively initiate gasdermin D (GSDMD)-dependent pyroptosis tumor cells. vitro vivo results verify robust inhibition efficacy, towards distant inhibition.This study that act an inducer simultaneous enhancing boosting immunity.
Язык: Английский
Процитировано
32
Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 188, С. 114451 - 114451
Опубликована: Июль 16, 2022
Язык: Английский
Процитировано
31
Advanced Science, Год журнала: 2023, Номер 11(6)
Опубликована: Дек. 8, 2023
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease featuring an abnormal immune microenvironment and resultant accumulation of hydrogen ions (H + ) produced by activated osteoclasts (OCs). Currently, clinic RA therapy can hardly achieve sustained or efficient therapeutic outcomes due to the failures in generating sufficient modulation manipulating H that deteriorates bone damage. Herein, highly effective modulatory nanocatalytic platform, nanoceria‐loaded magnesium aluminum layered double hydroxide (LDH‐CeO 2 ), proposed for enhanced based on acid neutralization metal ion inherent bioactivity. Specifically, mild alkaline LDH initiates significant M2 repolarization macrophages triggered elevated antioxidation effect CeO via neutralizing excessive microenvironment, thus resulting recruitment regulatory T cell (Treg) suppressions helper 17 (Th 17) plasma cells. Moreover, osteogenic activity stimulated Mg released from LDH, thereby promoting damaged healing. The encouraging adjuvant‐induced model mice demonstrate high feasibility such concept, which provides novel modality bone‐repairing effects inorganic material.
Язык: Английский
Процитировано
23