Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 17, 2023

Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.

Language: Английский

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Recent advances in two-dimensional nanomaterials for bone tissue engineering

Journal of Materiomics, Journal Year: 2023, Volume and Issue: 9(5), P. 930 - 958

Published: March 31, 2023

Over the last decades, bone tissue engineering has increasingly become a research focus in field of biomedical engineering, which biomaterials play an important role because they can provide both biomechanical support and osteogenic microenvironment process regeneration. Among these biomaterials, two-dimensional (2D) nanomaterials have recently attracted considerable interest owing to their fantastic physicochemical biological properties including great biocompatibility, excellent capability, large specific surface area, outstanding drug loading capacity. In this review, we summarize state-of-the-art advances 2D for engineering. Firstly, introduce most explored used advantages. We then highlight cutting-edge such as graphene its derivatives, layered double hydroxides, black phosphorus, transition metal dichalcogenides, montmorillonite, hexagonal boron nitride, graphite phase carbon carbonitrides (MXenes) Finally, current challenges future prospects regeneration clinical translation are discussed.

Language: Английский

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Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

BMEMat, Journal Year: 2024, Volume and Issue: 2(2)

Published: Jan. 10, 2024

Abstract Two‐dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly the realms of immunotherapy tissue engineering tumor therapy. These applications necessitate a thorough assessment potential influence 2D nanomaterials on immune cells. Notably, mononuclear phagocyte system (MPS) cells, which play pivotal roles both innate adaptive immunity, are essential maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to prevention foreign body invasion elimination dead or senescent Furthermore, including macrophages dendritic serve as vital bridges between responses. Therefore, understanding nano‐bio interactions is imperative. cellular uptake, cytocompatibility, immunological impact invaluable purposeful design nanomaterials. Herein, we provide an overview latest advancements discuss current challenges future prospects employing field nanomedicine.

Language: Английский

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Bone targeted nano-drug and nano-delivery

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 4, 2024

Language: Английский

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Nanorepair medicine for treatment of organ injury

National Science Review, Journal Year: 2024, Volume and Issue: 11(9)

Published: Aug. 10, 2024

ABSTRACT Organ injuries, such as acute kidney injury, ischemic stroke, and spinal cord often result in complications that can be life-threatening or even fatal. Recently, many nanomaterials have emerged promising agents for repairing various organ injuries. In this review, we present the important developments field of nanomaterial-based repair medicine, herein referred to ‘nanorepair medicine’. We first introduce disease characteristics associated with different types injuries highlight key examples relevant nanorepair medicine. then provide a summary existing strategies including organ-targeting methodologies potential countermeasures against exogenous endogenous pathologic risk factors. Finally, offer our perspectives on current challenges future expectations advancement nanomedicine designed injury repair.

Language: Английский

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A Cancer Nanovaccine Based on an FeAl-Layered Double Hydroxide Framework for Reactive Oxygen Species-Augmented Metalloimmunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8143 - 8156

Published: March 4, 2024

The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA. ions contribute to aggravated intratumoral oxidative stress injury by synergistic Fenton reaction DHA activation, causing apoptosis, ferroptosis, immunogenic cell death cells. subsequently released tumor-associated antigens adjuvant form generate robust long-term immune responses against recurrence metastasis. Moreover, Fe ion-enabled T1-weighted magnetic resonance imaging facilitate real-time therapy monitoring. This cancer-nanovaccine-mediated strategy has potential revolutionizing precision immunotherapy landscape.

Language: Английский

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Harnessing extracellular vesicles from Lactobacillus reuteri and Lactobacillus paracasei for synergistic osteoporosis therapy

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112255 - 112255

Published: Feb. 1, 2025

Language: Английский

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Combination of an LDH-based platform with microRNA for the treatment of myocardial Ischemia-Reperfusion injury by pyroptosis inhibition via the CaSR/PLCγ1/IP3R pathway

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160833 - 160833

Published: Feb. 1, 2025

Language: Английский

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Nanocomposite hydrogels optimize the microenvironment by exterior/interior crosstalk for reprogramming osteoporotic homeostasis in bone defect healing

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 976 - 993

Published: Feb. 22, 2025

Language: Английский

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A mitochondria-anchored supramolecular photosensitizer as a pyroptosis inducer for potent photodynamic therapy and enhanced antitumor immunity

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Dec. 3, 2022

The discovery of a potent photosensitizer with desirable immunogenic cell death (ICD) ability can prominently enhance antitumor immunity in photodynamic therapy (PDT). However, majority commercially-available photosensitizers suffer from serious aggregation and fail to elicit sufficient ICD. Pyroptosis as newly identified pattern for ICD generation is rarely disclosed reported photosensitizers. In addition, the excellent mitochondria-anchored evokes prominent mitochondria oxidative stress, consequently induces ICD.Herein, novel supramolecular LDH@ZnPc reported, without complicated preparation, but reveals pyroptosis-triggered anchoring feature. obtained through isolation ZnPc using positive charged layered double hydroxides (LDH), achieved. More importantly, LDH@ZnPc-mediated PDT effectively initiate gasdermin D (GSDMD)-dependent pyroptosis tumor cells. vitro vivo results verify robust inhibition efficacy, towards distant inhibition.This study that act an inducer simultaneous enhancing boosting immunity.

Language: Английский

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