Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(14)

Опубликована: Фев. 12, 2024

Abstract The fabrication of a multimodal phototheranostic platform on the basis single‐component theranostic agent to afford both imaging and therapy simultaneously, is attractive yet full challenges. emergence aggregation‐induced emission luminogens (AIEgens), particularly those emit fluorescence in second near‐infrared window (NIR‐II), provides powerful tool for cancer treatment by virtue adjustable pathway radiative/non‐radiative energy consumption, deeper penetration depth aggregation‐enhanced performance. Although bulky thiophene π‐bridges such as ortho ‐alkylated thiophene, 3,4‐ethoxylene dioxythiophene benzo[ c ]thiophene are commonly adopted construct NIR‐II AIEgens, subtle differentiation their behaviours has be comprehensively investigated. In this work, systematical investigations discovered that AIEgen BT‐NS bearing possesses acceptable intensity, efficient reactive oxygen species generation, high photothermal conversion efficiency. Eventually, using nanoparticles, unprecedented performance fluorescence/photoacoustic/photothermal imaging‐guided synergistic photodynamic/photothermal elimination tumors was demonstrated. This study thus offers useful insights into developing versatile systems clinical trials.

Язык: Английский

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An All‐Rounder for NIR‐II Phototheranostics: Well‐Tailored 1064 nm‐Excitable Molecule for Photothermal Combating of Orthotopic Breast Cancer

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(26)

Опубликована: Апрель 19, 2024

The second near-infrared (NIR-II, 1000-1700 nm) light-activated organic photothermal agent that synchronously enables satisfying NIR-II fluorescence imaging is highly warranted yet rather challenging on the basis of overwhelming nonradiative decay. Herein, such an agent, namely TPABT-TD, was tactfully designed and constructed via employing benzo[c]thiophene moiety as bulky electron donor/π-bridge tailoring peripheral molecular rotors. Benefitting from its high donor-acceptor strength finely modulated intramolecular motion, TPABT-TD simultaneously exhibits ultralong absorption in region, intense emission NIR-IIa (1300-1500 region nanoaggregates, conversion upon 1064 nm laser irradiation. Those intrinsic advantages endow nanoparticles with prominent fluorescence/photoacoustic/photothermal trimodal imaging-guided therapy against orthotopic 4T1 breast tumor negligible adverse effect.

Язык: Английский

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Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Язык: Английский

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Functional probes for the diagnosis and treatment of infectious diseases

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Июнь 25, 2024

Abstract Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for research treatment of infectious diseases. Their applications in realm include pathogen detection, exploration biological mechanisms, development anti‐infective drugs. This review provides a concise introduction severity, classification, pathogenesis Subsequently, we examined distinctiveness design strategies diagnosing treating diseases, shedding light on their rationale using typical examples. We discuss current status associated with clinical implementation probes. Furthermore, explored prospects these diagnosis aims offer novel insights into diagnostic broaden disease treatment.

Язык: Английский

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Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Язык: Английский

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Elaborated Bio‐Heterojunction With Robust Sterilization Effect for Infected Tissue Regeneration via Activating Competent Cell‐Like Antibacterial Tactic

Advanced Materials, Год журнала: 2024, Номер 36(48)

Опубликована: Окт. 13, 2024

Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO

Язык: Английский

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Development of D–A–D‐Type NIR‐II Photothermal Agents for Synergistic Eradication of Multidrug‐Resistant Bacteria and Promoting Diabetic Wound Healing

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Abstract The challenge in treating diabetic foot infections caused by drug‐resistant bacteria is rapidly eradicating and accelerating wound healing. NIR‐II‐induced photothermal therapy (PTT) offers notable advantages over conventional treatments, such as broad‐spectrum bactericidal efficacy, better penetration depth biological tissues, higher skin tolerance thresholds, making it particularly suitable for addressing infections. Herein, found that NIR‐II dye IR26 exhibited good effects but poor stability. By modifying with methoxy triphenylamine groups, a novel D–A–D‐type small molecule agent (IRC) developed, high stability conversion efficiency (44.3%). IRC maximum absorption wavelength of 1166 nm emission 1238 nm. However, PTT alone cannot effectively promote Therefore, nanoplatforms (Cur‐IRC@PCM) are developed coloading curcumin, natural wound–healing compound, into thermosensitive liposomes to treat MRSA‐infected wounds. Under 980 laser irradiation, Cur‐IRC@PCM provided controlled the precise release synergizing eradicate accelerate closure. intelligent antibacterial also exhibits excellent biocompatibility, rendering promising therapeutic tool biomedical fields combating bacterial

Язык: Английский

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Expanding Our Horizons: AIE Materials in Bacterial Research

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.

Язык: Английский

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Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 22, 2024

Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.

Язык: Английский

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Recent progress of molecular fluorescent probes with multi-recognition sites enable sensitive and selective analysis

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 174, С. 117685 - 117685

Опубликована: Апрель 2, 2024

Язык: Английский

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