Fused‐Ring Pyrrole‐Based Near‐Infrared Emissive Organic RTP Material for Persistent Afterglow Bioimaging

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(5)

Опубликована: Дек. 12, 2023

Organic near-infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing RTP for deep tissue imaging still faces challenges since the small band gap may increase non-radiative decay, resulting weak emission short lifetime. In this study, fused-ring pyrrole-based structures were employed as guest molecules construction of long wavelength emissive materials. Compared decrease singlet energy level, triplet level showed a more effectively with conjugation substituent groups. Moreover, sufficient fused ring molecule suppresses decay excitons. Therefore, material (764 nm) was achieved penetration bioimaging. Tumor cell membrane is used coat nanoparticles (NPs) avoid decreasing performance compared traditional coating by amphiphilic surfactants. NPs tumor-targeting properties show favorable phosphorescent properties, superior stability, excellent biocompatibility. These are applied time-resolved luminescence eliminate interference penetration. This study provides practical solution prepare long-wavelength long-lifetime organic applications

Язык: Английский

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Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Coordination Chemistry Reviews, Год журнала: 2024, Номер 505, С. 215677 - 215677

Опубликована: Янв. 31, 2024

Язык: Английский

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Dual–Acceptor Engineering in Pyrene‐Based Covalent Organic Frameworks for Boosting Photocatalytic Hydrogen Evolution

Advanced Energy Materials, Год журнала: 2024, Номер 14(40)

Опубликована: Июль 18, 2024

Abstract The integration of electron donor (D) and acceptor (A) units into covalent organic frameworks (COFs) has received increasing interest due to its potential for efficient photocatalytic hydrogen (H 2 ) evolution from water. Nevertheless, the advancement D–A COFs is still constrained by limited investigations on engineering, which enables highly effective charge transfer pathways in deliver photoexcited electrons a preferential orientation enhance performance. Herein, two systems with D–A–A configurations based molecular engineering strategy are proposed construct three distinct COFs. Specifically, TAPPy‐DBTDP‐COF merging one pyrene‐based benzothiadiazole acceptors realized an average H rate 12.7 mmol h −1 g under visible light, among highest ever reported typical D–A‐type COF systems. combination experimental theoretical analysis signifies crucial role dual‐acceptor arrangement promoting exciton dissociation carrier migration. These findings underscore significant structural design, conducive separation holes resulting superior activities.

Язык: Английский

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Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Язык: Английский

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2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging

Advanced Functional Materials, Год журнала: 2024, Номер 34(16)

Опубликована: Янв. 4, 2024

Abstract Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration their low biotoxicity, biocompatibility, rapid clearance, good modification properties. As key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role construction donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes research development based on BTD derivatives bioimaging, focusing molecular design photophysical properties, introduces a part applications biological field. Furthermore, challenges BTD‐based future are discussed .

Язык: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122

Опубликована: Авг. 6, 2024

Язык: Английский

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Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Язык: Английский

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The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(2), С. 2010 - 2020

Опубликована: Янв. 7, 2025

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance excited states energy dissipations. In this study, a multifunctional iridium(III) complex exploited by coordination AIE-active N^N ancillary ligand trivalent iridium ion. The resultant DPTPzIr significantly outperforms its parent terms absorption/emission wavelengths, reactive oxygen species (ROS) production, photothermal conversion, which simultaneously endow nanoparticles matched absorption peak to commercial 808 nm laser, longest NIR-II (above 1100 nm) among those previously reported AIE complexes, potentiated type-I ROS generation, as high 60.5% conversion efficiency. Consequently, perform well multimodal image-guided photodynamic therapy-photothermal breast tumor-bearing mice, enabling precise tumor diagnosis complete ablation biocompatibility. Our present work provides simple, feasible, effective paradigm development advanced agents.

Язык: Английский

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Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy cancer immunotherapy. Yet, lack effective strategies induce TLS formation poses substantial obstacle. Thus, exploration potential inducers for is great interest but remains challenging. Here, inspired by mechanism artificially cultivated pearls, covalent organic framework (COF) employed formation. Single-cell sequencing analysis reveals that this achieved promotion cytokine hypersecretion, which facilitates maturation, proliferation, and migration T B cells, critical triggering Furthermore, COF-mediated phototherapy in inducing validated both MC38 4MOSC1 female models. Notably, strong synergistic effect between αCTLA-4 observed, resulting eradication primary distant tumors, while also inhibiting recurrence. boosting immunotherapy, it challenging develop authors report able trigger

Язык: Английский

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Two Key Descriptors for Designing Second Near-Infrared Dyes and Experimental Validation

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(14), С. 9888 - 9896

Опубликована: Март 28, 2024

Second near-infrared (NIR-II) optical imaging technology has emerged as a powerful tool for diagnostic and image-guided surgery due to its higher contrast. However, general strategy efficiently designing NIR-II organic molecules is still lacking, because dyes are usually difficult synthesize, which impeded the rapid development of bioprobes. Herein, based on theoretical calculations 62 multiaryl-pyrrole (MAP) systems with spectra ranging from visible region, continuous red shift toward region could be achieved by adjusting type site substituents MAPs. Two descriptors (ΔEgs μgs) were identified exhibiting strong correlations maximum absorption/emission wavelengths, used predict emission spectrum in only if ΔEgs ≤ 2.5 eV μgs 22.55 D. The experimental absorption ten MAPs fully confirmed predictions, biological vivo newly designed MAP23-BBT showed high spatial resolution deep tissue angiography. More importantly, both have shown applicability most reported donor–acceptor–donor-type non-MAP dyes. These results broad implications efficient design

Язык: Английский

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