Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(23)
Опубликована: Апрель 13, 2023
Abstract
Early
diagnosis
of
allograft
rejection
helps
to
improve
the
immune‐related
management
transplant
recipients.
The
clinically‐used
core
needle
biopsy
method
is
invasive
and
subject
sampling
error.
In
vivo
fluorescence
imaging
for
monitoring
processes
has
advantages
non‐invasiveness,
fast
feedback
high
sensitivity.
Herein,
we
report
a
responsive
second
near‐infrared
(NIR‐II)
fluorescent
nanosensor
(ErGZ)
detect
early
rejection.
ErGZ
allows
ratiometric
in
sensing
granzyme
B,
which
overexpressed
recipients’
T
cells
during
onset
sensor
demonstrates
efficacious
detection
with
sensitivity
specificity,
accomplishes
non‐invasive
skin
deep
buried
islets
mice
models
2
d
5
earlier
than
biopsy,
by
urinary
detection,
respectively,
providing
valuable
approach
therapeutical
management.
Advanced Materials,
Год журнала:
2024,
Номер
36(14)
Опубликована: Янв. 2, 2024
One-for-all
phototheranostics,
referring
to
a
single
component
simultaneously
exhibiting
multiple
optical
imaging
and
therapeutic
modalities,
has
attracted
significant
attention
due
its
excellent
performance
in
cancer
treatment.
Benefitting
from
the
superiority
balancing
diverse
competing
energy
dissipation
pathways,
aggregation-induced
emission
luminogens
(AIEgens)
are
proven
be
ideal
templates
for
constructing
one-for-all
multimodal
phototheranostic
agents.
However,
this
knowledge,
all-round
AIEgens
that
can
triggered
by
second
near-infrared
(NIR-II,
1000-1700
nm)
light
have
not
been
reported.
Given
deep
tissue
penetration
high
maximum
permissible
exposure
of
NIR-II
excitation
light,
herein,
work
reports
first
time
an
laser
excitable
AIE
small
molecule
(named
BETT-2)
with
features
taking
full
use
advantage
molecule-facilitated
versatility
as
well
synchronously
maximizing
molecular
donor-acceptor
strength
conformational
distortion.
As
formulated
into
nanoparticles
(NPs),
BETT-2
NPs
light-driven
fluorescence-photoacoustic-photothermal
trimodal
imaging-guided
photodynamic-photothermal
synergistic
therapy
orthotopic
mouse
breast
tumors
is
fully
demonstrated
systematic
vitro
vivo
evaluations.
This
offers
valuable
insights
developing
activatable
systems.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(13), С. 8991 - 9003
Опубликована: Март 21, 2024
Though
immunogenic
cell
death
(ICD)
has
garnered
significant
attention
in
the
realm
of
anticancer
therapies,
effectively
stimulating
strong
immune
responses
with
minimal
side
effects
deep-seated
tumors
remains
challenging.
Herein,
we
introduce
a
novel
self-assembled
near-infrared-light-activated
ruthenium(II)
metallacycle,
Ru1105
(λem
=
1105
nm),
as
first
example
Ru(II)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
and
reduces
adverse
through
multiple
regulated
approaches,
including
NIR-light
excitation,
increased
reactive
oxygen
species
(ROS)
generation,
selective
targeting
tumor
cells,
precision
organelle
localization,
improved
penetration/retention
capabilities.
Specifically,
demonstrates
excellent
depth-activated
ROS
production
(∼1
cm),
resistance
to
diffusion,
anti-ROS
quenching.
Moreover,
exhibits
promising
results
cellular
uptake
generation
cancer
cells
multicellular
spheroids.
Importantly,
induces
more
efficient
an
ultralow
dose
(10
μM)
compared
conventional
agent,
oxaliplatin
(300
μM).
In
vivo
experiments
further
confirm
Ru1105's
potency
inducer,
eliciting
CD8+
T
depleting
Foxp3+
effects.
Our
research
lays
foundation
for
design
secure
exceptionally
potent
metal-based
agents
immunotherapy.
Chemical Science,
Год журнала:
2023,
Номер
14(11), С. 2901 - 2909
Опубликована: Янв. 1, 2023
Although
metallacycle-based
photosensitizers
have
attracted
increasing
attention
in
biomedicine,
their
clinical
application
has
been
hindered
by
inherent
dark
toxicity
and
unsatisfactory
phototherapeutic
efficiency.
Herein,
we
employ
a
π-expansion
strategy
for
ruthenium
acceptors
to
develop
series
of
Ru(ii)
metallacycles
(Ru1-Ru4),
while
simultaneously
reducing
enhancing
phototoxicity,
thus
obtaining
high
phototoxicity
index
(PI).
These
enable
deep-tissue
(∼7
mm)
fluorescence
imaging
reactive
oxygen
species
(ROS)
production
exhibit
remarkable
anti-tumor
activity
even
under
hypoxic
conditions.
Notably,
Ru4
the
lowest
toxicity,
highest
ROS
generation
ability
an
optimal
PI
(∼146).
Theoretical
calculations
verify
that
exhibits
largest
steric
bulk
singlet-triplet
energy
gap
(ΔEST,
0.62
eV).
In
vivo
studies
confirm
allows
effective
safe
phototherapy
against
A549
tumors.
This
work
is
expected
open
new
avenue
design
high-performance
metal-based
potential
applications.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(14)
Опубликована: Фев. 12, 2024
Abstract
The
fabrication
of
a
multimodal
phototheranostic
platform
on
the
basis
single‐component
theranostic
agent
to
afford
both
imaging
and
therapy
simultaneously,
is
attractive
yet
full
challenges.
emergence
aggregation‐induced
emission
luminogens
(AIEgens),
particularly
those
emit
fluorescence
in
second
near‐infrared
window
(NIR‐II),
provides
powerful
tool
for
cancer
treatment
by
virtue
adjustable
pathway
radiative/non‐radiative
energy
consumption,
deeper
penetration
depth
aggregation‐enhanced
performance.
Although
bulky
thiophene
π‐bridges
such
as
ortho
‐alkylated
thiophene,
3,4‐ethoxylene
dioxythiophene
benzo[
c
]thiophene
are
commonly
adopted
construct
NIR‐II
AIEgens,
subtle
differentiation
their
behaviours
has
be
comprehensively
investigated.
In
this
work,
systematical
investigations
discovered
that
AIEgen
BT‐NS
bearing
possesses
acceptable
intensity,
efficient
reactive
oxygen
species
generation,
high
photothermal
conversion
efficiency.
Eventually,
using
nanoparticles,
unprecedented
performance
fluorescence/photoacoustic/photothermal
imaging‐guided
synergistic
photodynamic/photothermal
elimination
tumors
was
demonstrated.
This
study
thus
offers
useful
insights
into
developing
versatile
systems
clinical
trials.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(6), С. 3167 - 3204
Опубликована: Янв. 1, 2024
We
report
strategies
employed
by
metallacycle/metallacage-based
supramolecular
coordination
complexes
to
enhance
water
solubility
and
biostability
reduce
potential
toxicity
side
effects
for
biomedical
applications.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(26)
Опубликована: Апрель 19, 2024
The
second
near-infrared
(NIR-II,
1000-1700
nm)
light-activated
organic
photothermal
agent
that
synchronously
enables
satisfying
NIR-II
fluorescence
imaging
is
highly
warranted
yet
rather
challenging
on
the
basis
of
overwhelming
nonradiative
decay.
Herein,
such
an
agent,
namely
TPABT-TD,
was
tactfully
designed
and
constructed
via
employing
benzo[c]thiophene
moiety
as
bulky
electron
donor/π-bridge
tailoring
peripheral
molecular
rotors.
Benefitting
from
its
high
donor-acceptor
strength
finely
modulated
intramolecular
motion,
TPABT-TD
simultaneously
exhibits
ultralong
absorption
in
region,
intense
emission
NIR-IIa
(1300-1500
region
nanoaggregates,
conversion
upon
1064
nm
laser
irradiation.
Those
intrinsic
advantages
endow
nanoparticles
with
prominent
fluorescence/photoacoustic/photothermal
trimodal
imaging-guided
therapy
against
orthotopic
4T1
breast
tumor
negligible
adverse
effect.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(32)
Опубликована: Март 22, 2024
Abstract
The
development
of
semiconducting
polymers
(SPs)
with
simultaneous
second
near‐infrared
(NIR‐II)
absorption
and
multimodal
phototheranostic
functions
is
highly
desired
in
the
field
oncotherapy.
Aggregation‐induced
emission
luminogens
(AIEgens)
have
been
acknowledged
to
possess
unique
potential
integrating
multiple
diagnostic
therapeutic
modalities
into
one
organic
molecule.
Nevertheless,
SPs
are
hard
achieve
AIE
activity
due
their
extended
π‐conjugated
skeletons
as
well
large
planar
configuration
commonly‐used
electrophilic
acceptor
moieties.
Herein,
an
ingenious
dimerization‐based
distortion
strategy
proposed
current
work
by
taking
advantage
sterically
encumbered
acceptors
structure
for
successful
construction
AIE‐active
SPs.
Through
further
finely
adjusting
molecular
donor–acceptor
interaction
strength,
obtained
named
SP3
bearing
highest
intramolecular
charge
transfer
effect
presented
NIR‐II
aggregation‐induced
fluorescence
emission,
good
reactive
oxygen
species
production
ability,
superior
photothermal
conversion
performance.
Accordingly,
selected
fabricate
nanoparticles
successfully
applied
laser‐triggered
fluorescence‐photoacoustic
imaging‐guided
photodynamic‐photothermal
therapy
tumors.
This
study
represents
first
excitable
SP,
offers
a
new
perspective
on
designing
advanced
efficient
treatment
malignant
tumor.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
Second
near‐infrared
(NIR‐II)
bioimaging
technology
shows
broad
application
prospects
in
the
field
of
biomedical
due
to
its
significant
superiority
deep
tissue
penetration
and
high
signal‐to‐background
ratio.
Among
them,
organic
small
molecule
fluorophores
have
received
progressively
more
consideration
their
low
biotoxicity,
biocompatibility,
rapid
clearance,
good
modification
properties.
As
key
acceptor
core,
2,
1,
3‐benzothiadiazole
(BTD)
derivative
plays
an
essential
role
construction
donor‐acceptor‐donor
type
NIR‐II
fluorophores.
This
mini‐review
summarizes
research
development
based
on
BTD
derivatives
bioimaging,
focusing
molecular
design
photophysical
properties,
introduces
a
part
applications
biological
field.
Furthermore,
challenges
BTD‐based
future
are
discussed
.