Chemistry of Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Due
to
the
strong
light
trapping
ability,
good
biocompatibility,
and
easily
regulated
molecular
structure,
conjugated
polymers
are
becoming
a
promising
tool
for
phototheranostics
of
tumors,
which
can
achieve
both
precise
diagnosis
efficient
therapeutics.
Of
particular
interest
is
polymer-based
theranostic
agents
applying
second
near-infrared
(NIR-II)
window
(1000–1700
nm),
exhibit
great
potential
clinical
applications
on
account
extremely
long
wavelength.
Herein,
basic
mechanism,
advances
in
recent
6
years,
perspectives
polymer
NIR-II
toward
tumor
discussed
successively.
First,
mechanisms
most
widely
employed
modalities
presented.
In
view
heat
generation
property
under
photoexcitation,
fluorescence
imaging
(FLI)-guided
photothermal
therapy
(PTT)
photoacoustic
(PAI)-guided
PTT.
Then,
related
FLI-guided
PTT
technology,
PAI-guided
multimodel
theranostics
introduced.
Finally,
development
illustrated
practical
application
simultaneously
situ
tumor.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(2), С. 2010 - 2020
Опубликована: Янв. 7, 2025
Developing
small
organic
molecular
phototheranostic
agents
with
second
near-infrared
(NIR-II)
aggregation-induced
emission
(AIE)
is
paramount
for
the
phototriggered
diagnostic
imaging
and
synchronous
in
situ
therapy
of
cancer
via
an
excellent
balance
excited
states
energy
dissipations.
In
this
study,
a
multifunctional
iridium(III)
complex
exploited
by
coordination
AIE-active
N^N
ancillary
ligand
trivalent
iridium
ion.
The
resultant
DPTPzIr
significantly
outperforms
its
parent
terms
absorption/emission
wavelengths,
reactive
oxygen
species
(ROS)
production,
photothermal
conversion,
which
simultaneously
endow
nanoparticles
matched
absorption
peak
to
commercial
808
nm
laser,
longest
NIR-II
(above
1100
nm)
among
those
previously
reported
AIE
complexes,
potentiated
type-I
ROS
generation,
as
high
60.5%
conversion
efficiency.
Consequently,
perform
well
multimodal
image-guided
photodynamic
therapy-photothermal
breast
tumor-bearing
mice,
enabling
precise
tumor
diagnosis
complete
ablation
biocompatibility.
Our
present
work
provides
simple,
feasible,
effective
paradigm
development
advanced
agents.
Advanced Materials,
Год журнала:
2024,
Номер
36(38)
Опубликована: Июль 26, 2024
Abstract
One‐for‐all
phototheranostics
based
on
a
single
molecule
is
recognized
as
convenient
approach
for
cancer
treatment,
whose
efficacy
relies
precise
lesion
localization
through
multimodal
imaging,
coupled
with
the
efficient
exertion
of
phototherapy.
To
unleash
full
potential
phototheranostics,
advancement
in
both
phototheranostic
agents
and
light
delivery
methods
essential.
Herein,
an
integrated
strategy
combining
versatile
featuring
aggregation‐induced
emission,
namely
tBuTTBD,
modified
optical
fiber
to
realize
comprehensive
tumor
diagnosis
“inside‐out”
irradiation
orthotopic
breast
tumor,
proposed
first
time.
Attributed
intense
donor‐acceptor
interaction,
highly
distorted
conformation,
abundant
molecular
rotors,
loose
intermolecular
packing
upon
aggregation,
tBuTTBD
can
synchronously
undergo
second
near‐infrared
(NIR‐II)
fluorescence
photothermal
photodynamic
generation
under
laser
irradiation,
contributing
trimodal
NIR‐II
fluorescence‐photoacoustic
(PA)‐photothermal
imaging‐guided
The
treatment
further
carried
out
following
insertion
fiber,
which
fabricated
by
splicing
flat‐end
air‐core
fiber.
This
configuration
aims
enable
effective
situ
phototherapy
maximizing
energy
utilization
therapeutic
benefits.
work
not
only
enriches
palette
but
also
provides
valuable
insight
exploring
protocol
practical
treatment.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(51)
Опубликована: Авг. 26, 2024
Abstract
Pathogenic
infectious
diseases
have
persistently
posed
significant
threats
to
public
health.
Phototheranostics,
which
combines
the
functions
of
diagnostic
imaging
and
therapy,
presents
an
extremely
promising
solution
block
spread
pathogens
as
well
outbreak
epidemics
owing
its
merits
a
wide‐spectrum
activity,
high
controllability,
non‐invasiveness,
difficult
acquire
resistance.
Among
multifarious
phototheranostic
agents,
second
near‐infrared
(NIR‐II,
1000–1700
nm)
aggregation‐induced
emission
luminogens
(AIEgens)
are
notable
by
virtue
their
deep
penetration
depth,
excellent
biocompatibility,
balanced
radiative
nonradiative
decay
aggregation‐enhanced
theranostic
performance,
making
them
ideal
option
for
combating
pathogens.
This
minireview
provides
systematical
summary
latest
advancements
in
NIR‐II
AIEgens
with
emphasis
on
molecular
design
nanoplatform
formulation
fulfill
high‐efficiency
treating
bacterial
viral
pathogens,
classified
disease
models.
Then,
current
challenges,
potential
opportunities,
future
research
directions
presented
facilitate
further
progress
this
emerging
field.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 23, 2024
Cyanine
dye-containing
nanoparticles
have
widely
been
used
in
"all-in-one"
NIR
fluorescence
imaging
(FI)-guided
photothermal
therapy
(PTT)
because
of
their
intrinsically
large
extinction
coefficient
and
available
physical
chemical
modulation
methods
to
tune
absorption
emission
wavelengths.
The
combination
good
brightness
excellent
tumor-targeting
capacity
is
the
key
realize
efficient
NIR-II
FI-guided
PTT.
In
this
study,
by
covalently
decorating
absorptive
cyanine
dyes
with
bulky
AIE
motify,
we
demonstrate
how
steric
hindrance
suppresses
π-π
stacking-induced
quenching
contributes
FI
subcutaneous
glioblastoma.
resulting
dye
(C12-TPAE)
5
times
brighter
than
original
formulated
liposomal
C12-TPAE-AL
has
a
high
conversion
efficiency
62.4%,
colloidal
light
stability.
Importantly,
ApoE
peptide
absorbed
on
surface,
yielding
lipoprotein-mimicking
nanoparticles,
which
achieve
active
targeting
glioblastoma
PTT
without
tumor
recurrence
any
side
effects
normal
organs
(heart,
kidneys,
liver,
spleen,
or
lung).
This
research
highlights
facile
design
route
for
bright
emissive
indicates
that
biomimetic
theranostic
nanoplatforms
are
promising
candidates
future
precision
therapy.
