Abstract
Exploiting
single
molecular
species
synchronously
affording
powerful
second
near‐infrared
(NIR‐II)
fluorescence,
superior
photoacoustic
output,
prominent
reactive
oxygen
generation,
and
satisfactory
photothermal
conversion
is
supremely
appealing
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
electron
donor/π‐bridge
engineering
implemented
on
the
basis
of
6,7‐di(thiophen‐2‐yl)‐[1,2,5]thiadiazolo[3,4‐
g
]quinoxaline
moiety.
The
optimal
molecule,
namely
TPATO‐TTQ,
demonstrates
to
exhibit
those
notable
features
requested
by
exceptional
which
are
systematically
elucidated
through
depictions
excited‐state
energy
dissipation
pathways
influence
intramolecular
motion
photophysical
properties,
with
assistances
quantum
chemical
calculation
dynamic
simulation.
By
utilizing
TPATO‐TTQ
nanoparticles,
unprecedented
performance
NIR‐II
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐navigated
type
I
photodynamic‐photothermal
synergistic
therapy
orthotopic
breast
cancer
authenticates
precise
tumor
diagnosis
complete
ablation.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(2), С. 2010 - 2020
Опубликована: Янв. 7, 2025
Developing
small
organic
molecular
phototheranostic
agents
with
second
near-infrared
(NIR-II)
aggregation-induced
emission
(AIE)
is
paramount
for
the
phototriggered
diagnostic
imaging
and
synchronous
in
situ
therapy
of
cancer
via
an
excellent
balance
excited
states
energy
dissipations.
In
this
study,
a
multifunctional
iridium(III)
complex
exploited
by
coordination
AIE-active
N^N
ancillary
ligand
trivalent
iridium
ion.
The
resultant
DPTPzIr
significantly
outperforms
its
parent
terms
absorption/emission
wavelengths,
reactive
oxygen
species
(ROS)
production,
photothermal
conversion,
which
simultaneously
endow
nanoparticles
matched
absorption
peak
to
commercial
808
nm
laser,
longest
NIR-II
(above
1100
nm)
among
those
previously
reported
AIE
complexes,
potentiated
type-I
ROS
generation,
as
high
60.5%
conversion
efficiency.
Consequently,
perform
well
multimodal
image-guided
photodynamic
therapy-photothermal
breast
tumor-bearing
mice,
enabling
precise
tumor
diagnosis
complete
ablation
biocompatibility.
Our
present
work
provides
simple,
feasible,
effective
paradigm
development
advanced
agents.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
Advanced Materials,
Год журнала:
2024,
Номер
36(38)
Опубликована: Июль 26, 2024
Abstract
One‐for‐all
phototheranostics
based
on
a
single
molecule
is
recognized
as
convenient
approach
for
cancer
treatment,
whose
efficacy
relies
precise
lesion
localization
through
multimodal
imaging,
coupled
with
the
efficient
exertion
of
phototherapy.
To
unleash
full
potential
phototheranostics,
advancement
in
both
phototheranostic
agents
and
light
delivery
methods
essential.
Herein,
an
integrated
strategy
combining
versatile
featuring
aggregation‐induced
emission,
namely
tBuTTBD,
modified
optical
fiber
to
realize
comprehensive
tumor
diagnosis
“inside‐out”
irradiation
orthotopic
breast
tumor,
proposed
first
time.
Attributed
intense
donor‐acceptor
interaction,
highly
distorted
conformation,
abundant
molecular
rotors,
loose
intermolecular
packing
upon
aggregation,
tBuTTBD
can
synchronously
undergo
second
near‐infrared
(NIR‐II)
fluorescence
photothermal
photodynamic
generation
under
laser
irradiation,
contributing
trimodal
NIR‐II
fluorescence‐photoacoustic
(PA)‐photothermal
imaging‐guided
The
treatment
further
carried
out
following
insertion
fiber,
which
fabricated
by
splicing
flat‐end
air‐core
fiber.
This
configuration
aims
enable
effective
situ
phototherapy
maximizing
energy
utilization
therapeutic
benefits.
work
not
only
enriches
palette
but
also
provides
valuable
insight
exploring
protocol
practical
treatment.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(51)
Опубликована: Авг. 26, 2024
Abstract
Pathogenic
infectious
diseases
have
persistently
posed
significant
threats
to
public
health.
Phototheranostics,
which
combines
the
functions
of
diagnostic
imaging
and
therapy,
presents
an
extremely
promising
solution
block
spread
pathogens
as
well
outbreak
epidemics
owing
its
merits
a
wide‐spectrum
activity,
high
controllability,
non‐invasiveness,
difficult
acquire
resistance.
Among
multifarious
phototheranostic
agents,
second
near‐infrared
(NIR‐II,
1000–1700
nm)
aggregation‐induced
emission
luminogens
(AIEgens)
are
notable
by
virtue
their
deep
penetration
depth,
excellent
biocompatibility,
balanced
radiative
nonradiative
decay
aggregation‐enhanced
theranostic
performance,
making
them
ideal
option
for
combating
pathogens.
This
minireview
provides
systematical
summary
latest
advancements
in
NIR‐II
AIEgens
with
emphasis
on
molecular
design
nanoplatform
formulation
fulfill
high‐efficiency
treating
bacterial
viral
pathogens,
classified
disease
models.
Then,
current
challenges,
potential
opportunities,
future
research
directions
presented
facilitate
further
progress
this
emerging
field.
Chemosensors,
Год журнала:
2025,
Номер
13(2), С. 67 - 67
Опубликована: Фев. 13, 2025
Near-infrared
(NIR)
light
is
a
promising
tool
for
biomedical
imaging
and
therapy,
offering
excellent
tissue
penetration,
low
scattering,
minimal
biological
fluorescence
interference.
An
NIR-II
optical
range
of
900–1880
nm
with
reduced
background
interference
particularly
useful
disease
diagnosis
treatment.
Probes
based
on
organic
molecules
are
gaining
attention
their
structural
flexibility
stable
performance.
Organic
molecular
aggregates,
such
as
J-aggregates,
H-aggregates,
aggregation-induced
emission
(AIE)-aggregates,
exhibit
unique
properties
like
tunable
spectral
shifts,
improved
photostability,
higher
absorption
quantum
yields.
This
mini
review
briefly
discusses
the
advancements
in
therapy
technologies,
focusing
classification,
formation
mechanisms,
applications
aggregates
treatment,
theoretical
foundation
practical
guidance
future
research.
