Nanoscale, Год журнала: 2023, Номер 15(38), С. 15472 - 15512
Опубликована: Янв. 1, 2023
Hydrophilic antifouling polymers are important materials for nanomedicine and surface modification applications. In this review, we discuss their structures, properties, function in the context of recent nanoscale
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(33)
Опубликована: Июнь 14, 2024
Abstract Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing inherent activity based on ε‐polylysine a poly(ethylene glycol) derivative is developed. The engineered exhibits rapid gelation behavior, high mechanical strength, strong various tissues, can sustain ultrahigh burst pressure 450 mmHg. It also presents excellent biocompatibility, biodegradability, properties, on‐demand removability. Significantly improved hemostatic efficacy gel compared fibrin glue demonstrated using injury models in rats rabbits. Remarkably, the effectively halt lethal non‐compressible hemorrhages visceral organs (liver, spleen, heart) femoral artery fully anticoagulated pigs. Furthermore, outperforms commercial products sutureless closure repair rat liver defect, skin incision, infected full‐thickness models. Overall, this study highlights promising clinical applications managing uncontrolled hemorrhage, closure, repair.
Язык: Английский
Процитировано
41
MedComm – Oncology, Год журнала: 2024, Номер 3(1)
Опубликована: Март 1, 2024
Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding
Язык: Английский
Процитировано
31
Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133800 - 133800
Опубликована: Фев. 15, 2024
Язык: Английский
Процитировано
25
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 259, С. 129233 - 129233
Опубликована: Янв. 4, 2024
Язык: Английский
Процитировано
19
Biomacromolecules, Год журнала: 2024, Номер 25(2), С. 541 - 563
Опубликована: Янв. 19, 2024
Nanoformulation of active payloads or pharmaceutical ingredients (APIs) has always been an area interest to achieve targeted, sustained, and efficacious delivery. Various delivery platforms have explored, but loading APIs challenging because the chemical structural properties these molecules. Polymersomes made from amphiphilic block copolymers (ABCPs) shown enormous promise as a tunable API platform confer multifold advantages over lipid-based systems. For example, COVID booster vaccine comprising polymersomes encapsulating spike protein (ACM-001) recently completed Phase I clinical trial provides case for developing safe drug products based on ABCP platforms. However, several limitations need be resolved before they can reach their full potential. In this Perspective, we would like highlight such aspects requiring further development translating ABCP-based proof concept viable commercial product.
Язык: Английский
Процитировано
18
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.
Язык: Английский
Процитировано
2
Chemistry of Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)
Опубликована: Авг. 4, 2023
Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting
Язык: Английский
Процитировано
36
Biomaterials, Год журнала: 2023, Номер 295, С. 122028 - 122028
Опубликована: Янв. 30, 2023
Язык: Английский
Процитировано
31
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(30)
Опубликована: Май 26, 2023
Abstract Amphiphilic self‐immolative polymers (SIPs) can achieve complete degradation solely through one triggerable event, which potentially optimize the blood clearance and uncontrollable/inert degradability for therapeutic nanoparticles. Herein, we report amphiphilic poly(ferrocenes), BP nbs ‐Fc , composed by backbone aminoferrocene (AFc) side chains as well end‐capping poly(ethylene glycol) monomethyl ether. Upon triggering tumor acidic milieu, nanoparticles readily degrade to release azaquinone methide (AQM) moieties, rapidly deplete intracellular glutathione (GSH) cascade AFc. Furthermore, both AFc its product Fe 2+ catalyze hydrogen peroxide (H 2 O ) into highly reactive hydroxyl radicals (⋅OH), thus amplifying oxidative stress of cells. Rational synergy GSH depletion ⋅OH burst efficiently inhibit growth SIPs in vitro vivo. This work provides an elegant design adopt innate milieu‐triggerable boost cellular stress, is a promising candidate precision medicine.
Язык: Английский
Процитировано
27