ABSTRACT
Cancer
research
predominantly
centers
on
diagnosis,
treatment,
and
elucidation
of
underlying
mechanisms.
Nevertheless,
the
intricate
nature
tumor
genesis
development
has
rendered
early
diagnostic
therapeutic
outcomes
less
than
optimal,
making
conquest
a
formidable
challenge.
The
interdisciplinary
fusion
medicine
engineering,
termed
“intersection
engineering”,
emerged
as
groundbreaking
paradigm,
offering
novel
avenues
for
advancing
cancer
studies.
As
this
approach
evolves,
it
yielded
numerous
breakthroughs
in
mechanistic
exploration.
In
review,
we
summarize
how
intersection
engineering
propels
progress
by
leveraging
combined
strengths
medicine,
bioinformatics,
materials
science,
artificial
intelligence.
This
addresses
limitations
traditional
diagnostics
therapies,
such
low
sensitivity,
poor
efficacy,
significant
side
effects,
challenges
associated
with
Moreover,
highlight
global
cutting‐edge
advancements
potential
future
directions
field.
Organic Letters,
Год журнала:
2023,
Номер
25(42), С. 7650 - 7655
Опубликована: Окт. 13, 2023
By
taking
advantage
of
their
strong
absorption
ability,
visible-light-induced
direct
photoamination
BODIPY
dyes
with
aqueous
ammonia
was
developed
to
give
structurally
diverse
α-amino
BODIPYs.
The
excited
state
BODIPYs
possessed
higher
electron
affinity
than
the
ground
and
thus
showed
largely
enhanced
reactivity
toward
weak
nucleophile
ammonia.
Those
are
valuable
synthetic
intermediates
have
been
successfully
demonstrated
in
several
post-transformation
reactions.
work
indicates
that
photoreaction
is
an
excellent
alternative
conventional
functionalization
this
popular
fluorophore.
Abstract
Hypoxic
tumor
microenvironments
pose
significant
challenges
to
the
clinical
translation
of
cancer
photodynamic
therapy
(PDT).
While
heavy
atom‐free
Type‐I
boron
dipyrromethenes
(BODIPYs)
photosensitizers
can
alleviate
this
challenge
by
reducing
oxygen
dependency,
but
they
remain
scarce.
Herein,
heavy‐atom‐free
α,meso
‐linked
bisBODIPYs
were
designed
and
synthesized.
These
exhibit
remarkable
red‐shifted
emission
(λemmax
~670
nm),
large
Stokes
shifts
(~4480
cm
−1
)
are
capable
producing
both
superoxide
anion
(O
2
⋅
−
singlet
(
1
O
in
solution
cells.
Additionally,
offer
a
wide
PDT
treatment
window,
ranging
from
0.26
83.5
μM.
Furthermore,
these
also
demonstrate
superior
two‐photon
fluorescence,
promising
for
surgical
navigation
integrating
diagnosis
with
treatment.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(41)
Опубликована: Июль 24, 2024
Abstract
Synthesis
of
BODIPY
oligomers
has
attracted
increasing
attention
due
to
their
intriguing
properties
and
promising
applications.
Significant
progress
been
made
synthesize
via
post‐functionalization,
either
single‐bond
linked
or
fully
conjugated.
This
concept
article
highlights
the
recent
developments
oligomers,
including
synthetic
routes,
photophysical
applications
in
areas
NIR
light
absorbing
dye,
photodynamic
therapy,
bioimaging
etc.
ABSTRACT
Cancer
research
predominantly
centers
on
diagnosis,
treatment,
and
elucidation
of
underlying
mechanisms.
Nevertheless,
the
intricate
nature
tumor
genesis
development
has
rendered
early
diagnostic
therapeutic
outcomes
less
than
optimal,
making
conquest
a
formidable
challenge.
The
interdisciplinary
fusion
medicine
engineering,
termed
“intersection
engineering”,
emerged
as
groundbreaking
paradigm,
offering
novel
avenues
for
advancing
cancer
studies.
As
this
approach
evolves,
it
yielded
numerous
breakthroughs
in
mechanistic
exploration.
In
review,
we
summarize
how
intersection
engineering
propels
progress
by
leveraging
combined
strengths
medicine,
bioinformatics,
materials
science,
artificial
intelligence.
This
addresses
limitations
traditional
diagnostics
therapies,
such
low
sensitivity,
poor
efficacy,
significant
side
effects,
challenges
associated
with
Moreover,
highlight
global
cutting‐edge
advancements
potential
future
directions
field.
