Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(45), P. 8150 - 8155
Published: Nov. 3, 2023
Through
a
strong
oxidant
Pb(OAc)4
promoted
oxidative
nucleophilic
hydrogen
substitution,
site-selective
direct
and
stepwise
cyanation
of
BODIPYs
using
tetrabutylammonium
cyanide
was
developed
to
give
α-cyanated
BODIPY
derivatives.
Characterization
optical
electrochemical
properties
these
dyes
provides
substantial
enhancement
the
electron
affinity,
with
reduction
potential
LUMO
level
as
low
-0.04
V
-4.43
eV,
respectively.
Radical
anions
electron-deficient
3,5-dicyanated
were
characterized
by
absorption
EPR
spectroscopy.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Aromatic
systems
with
bridged
sulfur
units
in
varying
oxidation
states
have
enabled
photoresponsive
materials
for
anticounterfeiting
and
supramolecular
assembly.
However,
only
a
few
sulfoxide-bridged
chromophores
exhibit
photoinduced
extrusion,
leading
to
drastic
photophysical
changes
that
make
them
useful
as
stimuli-responsive
materials.
Here,
we
present
nitrogen-substituted
anthracene
(aza-anthracene)
bridge
different
states.
Overall,
aza-anthracene
produces
red-shifted
green-to-red
similar
sulfoxide
photoconversion
behavior
compared
the
analog.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 28, 2025
Single-molecule
localization
microscopy
(SMLM)
provides
precise,
high-resolution
visualization
of
target
biomolecules
in
cellular
imaging.
Fluorescent
light-up
aptamers
(FLAPs)
offer
a
versatile
approach
for
labeling
RNA
interest
live
cells
by
binding
to
fluorogens
through
adaptive
recognition.
Several
FLAPs
can
generate
blinking
fluorescent
signals
conjunction
with
fluorogens,
enabling
single-molecule
imaging
living
cells.
An
example
this
is
RhoBAST,
which
has
been
successfully
used
due
its
fast
exchange
kinetics
fluorogens.
However,
activities
regulated
proteins
presents
greater
challenge.
Here,
we
introduce
mDZ-RhoBAST,
nucleic
acid
probe,
visualize
the
demethylation
process
fat
mass
and
obesity-associated
protein
(FTO)
This
probe
combines
6mA-modified
DNAzyme
RhoBAST
FLAP,
activated
FTO,
restoring
DNAzyme's
cleavage
activity
releasing
bind
fluorogen.
Our
achieved
super-resolution
endogenous
providing
real-time
insights
into
processes
vivo.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(42), P. 7650 - 7655
Published: Oct. 13, 2023
By
taking
advantage
of
their
strong
absorption
ability,
visible-light-induced
direct
photoamination
BODIPY
dyes
with
aqueous
ammonia
was
developed
to
give
structurally
diverse
α-amino
BODIPYs.
The
excited
state
BODIPYs
possessed
higher
electron
affinity
than
the
ground
and
thus
showed
largely
enhanced
reactivity
toward
weak
nucleophile
ammonia.
Those
are
valuable
synthetic
intermediates
have
been
successfully
demonstrated
in
several
post-transformation
reactions.
work
indicates
that
photoreaction
is
an
excellent
alternative
conventional
functionalization
this
popular
fluorophore.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(20)
Published: Jan. 31, 2023
Dual-emissive
photoconvertible
fluorophores
(DPCFs)
are
powerful
tools
to
unambiguously
track
labeled
cells
in
bioimaging.
We
recently
introduced
a
new
rational
mechanism
called
directed
photooxidation-induced
conversion
(DPIC)
enabling
efficient
DPCFs
be
obtained
by
conjugating
coumarin
aromatic
singlet-oxygen
reactive
moieties
(ASORMs).
Pyrrole
was
found
suitable
ASORM
as
it
provided
high
hypsochromic
shift
along
with
fast
and
conversion.
By
synthesizing
various
pyrrole-based
styryl
dyes,
we
showed
that
the
photoconversion
properties,
including
quantum
yield
of
chemical
can
tuned
modification
pyrrole.
These
modifications
led
an
improved
dual
emissive
converter,
SCP-Boc,
which
displayed
brightness
enhanced
63
%.
SCP-Boc
successfully
used
sequentially
photoconvert
laser
scanning
confocal
microscopy.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(45), P. 8150 - 8155
Published: Nov. 3, 2023
Through
a
strong
oxidant
Pb(OAc)4
promoted
oxidative
nucleophilic
hydrogen
substitution,
site-selective
direct
and
stepwise
cyanation
of
BODIPYs
using
tetrabutylammonium
cyanide
was
developed
to
give
α-cyanated
BODIPY
derivatives.
Characterization
optical
electrochemical
properties
these
dyes
provides
substantial
enhancement
the
electron
affinity,
with
reduction
potential
LUMO
level
as
low
-0.04
V
-4.43
eV,
respectively.
Radical
anions
electron-deficient
3,5-dicyanated
were
characterized
by
absorption
EPR
spectroscopy.
