Polyphenol‐Copper Derived Self‐Cascade Nanozyme Hydrogel in Boosting Oxygenation and Robust Revascularization for Tissue Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер 34(40)

Опубликована: Апрель 25, 2024

Abstract The regeneration of hypoxia‐impaired chronic tissue defects has long been challenging, mainly due to the inefficiency oxygenation and limited biological activity existing oxygen delivery systems in regulating dynamic process. Herein, a novel polyphenol‐copper coordination strategy fabricate bioactive superoxide dismutase‐catalase self‐cascade nanozymes (SalB‐CuNCs) is reported, which can serve as an situ oxygenator induce angiogenesis simultaneously. copper‐phenolic hydroxyl structure SalB‐CuNCs plays critical role promoting enzyme‐like cascade reaction via catechol‐mediated Cu valence state transition substrate capture mechanism. Furthermore, after incorporating into Schiff base hydrogel (COC@SalB‐Cu), resulting system exhibits outstanding antioxidant robust effect mitigating hypoxic microenvironment. Benefiting from intrinsic angiogenic SalB copper, COC@SalB‐Cu more complete tube formation by up‐regulating expression level vascular endothelial growth factor (VEGF), platelet‐endothelial cell adhesion molecule‐1 (CD31), nitric oxide synthase (eNOS). In vivo experiments further demonstrate that significantly restore blood supply, leading fast regeneration. present holds enormous promise for treatment hypoxia‐related injury field regenerative medicine.

Язык: Английский

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Advances in design and preparation of nanozymes and their applications for constructing higher sensitive lateral flow assays

Coordination Chemistry Reviews, Год журнала: 2024, Номер 510, С. 215797 - 215797

Опубликована: Апрель 4, 2024

Язык: Английский

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Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application

Nanomaterials, Год журнала: 2024, Номер 14(3), С. 244 - 244

Опубликована: Янв. 23, 2024

A nanozyme is a nanoscale material having enzyme-like properties. It exhibits several superior properties, including low preparation cost, robust catalytic activity, and long-term storage at ambient temperatures. Moreover, high stability enables repetitive use in multiple reactions. Hence, it considered potential replacement for natural enzymes. Enormous research interest nanozymes the past two decades has made imperative to look better enzyme-mimicking materials biomedical applications. Given this, on metal–organic frameworks (MOFs) as gained momentum. MOFs are advanced hybrid of inorganic metal ions organic ligands. Their distinct composition, adaptable pore size, structural diversity, ease tunability physicochemical properties enable mimic activities act promising candidates. This review aims discuss recent advances development MOF-based (MOF-NZs) highlight their applications field biomedicine. Firstly, different enzyme-mimetic exhibited by discussed, insights given into various strategies achieve them. Modification functionalization deliberated obtain MOF-NZs with enhanced activity. Subsequently, biosensing therapeutics domain discussed. Finally, concluded giving challenges encountered possible directions overcome them future. With this review, we aim encourage consolidated efforts across enzyme engineering, nanotechnology, science, biomedicine disciplines inspire exciting innovations emerging yet field.

Язык: Английский

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Recent progress of MOF-based antibacterial hydrogels

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150641 - 150641

Опубликована: Март 26, 2024

Язык: Английский

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Beyond conventional: Role of chiral metal–organic frameworks in asymmetric scenarios

Nano Today, Год журнала: 2024, Номер 56, С. 102227 - 102227

Опубликована: Март 18, 2024

Язык: Английский

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