Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 4102 - 4117
Опубликована: Июнь 12, 2024
Tumor
vaccine,
a
promising
modality
of
tumor
immunotherapy,
needs
to
go
through
the
process
antigen
generation
and
loading,
drainage
lymph
nodes
(LNs),
internalization
by
dendritic
cells
(DCs),
DC
maturation,
cross-presentation
activate
T-cells.
However,
vaccines
are
often
unable
satisfy
all
steps,
leading
limitation
their
application
efficacy.
Herein,
based
on
smart
nanogel
system,
an
Abstract
Cancer
immunotherapies
have
improved
human
health,
and
one
among
the
important
technologies
for
cancer
immunotherapy
is
vaccine.
Antigens
are
most
components
in
vaccines.
Generally,
antigens
vaccines
can
be
divided
into
two
categories:
pre‐defined
unidentified
antigens.
Although,
loaded
with
predefined
commonly
used,
vaccine
mixed
antigens,
especially
whole
cells
or
cell
lysates,
a
very
promising
approach,
such
obviate
some
limitations
Their
advantages
include,
but
not
limited
to,
inclusion
of
pan‐spectra
(all
kinds
of)
inducing
pan‐clones
specific
T
cells,
overcoming
heterogeneity
cells.
In
this
review,
recent
advances
based
on
whole‐tumor
either
summarized.
terms
focus
applying
water‐soluble
lysates
as
Recently,
utilizing
has
become
feasible.
Considering
that
pre‐determined
antigen‐based
(mainly
peptide‐based
mRNA‐based)
various
limitations,
developing
alternative.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 10, 2024
Abstract
Covalent
organic
frameworks
(COFs)
attract
significant
attention
due
to
their
ordered,
crystalline,
porous,
metal‐free,
and
predictable
structures.
These
unique
characteristics
offer
great
opportunities
for
the
diffusion
transmission
of
photogenerated
charges
during
photocatalysis.
Currently,
a
considerable
number
COFs
are
used
as
metal‐free
semiconductor
photocatalysts.
This
review
aims
understand
relationships
between
structure
photocatalysis
performance
provides
in‐depth
insight
into
synthetic
strategy
improve
performance.
Subsequently,
focuses
on
structural
motif
in
sustainable
photocatalytic
hydrogen
evolution,
carbon
dioxide
reduction,
peroxide
generation,
compound
transformations.
Last,
conjunction
with
progress
achieved
challenges
yet
be
overcome,
candid
discussion
is
undertaken
regarding
field
COF
photocatalysis,
accompanied
by
presentation
potential
research
avenues
future
directions.
seeks
provide
readers
comprehensive
understanding
pivotal
role
robust
guidance
innovative
utilization
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(5), С. 2643 - 2692
Опубликована: Янв. 1, 2024
This
review
discusses
the
structures
and
engineering
strategies
of
nanocatalysts,
highlighting
their
underlying
mechanisms
applications
in
cancer
immunotherapy.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(12)
Опубликована: Фев. 2, 2024
Abstract
Due
to
the
presence
of
natural
neoantigens,
autologous
tumor
cells
hold
great
promise
as
personalized
therapeutic
vaccines.
Yet
cell
vaccines
require
multi‐step
production
that
frequently
leads
loss
immunoreactive
antigens,
causing
insufficient
immune
activation
and
significantly
hampering
their
clinical
applications.
Herein,
we
introduce
a
novel
whole‐cell
cancer
vaccine
by
cloaking
with
lipopolysaccharide‐decorated
manganese(II)‐phenolic
networks
(MnTA
nanocloaks)
evoke
tumor‐specific
response
for
highly
efficacious
synergistic
immunotherapy.
The
polyphenols
coordinate
Mn
2+
immediately
adhere
surface
individual
cells,
thereby
forming
nanocloak
encapsulating
neoantigens.
Subsequent
decoration
lipopolysaccharide
induces
internalization
dendritic
where
ions
are
released
in
cytosol,
further
facilitating
stimulator
interferon
genes
(STING)
pathway.
Highly
effective
suppression
was
observed
combining
nanocloaked
treatment
anti‐programmed
death
ligand
1
(anti‐PD‐L1)
antibodies‐mediated
checkpoint
blockade
therapy.
Our
work
demonstrates
universal
yet
simple
strategy
engineer
cell‐based
nanobiohybrid
system
enhanced
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 2, 2025
The
discovery
of
tertiary
lymphoid
structures
(TLS)
within
tumor
tissues
provides
a
promising
avenue
to
promote
the
efficacy
cancer
immunotherapy.
Yet,
lack
effective
strategies
induce
TLS
formation
poses
substantial
obstacle.
Thus,
exploration
potential
inducers
for
is
great
interest
but
remains
challenging.
Here,
inspired
by
mechanism
artificially
cultivated
pearls,
covalent
organic
framework
(COF)
employed
formation.
Single-cell
sequencing
analysis
reveals
that
this
achieved
promotion
cytokine
hypersecretion,
which
facilitates
maturation,
proliferation,
and
migration
T
B
cells,
critical
triggering
Furthermore,
COF-mediated
phototherapy
in
inducing
validated
both
MC38
4MOSC1
female
models.
Notably,
strong
synergistic
effect
between
αCTLA-4
observed,
resulting
eradication
primary
distant
tumors,
while
also
inhibiting
recurrence.
boosting
immunotherapy,
it
challenging
develop
authors
report
able
trigger
Abstract
Covalent
organic
frameworks
(COFs),
known
for
their
exceptional
in
situ
encapsulation
and
precise
release
capabilities,
are
emerging
as
pioneering
drug
delivery
systems.
This
study
introduces
a
hypoxia‐responsive
COF
designed
to
encapsulate
the
chemotherapy
gambogic
acid
(GA)
situ.
Bimetallic
gold‐palladium
islands
were
grown
on
UiO‐66‐NH
2
(UiO)
form
UiO@Au‐Pd
(UAPi),
which
encapsulated
with
GA
through
membrane
formation,
resulting
core‐shell
structure
(UAPiGC).
Further
modification
hyaluronic
(HA)
created
@GA‐COF@HA
(UAPiGCH)
enhanced
tumor
targeting.
In
hypoxic
microenvironment,
collapses,
releasing
UAPi,
initiating
triple
therapeutic
response:
nanozyme‐catalyzed
therapy,
near‐infrared
II
(NIR‐II)
mild
photothermal
therapy
(mild‐PTT),
chemotherapy.
UAPi
exhibits
catalase
(CAT)‐like
peroxidase
(POD)‐like
activities,
generating
oxygen
alleviate
hypoxia
reactive
species
(ROS)
destruction.
acts
chemotherapeutic
agent
inhibits
heat
shock
protein
90
(HSP90),
enhancing
sensitivity.
vitro
vivo
studies
confirm
UAPiGCH’s
ability
induce
pyroptosis,
stimulate
dendritic
cell
maturation,
boost
T
infiltration,
demonstrating
its
potential
nanoplatform.
strategy
integrates
multiple
therapies
into
system,
offering
promising
applications
cancer
treatment.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(48), С. 26296 - 26307
Опубликована: Ноя. 21, 2023
Immunotherapy
of
triple-negative
breast
cancer
(TNBC)
has
an
unsatisfactory
therapeutic
outcome
due
to
immunologically
"cold"
microenvironment.
Fusobacterium
nucleatum
(F.
nucleatum)
was
found
be
colonized
in
tumors
and
responsible
for
the
immunosuppressive
tumor
microenvironment
metastasis.
Herein,
we
constructed
a
bacteria-derived
outer
membrane
vesicle
(OMV)-coated
nanoplatform
that
precisely
targeted
tissues
dual
killing
F.
cells,
thus
transforming
intratumor
bacteria
into
immunopotentiators
immunotherapy
TNBC.
The
as-prepared
nanoparticles
efficiently
induced
immunogenic
cell
death
through
Fenton-like
reaction,
resulting
enhanced
immunogenicity.
Meanwhile,
intratumoral
killed
by
metronidazole,
release
pathogen-associated
molecular
patterns
(PAMPs).
PAMPs
cooperated
with
OMVs
further
facilitated
maturation
dendritic
cells
subsequent
T-cell
infiltration.
As
result,
"kill
two
birds
one
stone"
strategy
warmed
up
cold
environment,
maximized
antitumor
immune
response,
achieved
efficient
therapy
TNBC
as
well
metastasis
prevention.
Overall,
this
based
on
microecology
distinction
normal
tissue
microbiome-induced
reversal
provides
new
insight
precise
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(49)
Опубликована: Авг. 7, 2023
Abstract
Bioorthogonal
chemistry
is
a
promising
toolbox
for
dissecting
biological
processes
in
the
native
environment.
Recently,
bioorthogonal
reactions
have
attracted
considerable
attention
medical
field
treating
diseases,
since
this
approach
may
lead
to
improved
drug
efficacy
and
reduced
side
effects
via
situ
synthesis.
For
precise
biomedical
applications,
it
prerequisite
that
should
occur
right
locations
on
appropriate
therapeutic
targets.
In
minireview,
we
highlight
design
development
of
targeted
treatment.
First,
compile
recent
strategies
achieving
target‐specific
reactions.
Further,
emphasize
their
application
treatment
different
Finally,
perspective
provided
challenges
future
directions
emerging
safe,
efficient,
translatable
disease
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(12), С. 8585 - 8597
Опубликована: Март 13, 2024
Adjuvant
treatment
after
surgical
resection
usually
plays
an
important
role
in
delaying
disease
recurrence.
Immunotherapy
displays
encouraging
results
increasing
patients'
chances
of
staying
cancer-free
surgery,
as
reported
by
recent
clinical
trials.
However,
the
outcomes
current
immunotherapy
need
to
be
improved
due
limited
responses,
patient
heterogeneity,
nontargeted
distribution,
and
immune-related
adverse
effects.
This
work
describes
a
programmable
hydrogel
adjuvant
for
personalized
resection.
By
filling
cavity,
this
system
aims
address
secretion
granzyme
B
(GrB)
during
improve
low
responses
typically
observed,
while
minimizing
side
The
TLR7/8
agonist
imidazoquinoline
(IMDQ)
is
linked
self-assembling
peptide
backbone
through
GrB-responsive
linkage.
Its
release
could
enhance
activation
function
immune
cells,
which
will
lead
increased
GrB
effectiveness
together.
recruits
initiates
dendritic
cell
maturation,
induces
M1
polarized
macrophages
reverse
immunosuppressive
tumor
microenvironment
situ.
In
multiple
murine
models,
suppresses
growth,
increases
animal
survival
long-term
immunological
memory,
protects
mice
against
rechallenge,
leading
effective
prophylactic
therapeutic
responses.
provides
potential
chemical
strategy
overcome
limitations
associated
with
immunotherapy.
