Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs DOI
Xiaoming Hu, Zhu-ting Fang,

Fengwei Sun

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(15)

Опубликована: Фев. 16, 2024

Abstract Developing Type‐I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type‐II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H 2 O reactive species (ROS). Herein, we propose electronic acceptor‐triggered photoinduced (a‐PET) strategy promoting separation electron‐hole pairs marriage two organic semiconducting a non‐fullerene scaffold‐based photosensitizer perylene diimide that significantly boost pathway produce plentiful ROS, especially, inducing 3.5‐fold 2.5‐fold amplification hydroxyl (OH⋅) superoxide (O − ⋅) generation. Systematic mechanism reveals intermolecular intramolecular charge after photoirradiation generate competent production radical ion promote process theoretical calculation ultrafast femtosecond transient absorption (fs‐TA) spectroscopy. By complementary diagnosis with photoacoustic imaging second near‐infrared fluorescence imaging, this as‐prepared nanoplatform exhibits fabulous photocytotoxicity in harsh hypoxic conditions terrific cancer revoked abilities living mice. We envision work will broaden insight into high‐efficiency phototheranostics.

Язык: Английский

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics DOI Creative Commons
Harshita Tiwari, Nilesh Rai, Swati Singh

и другие.

Bioengineering, Год журнала: 2023, Номер 10(7), С. 760 - 760

Опубликована: Июнь 25, 2023

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis treatment. Nanomaterials are extensively employed the field oncology because their minute size ultra-specificity. A wide range nanocarriers, such as dendrimers, micelles, PEGylated liposomes, polymeric nanoparticles used to facilitate efficient transport anti-cancer drugs at target tumor site. Real-time labeling monitoring cells quantum dots essential for determining level therapy needed The drug targeted site either by passive or active means. Passive targeting makes use microenvironment enhanced permeability retention effect, while involves ligand-coated nanoparticles. Nanotechnology being diagnose early stage detecting cancer-specific biomarkers imaging. implication employs photoinduced nanosensitizers, reverse multidrug resistance, enabling delivery CRISPR/Cas9 RNA molecules therapeutic applications. However, despite recent advancements nano-oncology, there need delve deeper into domain designing applying improved diagnostics.

Язык: Английский

Процитировано

69
Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia DOI
Bingli Lu, Lingyun Wang, Hao Tang

и другие.

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(21), С. 4600 - 4618

Опубликована: Янв. 1, 2023

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

Язык: Английский

Процитировано

56
Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy DOI Creative Commons
Yufu Tang, Yuanyuan Li, Bowen Li

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 21, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design precise side-chain engineering generate •O 2 − •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed skeletons can electron-hole pairs sensitize H O into with photoexcitation, achieving NIR-photoexcited oxygen-independent production. Further, compared commonly used alkyl side chains, glycol oligomer as the chain mitigates recombination offers more molecules around generated from hydrophobic skeletons, which yield 4-fold stronger production, thus allowing an high PDT effect. Finally, feasibility of developing activatable PSs in female mice further demonstrated irradiation 15 mW cm −2 . study not only provides insights mechanism also general guideline develop NIR PDT.

Язык: Английский

Процитировано

55
Photo‐Induced Disproportionation‐Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals DOI
Kun‐Xu Teng, Dongsheng Zhang,

Bin‐Kai Liu

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(12)

Опубликована: Янв. 23, 2024

We herein present an approach of photo-induced disproportionation for preparation Type-I photodynamic agents. As a proof concept, BODIPY-based photosensitizers were rationally designed and prepared. The intermolecular electron transfer between homotypic chromophores leads to the reaction, resulting in formation charged intermediates, cationic anionic radicals. radicals efficiently oxidize cellularimportant coenzyme, tetrahydrobiopterin (BH

Язык: Английский

Процитировано

40
Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

и другие.

Science China Chemistry, Год журнала: 2024, Номер 67(5), С. 1397 - 1441

Опубликована: Март 22, 2024

Язык: Английский

Процитировано

28
Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs DOI
Xiaoming Hu, Zhu-ting Fang,

Fengwei Sun

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(15)

Опубликована: Фев. 16, 2024

Developing Type-I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type-II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H

Язык: Английский

Процитировано

20
pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy DOI Creative Commons
Jianhua Zou, Zheng Li, Yang Zhu

и другие.

Bioactive Materials, Год журнала: 2024, Номер 34, С. 414 - 421

Опубликована: Янв. 10, 2024

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive tumor microenvironment (TME) enhance PDT through glutathione (GSH) depletion. Our approach aims expand sources therapeutic benefits by promoting generation superoxide radicals (O

Язык: Английский

Процитировано

19
Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer DOI
Yuqi Tang, Zhichao Wang, Quan Li

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(37)

Опубликована: Апрель 23, 2024

Abstract Breast cancer stem cells (CSCs) are responsible for the occurrence, resistance, recurrence, invasion, and metastasis of tumors. However, even trace amounts CSCs may lead to tumor resistance which fundamentally reduces therapeutic efficiency numerous anticancer drugs. Thus, development a agent that can reduce tumorigenicity overcome recurrence is essential. Here novel multifunctional prodrug T‐P reported as photosensitizer, links phenothiazine drug with synthesized aggregation‐induced emission photosensitizer T‐C via an ester bond. Importantly, this found be able induce pyroptosis breast well activate their death pathway protein phosphatase 2A inhibit systemic anti‐tumor effects. rapidly target mitochondria overlap lysosomes after mitochondrial escape, it cause lysosomal dysfunction. It releases reactive oxygen species through photoactivation, triggering pyroptosis‐mediated strong immune response. On 5th day in vivo therapy cancer, primary eliminated growth distant tumors also inhibited. This research would provide impetus new strategy CSCs‐targeted photoimmunotherapy beyond.

Язык: Английский

Процитировано

16
Photoinduced Cuproptosis with Tumor‐Specific for Metastasis‐Inhibited Cancer Therapy DOI

Jiazhu Zheng,

Haoying Ge,

Mengya Guo

и другие.

Small, Год журнала: 2023, Номер 20(10)

Опубликована: Окт. 25, 2023

Abstract Cuproptosis is a novel form of regulated cell death which guarantees to increase the efficacy existing anticancer treatments that employ traditional apoptotic therapeutics. However, reducing amount undesirable Cu ions released in normal tissue and maximizing Cu‐induced cuproptosis therapeutic effects at tumor sites are major challenges. In this study, exploiting chemical properties copper ionophores microenvironment, method developed for controlling valence cause photoinduced cells. CJS ‐Cu nanoparticles (NPs) can selectively induce after cascade reactions through H 2 O ‐triggered 2+ release, photoirradiation‐induced superoxide radical (∙O − ) generation, reduction + by ∙O . The generated reactive oxygen species result glutathione depletion iron–sulfur cluster protein damage further augmented cuproptosis. NPs effectively suppressed growth downregulated expression metastasis‐related proteins, contributing complete inhibition lung metastasis. Ultimately, study suggests avenues manipulation cellular photochemical reactions.

Язык: Английский

Процитировано

24
Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers DOI Creative Commons
Jiahao Zhuang, Guobin Qi,

Yecheng Feng

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 10, 2024

Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.

Язык: Английский

Процитировано

15